[Scripps Research] Dr. Xin Jin, an associate professor at Scripps Research and a Freeman Hrabowski Scholar at Howard Hughes Medical Institute, has been awarded a Sloan Research Fellowship for her exceptional research and leadership in the field of neuroscience.

[Cell] Scientists developed a next-generation extracellular targeted protein degradation platform, synthetic peptide-programmed lysosome-targeting chimeras (SPYTACs), using entirely synthesized bispecific peptides.

[Nature Aging] Researchers observed a marked decline in the number of oligodendrocyte progenitor cells during aging, notably within the subpopulation highly expressing Acss2, which encodes acetyl-CoA synthetase 2 (ACSS2).

[Proceedings of the National Academy of Sciences of the United States of America] Investigators found that mitochondrial DNA leakage activates microglial immune signaling, which drives astrocytes into a hypermetabolic state and increases L-serine production.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists demonstrated that loss of TAR DNA-binding protein 43 (TDP-43) in neurons induces hypomyelination, and this impairment was rescued with the supplementation of cytoplasmic TDP-43 in neurons.

[Inflammation] The authors investigated the therapeutic potential and mechanism of action of the natural compound β-asarone in Alzheimer’s disease (AD) models. They elucidated that β-asarone ameliorates AD pathology by modulating microglial polarization.

[Neurochemical Research] Researchers examined how 6-hydroxydopamine (6-OHDA) affects iron homeostasis and inflammatory gene expression in MO3.13 oligodendrocytes. They demonstrated that 6-OHDA promotes iron accumulation in undifferentiated oligodendrocytes.

[Signal Transduction and Targeted Therapy] From the perspective of cancer neuroscience, scientists fully discuss the potential signaling molecules and their regulatory mechanisms, as well as targets and emerging therapeutic strategies that control tumor progression via multiomics approaches.

[Neuro-Oncology] The authors summarize current knowledge on mitochondrial exchange in glioblastoma via tunneling nanotubes, tumor microtubes, and potentially via extracellular vesicles.

[Journal of Translational Medicine] Investigators synthesizes emerging insights from single-cell and spatial transcriptomics to decode myeloid dynamics across distinct glioblastoma anatomical compartments.

[Biomaterials] Scientists presented a polyelectrolyte multilayer-based surface coating designed to promote rapid spheroid formation from individual cancer cells.

[Proceedings of The National Academy of Sciences of The United States of America] While scientists showed a strong molecular resemblance between Aging-luminal progenitors (ALPs) in aged normal tissue and ALP-like cancer cells, proving that ALPs are the normal cell-of-origin of ALP-like tumors remains to be established by future lineage-tracing experiments.