[Nature Cell Biology] Scientists found that bridge-like lipid transport proteins (BLTPs) facilitated the growth of a triple-negative breast cancer cell line and sustained its aggressiveness in an in vivo model of metastasis, suggesting that maintenance of plasma membrane fluidity by BLTP2 may be critical for tumorigenesis in humans.

[Nature Cell Biology] Investigators showed that autophagy normally suppresses breast cancer metastasis by enabling the clearance of NBR1–p62/SQSTM1 complexes that instruct p63-mediated pro-metastatic basal differentiation programs.

[Nature Cancer] Researchers demonstrated that p95HER2, a truncated form of human epidermal growth factor receptor 2 (HER2), drives immune evasion in HER2-positive female breast cancer, enhancing tumor growth and conferring therapy resistance.

[Nanoscale Horizons] Researchers investigated the development of pirarubicin and gemcitabine co-loaded polymeric nanoparticles for synergistic activity against breast cancer cells.

[Journal of Medicinal Chemistry] A series of diaryl piperidone-sulfonamide derivatives were designed as dual inhibitors of STAT3/CAIX and ferroptosis inducers for triple-negative breast cancer

[Molecular Oncology] The specificity of a chimeric cytotoxic peptide was confirmed in vitro by testing the cytotoxic activity of breast cancer cells overexpressing CCR5, a major CCL8 receptor, and by a neutralizing anti-CCL8 antibody they developed.

[Molecular Carcinogenesis] Macrophage type 1-derived extracellular vesicles were isolated and combined with PLGA nanoparticles loaded with the TLR3 agonist poly I:C as a therapeutic strategy to investigate their antitumor activity by downregulating tumor immune escape in the tumor microenvironment of breast cancer.

[Molecular and Cellular Biochemistry] The authors focus on the clinical applications of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in breast cancer progression, relapse, diagnosis, and treatment response.

[Susna G. Komen] Susan G. Komen^® commended the United States Supreme Court’s decision to overturn a lower court decision that threatened access to preventive breast care services, including screening mammography, risk-reducing medications for high-risk individuals, and genetic counseling and testing for some with a personal or family history of breast or related cancers.

[Nature Communications] Researchers analyzed the susceptibility of neural tissue to monkeypox virus using human neural organoids exposed to a clade IIb isolate. They reported susceptibility of several cell types to the virus, including neural progenitor cells and neurons.

[Cell] Scientists co-differentiated mesoderm and endoderm within the same spheroid to vascularize lung and intestinal organoids from iPSCs.

[Nature Biomedical Engineering] Investigators presented a method for generating jawbone-like organoids from hiPSC through PA1 ectomesenchyme of the mandibular prominence.