Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

In Vivo Self-Assembled Nano-PROTAC for the Dual Degradation of AR and HSP90 to Overcome Castration-Resistant Prostate Cancer Resistance

October 16, 2025

[Signal Transduction and Targeted Therapy] On the basis of in vivo self-assembly nanotechnology, investigators designed a PSMA-targeted nano-PROTAC with a proximity degradation effect.

Vir Biotechnology Announces First Patient Dosed in Part 3 of Phase I Trial of PSMA-Targeting PRO-XTEN® Dual-Masked T-Cell Engager VIR-5500 in Combination with Androgen...

October 10, 2025

[Vir Biotechnology, Inc.] Vir Biotechnology, Inc. announced that the first patient has been dosed in Part 3 of the Company’s Phase I clinical trial evaluating VIR-5500 in combination with androgen receptor pathway inhibitors.

New Alliance Trial Aims to Improve Outcomes in Metastatic Prostate Cancer

October 10, 2025

[The Alliance for Clinical Trials in Oncology (EurekAlert)] The Alliance for Clinical Trials in Oncology has launched the ASPIRE trial, a large-scale, Phase III clinical study investigating whether adding chemotherapy to current standard treatments can extend survival for men living with advanced prostate cancer.

Elucidating Molecularly Stratified Single Agent, and Combination, Therapeutic Strategies Targeting MCL1 for Lethal Prostate Cancer

October 8, 2025

[Nature Communications] Researchers characterize MCL1 in multiple metastatic CRPC biopsy cohorts and patient-derived models, assessing responses to MCL1 inhibition.

Recurrent Immunogenic Neoantigens and Their Cognate T Cell Receptors in Treatment-Resistant Metastatic Prostate Cancer

October 8, 2025

[Cancer Discovery] Scientists demonstrated that androgen receptor (AR) H875Y specific T cell receptors are highly specific and kill prostate cancer cells presenting AR neo-peptides in vitro and in vivo.

Combined SNPs Sequencing and Allele Specific Proteomics Capture Reveal Functional Causality Underpinning the 2p25 Prostate Cancer Susceptibility Locus

October 8, 2025

[Nature Communications] Clinical findings reveal a synergistic effect between rs4519489 genotype and NOL10 expression on prostate cancer prognosis and severity.

Niraparib and Abiraterone Acetate Plus Prednisone for HRR-Deficient Metastatic Castration-Sensitive Prostate Cancer: A Randomized Phase 3 Trial

October 7, 2025

[Nature Medicine] Investigators hypothesized that PARP inhibition within 6 months of starting androgen deprivation therapy for metastatic castration-sensitive prostate cancer could be effective and improve radiographic progression-free survival when added to standard-of-care treatments.

Overexpression of RUNX2 Promotes Breast Cancer Multi-Organ Metastasis through Stabilizing C-Myc

October 6, 2025

[Cell Death & Disease] Researchers found here that overexpression of RUNX2 drives synchronous multi-organ metastases rather than bone-preferred metastasis in multiple mouse models of breast cancer, regardless of subtype.

Targeting the Redox-Programmed Cell Death Axis in Breast Cancer: From Molecular Mechanisms to Therapeutic Resistance

October 6, 2025

[Cell Death & Disease] The authors summarize the dynamic balance between ROS production and clearance, as well as the characteristics of various forms of cell death induced by ROS, including pyroptosis, apoptosis, necroptosis, autophagy, ferroptosis, cuproptosis, disulfidoptosis, oxeiptosis, and epigenetic regulation of these types of cell death.

HSF1-DBC1 Axis Drives Prostate Cancer Progression by Activating a Metastatic Transcriptional Program

October 6, 2025

[Experimental & Molecular Medicine] Investigators show that heat shock factor 1 (HSF1) is highly activated and required for metastatic spread and growth of metastatic CRPC cells.

Targeting Histone H2B Acetylated Enhanceosomes via P300/CBP Degradation in Prostate Cancer

October 6, 2025

[Nature Genetics] Researchers identified p300/CBP-mediated multisite histone H2B N-terminal acetylation as a defining feature of oncogenic enhanceosomes in androgen receptor-positive prostate cancer.

A Review of Exercise-Induced Epigenetic Modifications in Prostate Tissue: Implications for Gene Expression and Tumor Progression in Prostate Cancer

October 6, 2025

[Cancer Cell International] There is growing evidence that physical exercise is associated with epigenetic alterations in prostate tissue, although its consequences on the prostate are yet unknown. Scientists summarize research on the molecular processes and therapeutic applications of exercise in prostate tissue, particularly in the context of prostate cancer.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.