[Nature Communications] Scientists evaluated the efficacy of targeting procalcitonin for vascular integrity and sepsis outcomes. Sepsis up-regulates >2000 genes involved in pro-inflammatory responses while similar numbers of genes involving cell growth and maintenance are down-regulated.

[Nature Communications] Through single-cell RNA sequencing, colony-forming assays, and lineage tracing analysis, researchers provided data that point to a new regulatory system by which vascular endothelial cells are supplied to the retina by a reservoir of stem/progenitor cells in the optic nerve.

[Advanced Science] Investigators modified small extracellular vesicles with insulin-like growth factor-binding protein 7 to create a delivery platform that can deliver therapeutic agents to glioma-associated vascular endothelial cells with high efficiency.

[Proceedings of The National Academy of Sciences of The United States of America] Researchers defined the redox states of various subcellular locales in the vascular endothelium and demonstrate that NOX2 is responsible for cytosolic H₂O₂ signaling, whereas NOX4 contributes to H₂O₂ generation in the endoplasmic reticulum.

[Advanced Healthcare Materials] Scientists engineered 3D lymphatic microvessels by co-culturing human lymphatic endothelial cells with human bone marrow-derived mesenchymal stromal cells in synthetic and fully defined enzymatically crosslinked poly(ethylene glycol) hydrogels.

[Journal of Neuroinflammation] Investigators analyzed how age-related changes in blood components induce blood-brain barrier structure disruption and neurodegeneration using 6-month-old SAMP8 mice.

[Scientific Reports] The authors investigated the role of ATF4 in regulating mitochondrial dysfunction and mitophagy, which ultimately leads to corneal endothelial cell apoptosis.

[Cell Biochemistry and Function] Researchers hypothesized that activation of aldehyde dehydrogenase 2 (ALDH2) enhances nuclear factor kappa B (NFκB) signaling, thereby preventing the 4-hydroxy-2-nonenal (4HNE)-induced reduction in vascular endothelial growth factor receptor 2 (VEGFR2) expression and restoring angiogenesis.

[Development] Scientists summarize current understanding of blood–brain barrier development, including timing and underlying cellular and molecular mechanisms.

[The Association for Research in Vision and Ophthalmology (ARVO)] Dr. Rose Tan has been named the 2026 recipient of the ARVO Foundation Research Catalyst Award. Tan's current research focuses on characterizing chorioretinal microvasculature and neurodegenerative changes in diabetic retinopathy.

[Apoptosis] Researchers investigated whether combined N-acetylcysteine (NAC) and deoxyribonuclease I (DNase I) therapy mitigates severe acute pancreatitis and associated lung injury by suppressing neutrophil extracellular traps (NETs) formation and degradation, respectively, and explores the underlying molecular mechanisms.

[PLOS One] The authors evaluated whether microporation is a suitable technique for the transfection of pancreatic islets and whether the selected siRNA is recognized by islet cells as foreign, potentially triggering an inflammatory or cytotoxic response.