Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
Subscribe|Follow Us On
Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer
[Advanced Science] Researchers integrated multi-omics analyses of resistant models and patient specimens, identifying glutathione S-transferase alpha 4 (GSTA4) as a pivotal ferroptosis suppressor that drives antiandrogen resistance in castration-resistant prostate cancer.
EZH2-dependent phenotypic plasticity reveals TTP-associated and mTORC1 therapeutic vulnerabilities in lethal prostate cancer
[Cell Reports Medicine] Scientists identified enhancer of zeste homolog 2 (EZH2)-PI3K/mTORC1 signaling as a therapeutic vulnerability in phenotypically plastic prostate cancer and revealed tristetraprolin (TTP)-associated regulatory programs as contributors to targeted therapy response.
Follistatin Drives AR-Independent Prostate Cancer through BMP Signaling Inactivation and Microenvironmental Remodeling
[Proceedings of the National Academy of Sciences of the United States of America] The authors identified follistatin, a TGFβ superfamily antagonist, as a key driver of androgen receptor (AR)-independence and treatment resistance in prostate cancer.
PYGO2 Ablation Promotes Lymphoid Organization and STING-Dependent Antitumor Immunity in Prostate Cancer
[Cancer Letters] Researchers investigated whether the frequently amplified chromatin effector PYGO2 regulates lymphoid organization and antitumor immunity in prostate cancer.
Multiomics Comparison between Prostate Cell Lines and Patient-Derived Tissue to Evaluate Cell Line Clinical Relevance
[Communications Medicine] Investigators assessed the clinical relevance and inclusivity of 46 prostate cancer cell lines using an integrated clinical and multiomics approach.
Senescence-Associated Prostate Cancer Cells Promote Fibroblast Reprogramming and Extracellular Matrix Remodeling
[Neoplasia] Scientists integrated human prostate cancer specimens, public single-cell RNA-sequencing datasets, a prostate-specific Pten conditional knockout (Pten-cKO) mouse model, mouse single-cell transcriptomic analysis, and mechanistic in vitro experiments to investigate senescence and stromal remodeling.
Physiological Elasticity and Topography Modulate In Vitro Prostate Cancer Cell Behavior
[iScience] The authors investigated how physiologically relevant mechanical properties affect prostate cancer cells using 2D-poly(dimethylsiloxane) and topographic 2.5D-poly(ethylene glycol) diacrylate-glycidyl methacrylate hydrogel surfaces.
TRPM4 Expression As a Predictive Biomarker and a Mechanistic Driver of Acetalax Activity in Prostate Cancer: Preclinical Efficacy Studies
[Molecular Cancer Therapeutics] Researchers investigated whether transient receptor potential melastatin 4 (TRPM4) expression defines Acetalax sensitivity in prostate cancer, comparing TRPM4-high and -low prostate cancer cell lines.
Integrated Reverse Network Toxicology and Experimental Validation Identify PTP4A3 As a Key Target of Benzo[a]Pyrene in Prostate Cancer
[Chemico-Biological Interactions] The authors suggested that benzo[a]pyrene could contribute to the acquisition of pro-invasive phenotypes in prostate epithelial cells and potentially to prostate carcinogenesis, probably through upregulating PTP4A3 to activate matrix remodeling programs.
Metabolomic Profiling and Anticancer Effects of Red Sea Sponges Liosina Granularis and Callyspongia Crassa on Prostate and Ovarian Cancer Cells
[Scientific Reports] Researchers investigated the metabolomic profiles and preliminary anticancer activity of methanolic extracts from two Red Sea sponge species, Liosina granularis and Callyspongia crassa, using prostate and ovarian cancer cell models.
Aurora Kinase a Phosphorylates and Stabilizes UHRF1 to Maintain DNA Methylation and Prostate Cancer Cell Survival
[Epigenetics] Investigators identified AURKA, a serine/threonine kinase, as a key regulator of global DNA methylation in prostate cancer cells. AURKA depletion markedly reduces genomic 5-methylcytosine levels.
Matrine Induces Aggressive Prostate Cancer Cell Death via Inhibition of PPARα Activity: Insights from Transcriptomics, Molecular Docking, and Functional Studies
[Experimental Cell Research] Scientists assessed the anti-proliferative effects of matrine in multiple prostate cancer cell lines (LNCaP, C4-2, PC3, Du145) using CCK-8, EdU, and colony formation assays.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
