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Prostate Cell News
Prostate Cell News is an online resource summarizing the latest prostate cell research.
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Reprogramming the GRHL2−CDK19 Axis by Gene Therapy Alleviates Prostate Aging
[Nature Aging] Scientists integrated single-nucleus transcriptomics and histological analyses to elucidate the aging mechanisms of the primate prostate.
Targeting CHD1L Suppresses Prostate Cancer Progression via the FOXO3-PUMA Axis
[Journal of Translational Medicine] The authors investigated the biological significance of chromodomain helicase DNA binding protein 1-like (CHD1L) in prostate cancer and to evaluate the therapeutic potential of its selective inhibitor OTI-611.
Megalin (LRP2) Expression Patterns in Prostate Cancer Stem Cells and Metastatic Subtypes: Implications for Tumor Progression and Metabolism
[The Prostate] LRP2 showed subtype-specific expression patterns in prostate cancer, with elevated levels in DU-145 cancer stem cells and metastatic tumors.
Decoding GDF15: Impact on Prostate Cancer Metabolism, Chemoresistance, and Clinical Applications
[Chinese Medical Journal] The authors analyze the complex role of growth differentiation factor 15 (GDF15) in various aspects of prostate cancer, including metabolism, chemoresistance, metastasis, and clinical implications.
GeneLife Expands GeneAI Forecast with New Cancer Risk Prediction Models
[A.D.A.M. Innovations, Co. ] A.D.A.M. Innovations, Co. announced the release of three new first-of-their-kind cancer prediction models for its GeneLife GeneAI Forecast platform: breast cancer, prostate cancer, and pancreatic cancer, developed using the largest Japanese population genetic database, improving relevance compared with Western-derived tools.
NSD2 Targeting Reverses Plasticity and Drug Resistance in Prostate Cancer
[Nature] The authors showed that plasticity-associated treatment resistance in CRPC can be reversed through the inhibition of NSD2, a histone methyltransferase.
ACTC1 Promotes Tumor Progression by Upregulating BMP4 Expression in Prostate Cancer
[BMC Cancer] Integrative analysis of public datasets and immunohistochemistry revealed that ACTC1 is upregulated in prostate cancer.
Targeting FZD6 Creates Therapeutically Actionable Vulnerabilities for Advanced Prostate Cancer
[Oncogene] Scientists showed that frizzled (FZD) 6 is the most highly expressed and frequently amplified Wnt receptor in advanced human prostate cancers.
Effect of TGF-β Mediated Phenotypic Changes on Prostate Cancer Cell Anoikis Response
[Oncogene] Scientists investigated how TGF-β regulated mesenchymal epithelial transition phenotypic interconversions to enhance anoikis response in pre-clinical models of prostate cancer.
Spatial Multi-Omics Identifies Aggressive Prostate Cancer Signatures Highlighting Pro-Inflammatory Chemokine Activity in the Tumor Microenvironment
[Nature Communications] Investigators interrogated spatially resolved multi-omics data to find molecular stratifiers of aggressive prostate cancer.
EZH2 Suppression Diversifies Prostate Cancer Lineage Variant Evolution and Lacks Efficacy in Inhibiting Disease Progression
[Cancer Research] As inhibitors of the histone methyltransferase EZH2 are being evaluated clinically for the treatment of advanced prostate cancer (PrCa), researchers investigated here how EZH2 affects PrCa lineage plasticity.
MYC and P53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T-Cell and Immunotherapy Responses in Prostate Cancer
[Cancer Research] Using innovative electroporation-based mouse models, scientists generated distinct genetic subtypes of CRPC found in patients and uncovered unique immune microenvironments.
Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.
