Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

Gasdermin D Antagonizes Immunosuppression in Prostate Cancer by Inducing LAMC2 Degradation to Block M2 Macrophage Polarization

May 28, 2026

[Journal for Immunotherapy of Cancer] Researchers investigated the potential non-pyroptotic mechanism of action of gasdermin D (GSDMD) in preventing prostate cancer (PCa) immune evasion. They revealed a novel non-pyroptotic pathway through which GSDMD inhibits PCa immune evasion by targeting laminin subunit gamma-2 (LAMC2) for degradation.

Single-Cell and Spatial RNA Sequencing in Prostate Cancer

May 28, 2026

[Nature Reviews Urology] Spatial transcriptomics enables the characterization of tumor architecture using spatial resolution at the single-cell or multi-cell level. These approaches also permit bioinformatic inference of large-scale copy number variants, enabling integrated genomic–transcriptomic analysis of clonal evolution and therapy resistance.

2026 Publishing Award Recipient Advances Clarity in Prostate Cancer Screening

May 28, 2026

[AAPA] Dr. Michael Gerlach has built his career at the intersection of clinical care, leadership, and evidence‑based medicine, guided by a longstanding commitment to improving outcomes for patients navigating difficult health decisions. He is the recipient of the 2026 AAPA Publishing Award.

Bobba Receives Young Investigator Award for Prostate Cancer Research

May 28, 2026

[University of Tennessee] Dr. Kondapa Naidu Bobba has been selected to receive the 2026 Young Investigator Award, which is jointly supported by the Prostate Cancer Foundation and Society of Nuclear Medicine and Molecular Imaging to advance important prostate cancer research among early-career physicians and scientists.

FARP1 Mediates cMET-Driven Motility in Androgen-Independent Prostate Cancer Cells

May 28, 2026

[Endocrinology] Scientists shed light on the distinctive contribution of Rac guanine nucleotide exchange factors to prostate cancer cell motility via receptor tyrosine kinases and identifed FARP1 as a crucial cMET-invasive effector.

VprBP Drives Prostate Tumorigenesis by Its Kinase Activity Targeting Histone H2A

May 28, 2026

[Cell Communication and Signaling] Researchers reported that VprBP is highly expressed in prostate cancer cells and inactivates a group of genes encoding critical regulators of cell growth and proliferation in a manner dependent on its kinase activity toward H2AT120.

A Forward Genetic Screen Identifies Sirtuin1 As a Driver of Neuroendocrine Prostate Cancer

May 28, 2026

[Journal of Experimental Medicine] Gain- and loss-of-function studies in human prostate cancer cells and mouse neuroendocrine prostate cancer (NEPC) organoids confirmed that sirtuin 1 promotes NEPC, while pharmacological inhibition suppresses it.

Decoding the Raf-Mek-Erk-Rsk Pathway in Prostate Cancer: From Molecular Mechanisms to Clinical Opportunities

May 15, 2026

[British Journal of Cancer] Whilst inhibitors of the RAF-MEK-ERK-RSK pathway have demonstrated clinical utility in other cancers this has not been realized in prostate cancer. The reasons for this include a lack of predictive biomarkers for, and the unique landscape of pathway activation.

HOXD11-NMDAR Signaling Drives Neuroendocrine Prostate Cancer and Enables Potential Therapeutic Intervention As a Target of Memantine

May 15, 2026

[Cell Reports] Using single-cell RNA sequencing of transgenic adenocarcinoma of the mouse prostate mice across pathological stages, scientists found an early neuroendocrine-initiating cluster marked by elevated HOXD11, conserved in human neuroendocrine prostate cancer.

LGALS9 Blockade Augments Vaccine-Induced Immune Responses against Prostate Cancer

May 15, 2026

[Journal for Immunotherapy of Cancer] Scientists generated recombinant adenoviral vaccines encoding PSMA and LGALS9 (Ad-PSMA and Ad-LGALS9) for antigen expression in vitro and in vivo. They evaluated therapeutic efficacy in murine subcutaneous, bone metastatic, and humanized prostate cancer models.

The RPS15-DDX21 Complex Drives Prostate Malignancy through Transcriptional Activation of SCD1

May 15, 2026

[Oncogene] Researchers demonstrated that RPS15 significantly promotes proliferation and migration in prostate cancer through the establishment of ribosomal protein S15 (RPS15) knockdown cells and xenograft models.

The Microbiome across the Prostate Disease Continuum: From Health and BPH to Prostatitis/CPPS and Cancer

May 15, 2026

[Oncogene] By integrating mechanistic, spatial and clinical evidence, the authors propose a stage-aware framework for the gut–urinary–prostatic axis and delineate when microbial and metabolite signalling meaningfully conditions prostate disease biology—and when it does not.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.