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[University of Missouri] In a major leap for cancer care at the University of Missouri, the School of Medicine and MU Health Care have launched their first clinical trial using a leading-edge therapy manufactured on campus at the university’s research reactor.

[Nature] Scientists demonstrated the function of ATF6α as an endoplasmic reticulum (ER)-stress-inducing tumor driver and metabolic master regulator restricting cancer immunosurveillance for hepatocellular carcinoma, in contrast to its well-characterized role as an adaptive response to ER stress.

[Cell Death & Disease] Researchers investigated how hepatocyte ploidy affects susceptibility to acetaminophen-induced liver injury by comparing diploid-enriched liver-specific knockout of E2f7/E2f8 and polyploid-enriched control mice.

[Journal of Translational Medicine] Investigators found that EP300 is consistently upregulated in hepatocellular carcinoma and supports malignant phenotypes in vitro and in vivo.

[Journal of Medicinal Chemistry] The authors confirmed that pre-let-7-PROTACs reduce tumor stemness by degrading Lin28B, offering a promising therapeutic approach for hepatocellular carcinoma.

[Communications Biology] Researchers showed that transforming growth factor-beta-induced protein (TGFBI) promotes liver fibrosis in male C57BL/6 mice. TGFBI was upregulated in fibrotic livers and derived from non-parenchymal cells.

[Journal of Physiology and Biochemistry] Scientists uncovered how fibrosis and diabetes interact to modulate enterohepatic communication, providing insights into metabolic-associated steatotic liver disease pathophysiology and identifying potential therapeutic targets for disease management.

[International Immunology] Investigators aimed to establish a robust methodology to analyse primary hepatic stellate cells in human liver specimens with flow cytometry.

[Chinese Medical Journal] Scientists provide an overview of liver organoid development and discusses their applications in liver regeneration, disease modeling, drug screening, toxicity assessment, organ transplantation, and regenerative medicine.

[Cell] The authors deciphered that sensory neurons, the dominant neuron type in the triple negative breast cancer ecosystem, drive the immune-excluded tumor microenvironment by stimulating a dense extracellular matrix.

[Advanced Materials] Scientists hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts.

[Nature Communications] Researchers showed that the ECM component hyaluronan mediates adherens junction-independent circulating tumor cell clustering in triple-negative breast cancers.