[Neurological Sciences] Investigators highlight the recent progress in the application of stem cell technologies, specifically the utilization of hiPSCs, for the treatment of Parkinson's disease.

[Nature Metabolism] Scientists identified lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity.

[Nucleic Acids Research] Researchers generated LIM domain-binding 1 (Ldb1)(-/-) ESCs using CRISPR/Cas9 editing and observed a reduction in key stem cell factors SOX2 and KLF4 upon LDB1 loss.

[Nature Communications] Investigators identified a direct interaction between NANOG, a master pluripotency transcription factor, and WDR5, a core chromatin regulator essential for maintaining stem cell identity.

[Nature Communications] The authors identified OTX2 as a key factor that establishes a repressive barrier to the induction of 8-cell-like cells from primed hPSCs.

[Science Advances] Using functional approaches on closely related primate species, investigators showed that XIST regulation has uniquely diverged over a short evolutionary timescale.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists introduced a microprobe capillary electrophoresis ion mobility mass spectrometry workflow that quantifies over one thousand proteins from opposite poles of a single Xenopus laevis blastomere before it divides to offspring cells with different tissue fates.

[Cell Reports] Researchers reported the molecular mechanisms underlying binding of the chromoshadow domain of HP1γ to the transcriptional co-repressor KAP1 and HP1γ self-assembly.

[EMBO Reports] Investigators showed that TFE3 mediates the transcriptional blockade induced by mTORC1 hyperactivation during reprogramming.

[elife] By leveraging optogenetic control of the Wnt signaling pathway in both HEK293T cells and H9 hESCs, scientists systematically mapped the relationship between signal frequency and downstream pathway activation.

[Journal of Cell Physiology] The authors reported that ENG knockout hPSCs maintain core pluripotency markers yet undergo spontaneous differentiation and exhibit markedly reduced potential to form mesoderm, ectoderm, and endoderm lineages.

[Advanced Biology] Scientists demonstrated that suppression of TERF2 robustly activates the DNA damage response, p53/p21 signaling, and cellular senescence in iPSCs in a highly homogeneous and synchronous manner.