[Experimental & Molecular Medicine] Evaluations of limb vitality, western blot, quantitative PCR, and immunofluorescence implicated that activation of Piezo1 exacerbates ischemia/reperfusion-induced microvascular perfusion deficits, tissue swelling, skeletal muscle damage and increased tissue infarction, and microvascular endothelial cell damage.

[Apoptosis] Scientists examined the effects of propofol on VEGFA-mediated angiogenesis in vitro and in vivo. Propofol triggers endoplasmic reticulum stress by promoting phosphorylation of protein kinase R-like endoplasmic reticulum kinase and its downstream effector eIF2α.

[King's College London] Researchers at King's College London have been awarded £2.1m in funding to take a new regenerative, cell-based therapy for leg pain caused by reduced blood flow to clinical trial.

[PloS One] Scientists investigated the role of TREM-1 in myocardial I/R injury and to explore the potential underlying molecular mechanisms.

[Acta Pharmacologica Sinica] Researchers developed a high-content screening assay based on DNA synthesis in human pluripotent stem cell-derived cardiomyocytes (CMs) to identify small molecules that could promote CM proliferation.

[Cell Death & Disease] Investigators used datasets from single-nuclei RNA sequencing of Duchenne Muscular Dystrophy muscle samples to study the dysregulation of molecular pathways compared to healthy control muscle.

[Circulation] Enhanced histone lactylation was linked to increased pyruvate dehydrogenase kinase 1 transcription, which accelerated lactate production in vascular smooth muscle cells.

[Circulation Research] Researchers defined the role of adenosine deaminase acting on RNA 1 (ADAR1)-dependent RNA editing in IFNβ activation in pulmonary arterial smooth muscle cells from idiopathic pulmonary arterial hypertension, a devastating disease leading to right heart failure and death.

[Cell Death Discovery] Primary vascular smooth muscle cells (VSMCs) were employed to investigate the role of USP13 on VSMC phenotype transition and potential mechanism.

[Skeletal Muscle] The authors introduce the concept and evidence for “non-regenerative myogenesis” in adult skeletal muscle and highlight its characteristics and the remaining research questions.

[Biogen, Inc.] Biogen, Inc. announced the European Commission has granted marketing authorization for a high dose regimen of SPINRAZA^®, which is comprised of 50 mg/5 mL and 28 mg/5 mL doses for the treatment of 5q spinal muscular atrophy.

[Cell Death & Disease] Investigators identified significant alterations in protein phosphorylation associated with CRC through tandem mass tag label-based phosphoproteomic analysis.