Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

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Four Million Euros in EU Funding to Improve Prostate Cancer Care

[German Cancer Research Center] The European Commission is funding the “PROMETHEUS” consortium project with a total of four million euros over four years, of which 1.6 million euros will be allocated to the German Cancer Research Center.

Vir Biotechnology Announces PSMA-targeted PRO-XTEN® Dual-masked T-cell Engager VIR-5500 Received FDA Fast Track Designation for the Treatment of Prostate Cancer

[Vir Biotechnology, Inc.] Vir Biotechnology, Inc. announced that the US FDA granted Fast Track designation to VIR-5500, a PSMA-targeted PRO-XTEN® dual-masked T-cell engager, for the treatment of late-line metastatic CRPC.

Prostate Cancer Foundation Honors Mary-Ellen Taplin, MD, with the 2026 PCF Women in Science Lifetime Achievement Award

[Prostate Cancer Foundation] The Prostate Cancer Foundation announced Mary-Ellen Taplin, MD, as the recipient of the 2026 PCF Women in Science Lifetime Achievement Award.

Two Foundation Grants Advance Prostate Cancer Research at Desai Sethi Urology Institute

[University of Miami Miller School of Medicine] Two foundation grants will support University of Miami Miller School of Medicine researchers, Zhipeng Wang, Ph.D., and Masoud Bitaraf, M.D., studying how prostate cancer progresses and becomes resistant to treatment.

tRNA Dosage Regulates Lineage Dependency and Resistance in Prostate Cancer

[Nature] Using prostate cancer as a model of lineage dependence, scientists performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineage transitions and therapy resistance.

The Molecular Heterogeneity and Clinical Impact of Genomic Driver Alterations in Prostate Cancer

[Nature Communications] The authors performed an integrative analysis of cancer driver genes by quantifying recurrent genomic alterations among small mutations, structural variants, and copy number alterations in 961 primary prostate tumour samples.

Mechanism-Informed Language Modeling and Oxygenated 3D Screening Identify Berberine-Enzalutamide Synergy in Prostate Cancer Models

[Advanced Science] Investigators introduced a hybrid in silico and in vitro lead discovery platform that integrates knowledge-augmented large language models with an oxygen-supplemented 3D spheroid system.

Citron Kinase Activity Controls Alternative Splicing Events That Drive Prostate Cancer Growth

[Science Advances] Researchers showed that citron kinase-mediated alternative splicing drives prostate cancer progression, and its inhibition is a new therapeutic strategy in treatment-resistant prostate cancer.

Prostate Cancer Patient-Derived Organoids (PDOs) As Functional Avatars for Antisense Oligonucleotide (ASO)-Based Personalized Therapy

[Advanced Healthcare Materials] The authors adapted previously described protocols to establish a biobank of prostate cancer patient-derived tumor organoids, achieving a high initial growth success rate (>90%).

LGR4 Interacts with RhoA to Modulate Cell Survival and Epithelial-Mesenchymal Transition via the Wnt/β-Catenin Pathway in Benign Prostatic Hyperplasia

[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Scientists investigated the roles of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) in benign prostatic hyperplasia using human prostate tissues and cultured human prostate cells.

Preclinical Characterization of ADCT-241, an Exatecan-Based Antibody-Drug Conjugate against PSMA for the Treatment of Metastatic Castration-Resistant Prostate Cancer

[Molecular Cancer Therapeutics] Investigators demonstrated potent, specific in vitro and in vivo antitumor activity of ADCT-241, a novel antibody–drug conjugate, warranting progression of ADCT-241 into clinical trials in patients with metastatic CRPC.

Cribriform and Intraductal Carcinoma in Prostate Cancer – Implications for Risk Stratification and Therapeutic Decision-Making

[Nature Reviews Urology] The authors discuss intraductal carcinoma of the prostate and invasive cribriform carcinoma, closely related high-risk morphologies that frequently coexist and are associated with adverse pathology, early metastasis, and disease-specific mortality across the prostate cancer continuum.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

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