[Biogerontology] Investigators explored the possibility of inducing aging-associated features in cell types of the central nervous system using hiPSC technology.

[Journal Of Neuroscience] The authors reported using human tumor specimens and primary spheroids from male and female patients that GlialCAM, was differentially expressed in subpopulations of glioblastoma cells.

[Molecular Psychiatry] Investigators showed that the PTENG132D allele disrupted early neuroectoderm formation during the first several days of organoid generation, and results in deficient electrophysiology.

[Communications Biology] Scientists described a method for generating functional neural spheroids by cell-aggregation of differentiated human iPSC-derived neurons and astrocytes at cell type compositions mimicking specific regions of the human brain.

[Nature Communications] Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, the authors found that reduction in INPP5D activity was associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.

[Nature Communications] Scientists found increased expression of the C16:0 ceramide-producing ceramide synthase (CerS)6 in cultured hypothalamic neurons exposed to palmitate in vitro and in the hypothalamus of obese mice.

[Jama Network Open] This study included 234 consecutively identified patients with germline BRCA PVs and a diagnosis of PDAC. Of patients with BRCA1, 33 of 69 were males with a median age of 63 years. Of patients with BRCA2, 84 of 165 were males, and the median age was 64 years.

[Diabetes] Investigators discuss conflicting views of the relationship between pancreatic α-cells and β-cells and seek to understand how communication depends on blood flow and/or paracrine mechanisms.

[Scientific Reports] The authors utilized proteomics as a valuable approach for cancer biomarker discovery; therefore, mass spectrometry-based proteomic profiling was conducted on plasma samples from 12 subjects to identify potential proteins capable of effectively distinguishing PanNET from healthy controls.

[Journal Of Perinatology] Researchers retrospectively analyzed all ELGANs RBC Tx over the past three years, estimated local cord blood availability, and assesed interest in this project, and implementation barriers, through stakeholder surveys.

[Nature Microbiology] The authors re-analyzed a dataset which detected Streptococcus agalactiae DNA in the placenta in ~5% of women before the onset of labour as a case control study of neonatal unit admission.

[Cochrane Database Of Systematic Reviews] To evaluate the benefits and harms of stem cell‐based interventions for the treatment of stroke in newborn infants compared to control or stem‐cell based interventions of a different type or source.