Keep Current with the Latest in Cell Biology Research

An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness

[Small] Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.

Distinctive Mesenchymal-Like Neurofibroma Stem Cells Shape NF1 Clinical Phenotypes Controlled by BDNF Microenvironment

[Translational Oncology] Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cell from NF1 were isolated and cultured using fluorescence activated cell sorting and colony formation experiments.

METTL3 Facilitates Stemness Properties and Tumorigenicity of Cancer Stem Cells in Hepatocellular Carcinoma through the SOCS3/JAK2/STAT3 Signaling Pathway

[Cancer Gene Therapy] Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.

Targeting ABCA12-Controlled Ceramide Homeostasis Inhibits Breast Cancer Stem Cell Function and Chemoresistance

[Science Advances] Investigators developed a stem cell factor SOX9-based reporter for isolating CSCs in primary tumors and metastases of spontaneous mammary tumor models.

MiR-204 Suppresses Cancer Stemness and Enhances Osimertinib Sensitivity in Non-Small Cell Lung Cancer by Targeting CD44

[Molecular Therapy - Nucleic Acids] Scientists explored novel miRNA–mRNA regulatory mechanisms that contribute to osimertinib resistance in lung cancer. They found that miR-204 expression in osimertinib-resistant lung cancer cells was markedly reduced compared to that in osimertinib-sensitive parental cells.

An mTurq2-Col4a1 Mouse Model Allows for Live Visualization of Mammalian Basement Membrane Development

[Journal Of Cell Biology] Using an innovative planar-sagittal live imaging technique to visualize the basement membrane of developing skin, researchers directly observed basement membrane deformation during hair follicle budding and basal progenitor cell divisions.

The Role of APOBEC3B in Lung Tumor Evolution and Targeted Cancer Therapy Resistance

[Nature Genetics] Scientists studied the impact of the apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzyme APOBEC3B on epidermal growth factor receptor-driven lung cancer.

Ang-(1–7)/Mas Axis Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice via Restoration of Nox4-Nrf2 Redox Homeostasis

[European Journal Of Pharmacology] The angiotensin (Ang)-(1–7)-/Mas axis inhibited TGF-β1-induced lung fibroblast differentiation, inflammation, and fibrosis in bleomycin-treated lung tissue.

YAP1 Recognizes Inflammatory and Mechanical Cues to Exacerbate Benign Prostatic Hyperplasia via Promoting Cell Survival and Fibrosis

[Advanced Science] The correlation between YAP1 expression and fibrosis in human and rat benign prostatic hyperplasia specimens was analyzed, and the effects of YAP1 activation on prostatic cell survival and fibrosis, as well as the underlying mechanism, were also studied.

Prostate Lineage-Specific Metabolism Governs Luminal Differentiation and Response to Antiandrogen Treatment

[Nature Cell Biology] The authors developed an approach to perform metabolomics on primary prostate epithelial cells, and using this approach, discovered that the basal and luminal cells of the prostate exhibited distinct metabolomes and nutrient utilization patterns.

Mendelian Randomization Analyses Suggest a Causal Role for Circulating GIP and IL-1RA Levels in Homeostatic Model Assessment-Derived Measures of β-Cell Function and Insulin Sensitivity...

[Genome Medicine] Researchers evaluated associations between 11 circulating cytokines and hormones with T2D among a population of sub-Saharan Africans and tested for causal relationships using Mendelian randomization analyses.

Genetic Risk Converges on Regulatory Networks Mediating Early Type 2 Diabetes

[Nature] To identify early disease-driving events, researchers performed traditional and multiplexed pancreatic tissue imaging, sorted-islet cell transcriptomics and islet functional analysis of early-stage T2D and control donors.

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