[Nature Aging] Scientists integrated single-nucleus transcriptomics and histological analyses to elucidate the aging mechanisms of the primate prostate.

[Journal of Translational Medicine] The authors investigated the biological significance of chromodomain helicase DNA binding protein 1-like (CHD1L) in prostate cancer and to evaluate the therapeutic potential of its selective inhibitor OTI-611.

[The Prostate] LRP2 showed subtype-specific expression patterns in prostate cancer, with elevated levels in DU-145 cancer stem cells and metastatic tumors.

[Chinese Medical Journal] The authors analyze the complex role of growth differentiation factor 15 (GDF15) in various aspects of prostate cancer, including metabolism, chemoresistance, metastasis, and clinical implications.

[A.D.A.M. Innovations, Co. ] A.D.A.M. Innovations, Co. announced the release of three new first-of-their-kind cancer prediction models for its GeneLife GeneAI Forecast platform: breast cancer, prostate cancer, and pancreatic cancer, developed using the largest Japanese population genetic database, improving relevance compared with Western-derived tools.

[Cancer Research] Using single-cell transcriptomic analysis and in situ profiling of primary tumors, metastases, and circulating tumor cells from multiple patients with breast cancer, investigators' identified a unique EPCAM⁺ CD68⁺ TREM2⁺ tumor subpopulation.

[Molecular Therapy] Scientists developed an aptamer-siRNA conjugate containing a transferrin receptor 1 aptamer linked to a CCAAT/enhancer-binding protein beta (C/EBPβ) siRNA.

[Cell Reports] Through 3D computational simulations and live video 3D imaging of primary mouse breast tumor organoids in a microfluidic device, researchers investigated the roles of type I cadherins during collective migration.

[Cell Death & Disease] Investigators revealed that TRIM25 effectively promoted cell proliferation, cell cycle progression, and paclitaxel chemoresistance of breast cancer cells.

[Oncogene] The authors presented evidence of a patient subset with EGFR amplification and PI3Kinase pathway mutations in breast cancer which can be synergistically targeted by dual EGFR/PI3K inhibition.

[npj Breast Cancer] Utilizing a large breast cancer cohort, scientists identified that increased METTL14 and CBLL1 expression was associated with a more favorable prognosis, whereas increased METTL3 expression was associated with poorer patient outcomes in TNBC.

[npj Breast Cancer] To uncover novel cancer susceptibility genes, researchers performed germline whole-exome/genome sequencing of samples from 564 patients with young-onset breast cancer, as well as samples from 4032 female controls.