GABA Stimulates β-Cell Proliferation through the mTORC1/p70S6K Pathway, an Effect Amplified by Ly49, a Novel GABAA-R Positive Allosteric Modulator

Researchers demonstrated that GABA stimulates β‐cell proliferation via the PI3K/mTORC1/p70S6K pathway in both mouse and human islets.
[Diabetes Obesity & Metabolism]
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Multiplexing DNA Methylation Markers to Detect Circulating Cell-Free DNA Derived from Human Pancreatic Beta-Cells

Scientists describe an ultrasensitive assay for detection of a β-cell-specific DNA methylation signature, by simultaneous assessment of six DNA methylation markers, that identified β-cell DNA in mixtures containing as little as 0.03% β-cell DNA (less than one β-cell genome equivalent).
[JCI Insight]
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VentX Expression in Tumor Associated Macrophages Promotes Phagocytosis and Immunity against Pancreatic Cancers

Investigators found that the expression of homeobox protein VentX, a master regulator of macrophage plasticity, is significantly decreased in the ancreatic ductal adenocarcinoma (PDA)-tumor associated macrophages (TAMs). They demonstrated that VentX was required for phagocytosis and that restoration of VentX expression in PDA-TAMs promoted phagocytosis through regulating the signaling cascades involved in the process.
[JCI Insight]
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Insulin Receptor Endocytosis in the Pathophysiology of Insulin Resistance

The authors review the molecular mechanism of insulin receptor endocytosis and its impact on the pathophysiology of insulin resistance, and discuss the potential of Src homology phosphatase 2 as a therapeutic target for type 2 diabetes.
[Experimental and Molecular Medicine]
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Corbus Pharmaceuticals Reports Last Subject Visit in Phase IIb Study of Lenabasum for Treatment of Cystic Fibrosis

Corbus Pharmaceuticals Holdings, Inc. announced that the last subject completed their final visit in the company’s Phase IIb JBT101-CF-002 trial of lenabasum for the treatment of cystic fibrosis.
[Corbus Pharmaceuticals Holdings, Inc]
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Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]
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Virtual Lab Tours for Recruitment and Outreach

Virtual lab tours are not new, but they have never been as common as in-person lab tours. However, the pandemic has generated strong incentives for formerly in-person lab tours to go online.
[The Scientist]
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Identification of a Periodontal Pathogen and Bihormonal Cells in Pancreatic Islets of Humans and a Mouse Model of Periodontitis

Investigators determined the specific localization of Porphyromonas gingivalis in relation to mouse and human pancreatic α- and β-cells using 3-D confocal and immunofluorescence microscopy and orthogonal analyses.
[Scientific Reports]
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Altered RNA Splicing by Mutant p53 Activates Oncogenic RAS Signaling in Pancreatic Cancer

Scientists uncovered sequence-specific changes in RNA splicing enforced by mutant p53 which enhanced KRAS activity. Mutant p53 increased expression of splicing regulator hnRNPK to promote inclusion of cytosine-rich exons within GTPase-activating proteins, negative regulators of RAS family members.
[Cancer Cell]
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PharmaCyte Biotech Successfully Accelerates Development of Container Closure Integrity Test for Pancreatic Cancer Clinical Trial Product

PharmaCyte Biotech, Inc. announced that it has successfully accelerated the development of its Container Closure Integrity test– an essential component of the Stability Test required by the FDA.
[PharmaCyte Biotech Inc.]
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Beta-Cell Failure in Type 2 Diabetes: Mechanisms, Markers, and Clinical Implications

Researchers discuss the progression of type 2 diabetes mellitus in the context of beta-cell failure and describe how C-peptide testing can be used to assess beta-cell function in primary care practice.
[Postgraduate Medicine]
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