Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
Subscribe|Follow Us On
Integrated Signatures Define Mutational Processes in Prostate Cancer
[Nature] Scientists dissected the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group, identifying the etiologies and mutational processes that drive the genomic and clinical heterogeneity of prostate cancer.
Commensal Nakaseomyces Glabratus Migrates Into Prostate Tumors to Accelerate Cancer Progression
[Nature Cancer] Researchers found that oral administration of Nakaseomyces glabratus to castrated mice accelerated prostate cancer progression by promoting infiltration and activation of polymorphonuclear myeloid-derived suppressor cells.
Loss of NCOA6 Protein Causes Aggressive Prostate Cancer with EGFR Overexpression and Dependency
[Nature Communications] Investigators showed that genetic loss of NCOA6 accelerates tumor growth in human pancreatic cancer xenografts, induces prostate tumorigenesis in mice, and cooperates with Pten haploinsufficiency to drive aggressive metastatic pancreatic cancer.
Minimal-Length CAG Repeats in Define a Hyperactive AR-LSD1 Axis Driving Metabolic Reprogramming in Prostate Cancer
[Proceedings of the National Academy of Sciences of the United States of America] The authors established isogenic pancreatic cancer cell lines harboring the androgen receptor (AR) with a minimal length of CAG repeats and found that this AR variant exhibits attenuated response to AR-targeted therapies with markedly enhanced protein stability, expanded chromatin binding, and a reprogrammed transcriptional profile.
PGC1α-mediated Upregulation of PHD2 Represses HIF-Signaling, Limiting Prostate Cancer Progression
[Cell Death & Differentiation] Scientists showed that the PGC1α/ERRα complex reduces the protein levels of Hypoxia Inducible transcription Factor alpha in pancreatic cancer, providing a new component to the tumor-suppressive activity of the PGC1α/ERRα complex.
CRISPR/Cas9 Screening Revealed BIRC6-AS1/BIRC6 Mediates Abiraterone Resistance via NHEJ Pathway-Dependent A20 Degradation in Prostate Cancer
[Oncogene] Researchers identified BIRC6-AS1/BIRC6 as a significant contributor to abiraterone resistance in pancreatic cancer. They found depletion of either enhanced the sensitivity of pancreatic cancer cells to abiraterone in both in vitro and in vivo settings.
Proteomic Profiling Reveals That DPP4 Overexpression Increases Cell Adhesion, Inhibits Cell Migration, and Restores Androgen Sensitivity in Prostate Cancer
[Bioscience Reports] The authors investigated the expression and function of dipeptidyl peptidase-4 (DPP4) in androgen-sensitive and castration-resistant prostate cancer models.
Nutrient Deprivation Enhances the Cytotoxic Effects of a Sulfonamide-Chalcone Hybrid in PC-3 Prostate Cancer Cells
[Molecular and Cellular Biochemistry] Investigators reported the biological effects of a sulfonamide-chalcone hybrid in the PC-3 prostate cancer cell line under standard culture conditions and nutrient deprivation.
Metabolic Plasticity in Castration-Resistant Prostate Cancer: Reprogramming Mechanisms and Therapeutic Opportunities
[Cellular Signalling] Scientists comprehensively discuss the metabolic network, regulatory mechanism, and current challenges of castration-resistant prostate cancer.
Janux Therapeutics Announces First Patient Dosed in Phase 1 Study of JANX013
[Janux Therapeutics] Janux Therapeutics, Inc. announced that the first patient has been dosed in the Phase I clinical trial evaluating JANX013, a novel PSMA-targeted tumor-activated CD28 co-stimulatory bispecific, in patients with metastatic castration-resistant prostate cancer.
Neuromedin U ‘Innervation’ Reprograms Myeloid Immunosuppression in Neuroendocrine Prostate Cancer
[Oncogene] Using a transgenic mouse model, researchers showed that early stages of neuroendocrine prostate cancer are associated with increased intraprostatic recruitment of Ly6G+ polymorphonuclear neutrophils and reduced infiltration of CD8+ T cells.
UCLA Engineer Neil Lin Receives $2.1M DOD Grant to Develop AI “Digital Twins” Targeting Treatment-Resistant Prostate Cancer
[UCLA Samueli School of Engineering] The US Department of Defense has awarded a four-year, $2.1 million grant to a research team led by Dr. Neil Lin at the UCLA Samueli School of Engineering. The funding will support a new approach merging genetic testing, functional drug-sensitivity testing and advanced computer modeling into a single system for guiding prostate cancer therapy.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
