[Molecular Therapy-Methods & Clinical Development] Researchers developed a lentiviral vector to restore adenosine deaminase 2 expression in patient hematopoietic stem and progenitor cells and evaluated its safety and efficacy in preclinical models.

[Blood Advances] The authors optimized ex vivo conditions in CD34⁺ hematopoietic stem and progenitor cells (HSPCs) and infused edited sickle cell disease HSPCs into busulfan-conditioned NBSGW mice.

[Toxicology] Researchers utilized a previously published NAM, which has been shown to develop cells from the myeloid and lymphoid immune lineages.

[Haematologica] Investigators found that TAK1 is required for the survival of hematopoietic stem/progenitor cells by restricting RIPK1 dependent and independent PANoptosis.

[Journal of Clinical Investigation] Scientists uncovered a novel role for LNK in regulating translesion synthesis during hematopoietic stem cell replication. Lnk deficiency reduced replication stress-associated DNA damage, particularly in the Fanconi anemia background.

[International Immunopharmacology] Zebrafish were used as a model organism to systematically investigate the potential effects of shikonin on hematopoiesis and the immune system.

[Clinical Epigenetics] Lineage-negative progenitor cells from NOP2/Sun RNA methyltransferase family member 2 (Nsun2) knockout and wild-type mice were used to generate BCR-ABL-driven murine B-acute lymphoblastic leukemia model.

[Journal of Clinical Investigation] The authors performed a genome-wide CRISPR interference screen of the strongest ETS1-dependent regulatory elements.

[Leukemia] Besides direct anti-B-cell efficacy, ibrutinib improves chemotherapy efficiency by reconstituting an effective immune system and enhancing immune cell control.

[Experimental Hematology] Scientists discuss the evidence that αβ T cell lineage decisions are not solely determined by thymic selection, and that hematopoietic origin also intrinsically biases development towards innate-like T cells in early life.

[Cellular & Molecular Biology Letters] The authors comprehensively summarize the expression patterns of inhibitor of DNA binding 1 (ID1) in hematopoietic and stromal cells within the bone marrow niche, and delve into its modulation of blood lineage commitment and development.

[Stem Cell Reviews and Reports] Investigators provide a systematic analysis of leukemic stem cell ferroptosis resistance and explore the interplay between iron metabolism, lipid peroxidation, and antioxidant defense mechanisms.