[Advanced Science] Researchers conducted proteomic analyses of human iPSC-derived motor neurons carrying C9ORF72 mutations, alongside spinal ventral horns from mice with pathogenic C9orf72-mutations.

[Nature Neuroscience] Investigators showed that 2-arachidonoylglycerol selectively signals to neurons, eliciting the depression, which is mediated exclusively by neuronal mechanisms.

[Nature Neuroscience] By examining spinal cord white matter tracts in mice, the authors determined that myelin degeneration was particularly prominent in the dorsal column during normal aging.

[Acta Pharmacologica Sinica] Scientists identified the cell type susceptible to α-synuclein-induced cellular senescence in the substantia nigra and investigated the specific role of microglia with a particular focus on the NLRP3 inflammasome.

[Stem Cell Reports] Using a conditional mouse model, we demonstrate that driving the expression of Spy1, in the Nestin-enriched NSC population of the brain, increases stemness characteristics, decreases differentiation, and increases susceptibility to oncogenic transformation.

[Science Advances] Investigators found that DMTF1, a transcription factor that regulates the Arf/p53 axis in cancer, is down-regulated in the NSCs of a premature aging model driven by telomerase deficiency.

[Advanced Science] Researchers presented an integrated microfluidic platform that addresses these limitations by enabling high-throughput generation of uniform hydrogel microparticles embedded with primary-derived human adult intestinal stem cells.

[Advanced Science] The authors identified a small nucleolar RNA Snord17 that is highly expressed in intestinal stem cells (ISCs). Snord17 knockout abrogates stemness of ISCs and impairs epithelial regeneration.

[Nature Communications] Endoglin (ENG) efficiently displaces prodomains from BMP9 and BMP10, enabling effective capturing of both ligands from the circulation, and binds to and recruits TGFBRII into the BMP9 signalling complex, thereby explaining ENG’s involvement in both TGF-β and BMP9 pathways.

[Cell Reports] Scientists showed that endothelial-specific deletion of p21-activated kinase 2 (PAK2) in orthotopic tumor mouse models markedly reduces tumor size and angiogenesis.

[Stem Cell Reports] To improve upon iPSC-based somatosensory disease models, investigators described the generation and validation of a genetic toolset to fluorescently label all or distinct somatosensory subtypes.

[Cell Death Discovery] Scientists demonstrated that ubiquitin C-terminal hydrolase L1 (UCHL1) is upregulated in NSCLC and drives tumor metastatic progression.