[Virginia Commonwealth University] Shunlin Ren, M.D., Ph.D., was notified of the election to the 2025 class of fellows of the National Academy of Inventors, the highest professional distinction for academic inventors in the United States.

[Journal of Medicinal Chemistry] The authors introduced XAN-5, a novel mitochondrial DNA G-quadruplex-targeting tetrahydroxanthylium ligand that can simultaneously induce apoptosis and inhibit autophagy.

[Biomaterials Science] Scientists explored the therapeutic potential of regenerated silk fibroin scaffolds loaded with dual growth factors for reversing hepatic fibrosis.

[Food & Function] Scientists demonstrated that chlorogenic acid, a natural antioxidant, markedly alleviates chronic restraint stress-induced liver injury in rats.

[Scientific Reports] Investigators tried to elucidate the role of UPR pathway in exacerbating HCC prognosis under the condition of alcohol-associated HCC.

[European Journal of Medical Research] Investigators explored VPS72 mRNA and protein levels in HCC using bioinformatics and clinical samples, examining their relationship with clinical factors and immune cell infiltration.

[Biochemical and Biophysical Research Communications] Researchers systematically investigated the collaborative roles of lysyl oxidase like 2 (LOXL2) and synoviolin 1 (SYVN1) in liver hepatocellular carcinoma progression and their underlying molecular mechanisms.

[Nature Reviews Gastroenterology & Hepatology] Scientists discuss the strengths and weaknesses of prevalent metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis-hepatocellular carcinoma preclinical models, expanding the discussion to the latest advances in vivo and in vitro.

[Biogen, Inc. ] Biogen Inc. announced that the US FDA has granted Breakthrough Therapy Designation for litifilimab for the treatment of cutaneous lupus erythematosus (CLE). Litifilimab is a first in-class, humanized IgG1 monoclonal antibody targeting blood dendritic cell antigen 2.

[NPJ Vaccines] Scientist developed a novel class of tolerogenic vaccines based on recombinant virus-like particles, engineered to display the immune checkpoint molecule CTLA-4 on their surface and incorporate specific antigens.

[Nature Communications] The authors showed that the JAK3/STAT5 signaling pathway is critical for maintaining TH2 lineage stability by modulating Blimp1 and c-Maf thereby suppressing TH17 differentiation.

[Journal of Experimental Medicine] Investigators showed that DOCK8 promotes STAT3 activity, which inhibits GATA3 in T cells.