Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Disrupting the Interaction between Androgen Receptor and Its Coregulator WDR77 Delays the Growth of Treatment-Resistant Prostate Cancer

September 12, 2025

[Cell Reports] Researchers demonstrated the therapeutic potential of disrupting interactions between the androgen receptor and its coregulator WDR77. WDR77 stimulates prostate cancer growth, and its overexpression was associated with worse patient survival.

miRNA-Mediated Resistance Mechanisms in Prostate Cancer: Implications for Targeted Therapy and Metastatic Progression

September 12, 2025

[Medical Oncology] The authors present a novel, mechanism-centered synthesis focused specifically on miRNA-mediated resistance pathways across standard treatment modalities, including androgen deprivation therapy, enzalutamide, docetaxel, and radiotherapy.

Enzalutamide-Resistant STEAP4+ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone-Sensitive Prostate Cancer

September 11, 2025

[Advanced Science] Through comprehensive single-cell transcriptomic profiling of enzalutamide (ENZ)-naïve and ENZ-treated tumors, an expansion of ENZ-resistant myofibroblastic cancer-associated fibroblast was identified that correlates with adverse clinical outcomes.

Extracellular Domain Shedding of TROP2 Activates EGFR Signaling to Drive Prostate Cancer Metastasis

September 11, 2025

[Cancer Research] While shed TROP2 extracellular domain did not affect prostate cancer cell proliferation and tumor growth, it increased cell migration and invasion in vitro and promoted metastatic colonization and spontaneous metastasis in vivo.

EDAP Receives HIFU Reimbursement for Prostate Cancer in France

September 9, 2025

[EDAP TMS (BioSpace)] EDAP TMS announced that the French Ministry of Health has awarded reimbursement for High Intensity Focused Ultrasound (HIFU) procedure for the treatment of prostate cancer in France.

Localized High-Risk Prostate Cancer Harbors an Androgen Receptor Activity-Low Subpopulation Susceptible to HER2 Inhibition

September 9, 2025

[Journal of Clinical Investigation] Baseline HER2 activity marks intrinsic resistance to neoadjuvant androgen deprivation therapy in localized high-risk prostate cancer and identifies a preexisting, targetable androgen receptor-low subpopulation.

Targeting TRPV6/CXCR4 Complexes Prevents Castration-Resistant Prostate Cancer Metastasis to the Bone

September 8, 2025

[Signal Transduction and Targeted Therapy] Using a cohort of prostate cancer tissue biopsies from patients with a clinical history of at least 10 years after biopsy, scientists reported that TRPV6 expression directly correlates with CRPC tumor aggressiveness and increased risk of metastasis development.

ECD, a Novel Androgen Receptor Target Promotes Prostate Cancer Tumorigenesis by Regulating Glycolysis

September 5, 2025

[Oncogene] In the TCGA database, scientists observed a positive correlation between ECD and androgen receptor (AR) expression. Consistently, dihydrotestosterone treatment of prostate cancer cell lines increased ECD mRNA and protein levels, and AR knockdown reduced ECD expression.

Divergent FOXA1 Mutations Drive Prostate Tumorigenesis and Therapy-Resistant Cellular Plasticity

September 5, 2025

[Science] Investigators developed and characterized genetically engineered mice with targeted knock-in of human cancer-associated FOXA1 Class 1 and Class 2 mutant transgenes.

LHX2 Rewires the Metabolic and Epigenetic Landscape to Drive Tumor Progression in Prostate Cancer

September 5, 2025

[Cancer Research] The authors elucidated a reciprocal metabolic-epigenetic mechanism involving a positive feedback loop between glycolysis and the transcription factor LHX2 that promotes prostate cancer progression.

Damon Runyon Cancer Research Foundation Awards $4.8 Million to Exceptional Early-Career Scientists

August 29, 2025

[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows. This fellowship encourages young scientists to pursue careers in cancer research by providing them with independent funding to investigate cancer causes, mechanisms, therapies, and prevention.

Tumor Transcriptome-Wide Expression Classifiers Predict Treatment Sensitivity in Advanced Prostate Cancers

August 29, 2025

[Cell] To identify novel biomarker-treatment pairings, researchers examined associations between biological pathways and 14-year survival outcomes of patients randomized in practice-changing Phase III trials. They included transcriptome-wide expression signatures and immunohistochemistry markers on prostate tumors from 1,523 patients.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.