[Molecular Genetics and Genomics] Scientists revealed that melatonin can reduce melanocyte viability, inhibit proliferation, promote apoptosis, reduce melanogenesis, and affect melanin synthesis through the Wnt/β-catenin signaling pathway.

[Cell Death & Disease] The authors demonstrated that receptor-interacting protein kinase 3 (RIPK3) expression was significantly upregulated in psoriasis patients and mice with imiquimod-induced skin inflammation

[Proceedings of the National Academy of Sciences of the United States of America] Scientists investigated the role of collectin-11, an epithelial-secreted carbohydrate-binding lectin that drives innate immunity and eliminates pathogens by complement activation.

[Science Immunology] Researchers showed using a mouse model of chronic allergic airway inflammation that long-chain unsaturated fatty acids accumulate in the inflammatory milieu during chronic airway inflammation.

[Science Immunology] The authors demonstrated that mitochondrial and lysosomal signaling orchestrates Treg cell metabolic and functional fitness.

[Journal of Hematology & Oncology] The authors summarize the progress of universal allogeneic CAR-T cell therapies, addresses the critical challenges, and discusses the future directions for their clinical implementation.

[Nature Aging] Using single-cell sequencing, scientists analyzed 387,762 cells from human thymus and peripheral blood of young and aged individuals. Aged thymus were enriched in mature T cells with low SOX4 expression and inflammatory profiles but depleted of thymic epithelial cells and expression of tissue-restricted antigens.

[Nature Communications] Scientists show that EWS::FLI1 expression in human embryonic MSCs results in the acquisition of an Ewing sarcoma transcriptome, with the oncogene not preferentially binding to gene promoters, but to intronic and intergenic microsatellites.

[Nature Reviews Immunology] Scientists place independent findings from several groups into a working model of immune cells as the architects of tissue barriers, to present a framework on which new concepts and findings in this area can develop.

[Nature Communications] Researchers investigated molecular mechanisms underlying post-COVID syndrome (PCS) using single-cell RNA (scRNA) transcriptomics combined with in vitro validation. scRNA analysis was performed on nasal biopsies from 25 patients with moderate or severe PCS to investigate differential cell types, signaling pathways, and cell-cell communication.

[Clinical Reviews in Allergy & Immunology] The authors summarize the fundamental principles of T cell metabolic reprogramming, its causative role in propelling T cell senescence, and the dynamic interplay between metabolic dysfunction, T cell senescence, and disease pathogenesis.

[Journal of Leukocyte Biology] To gain insights into rhesus theta defensin regulation of naïve cells, researchers performed RNA sequencing to determine the effect of the peptide on global gene expression in human monocytes and THP-1 monocytes.