Keep Current with the Latest in Cell Biology Research

B Cell Expansion Hinders the Stroma-Epithelium Regenerative Cross Talk during Mucosal Healing

[Immunity] To gain insight into the process of mucosal healing, researchers longitudinally examined the immune cell composition during intestinal damage and regeneration.

Epithelial TGFβ Engages Growth-Factor Signaling to Circumvent Apoptosis and Drive Intestinal Tumourigenesis with Aggressive Features

[Nature Communications] Investigators identified a cohort of born to be bad early-stage colorectal tumours, with aggressive features and a propensity to disseminate early, that were characterized by high epithelial cell-intrinsic TGFβ signaling.

HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell Fate

[Cellular and Molecular Gastroenterology and Hepatology] Researchers used transcriptomic analyses to dissect the role of HNF4α in the maintenance of jejunal epithelial culture when cultured ex vivo as enteroids, in the presence or absence of compensatory mesenchymal cells.

Bacterial Protein MakA Causes Suppression of Tumour Cell Proliferation via Inhibition of PIP5K1α/Akt Signaling

[Cell Death & Disease] The authors evaluated the effects of MakA on the host cell PIP5K1α lipid-signaling pathway and the mechanism by which MakA inhibited cell proliferation and induced cell cycle arrest, particularly in HCT8 colon cancer cells.

Artesunate Delays the Dysfunction of Age-Related Intestinal Epithelial Barrier by Mitigating Endoplasmic Reticulum Stress/Unfolded Protein Response

[Mechanisms of Ageing and Development] Investigators demonstrated that the intestinal KIT signaling declined and deactivated with aging, parallel with epithelial barrier dysfunction.

The EDN1/EDNRA/β-Arrestin Axis Promotes Colorectal Cancer Progression by Regulating STAT3 Phosphorylation

[International Journal of Oncology] Scientists investigated biological functions and novel downstream signaling pathways affected by endothelin receptor A, during colorectal progression.

Comprehensive microRNA Analysis across Genome-Edited Colorectal Cancer Organoid Models Reveals miR-24 as a Candidate Regulator of Cell Survival

[BMC Genomics] Using genetically-modified mouse intestinal organoid (enteroid) models, researchers identified 12 different modules of microRNA expression patterns across different combinations of mutations common in colorectal cancer.

Inhibition of Wnt7b Reduces the Proliferation, Invasion, and Migration of Colorectal Cancer Cells

[Molecular Biology Reports] Researchers explored the effects of Wnt7b regulating the Wnt/β-catenin signaling pathway on the proliferation, migration, and invasion of SW480 cells in colorectal cancer.

The Potential Mechanism of Neu5Gc Inducing Colorectal Cancer Based on Network Pharmacology and Experimental Validation

[Naunyn-Schmiedebergs Archives of Pharmacology] Scientists found that Neu5Gc promoted the proliferation of colorectal cancer cells and normal intestinal epithelial cells, and further screened out 98 Neu5Gc targets related to the occurrence and development of colorectal cancer by network pharmacology.

Biomerica Receives KFDA and Ministry of Health Approval for Colorectal Screening and Breast Screening Tests in Saudi Arabia and UAE

[Biomerica, Inc.] Biomerica, Inc. received clearance from the Kingdom of Saudi Arabia Food and Drug Administration (KFDA), and the United Arab Emirates (UAE) Ministry of Health and Prevention for the EZ Detect Colon Disease test and the Aware® Breast Self Exam device.

Are Chemical Compounds in Medical Mushrooms Potent against Colorectal Cancer Carcinogenesis and Antimicrobial Growth?

[Cancer Cell International] The authors substantiate the potency of medical mushrooms and its secondary metabolites concerning colon cancer carcinogenesis and antimicrobial growth.

Inactivation of LATS1/2 Drives Luminal-Basal Plasticity to Initiate Basal-Like Mammary Carcinomas

[Nature Communications] Using genetic mouse models and ex vivo primary organoid cultures, scientists showed that conditional co-deletion of the LATS1 and LATS2 kinases in mature mammary luminal epithelial cells promoted the development of Krt14 and Sox9-expressing basal-like carcinomas that metastasize over time.

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