[Nature Communications] Scientists highlighted the importance of ECM protein induction in central nervous system glial cells during progressive multiple sclerosis while providing potential therapeutic targets for future investigation.

[Advanced Healthcare Materials] Investigators developed an injectable microgel scaffold composed of porcine liver-derived decellularized ECM and gelatin methacryloyl.

[Journal of Translational Medicine] Researchers created an efficient combined anti-tumor lipid nanoparticle (LNP) delivery system. They added DMG-PEG2000-FA to the four-component lipid nanoparticle system and used microfluidic technology to prepare FA-LNP with tumor-targeting groups.

[Stem Cell Research & Therapy] The authors characterized the cell type–specific miRNA–mRNA regulatory features of exosomes released by gingival fibroblasts, periodontal ligament fibroblasts, and dental pulp fibroblasts, and evaluated their potential links to mesenchymal stem cell-like molecular programs.

[Cell Death Discovery] In 3D spheroids, perfluorooctanoic acid disrupted spheroid morphology and the deposition of the organic component of ECM in a time-dependent manner.

[Development] Investigators showed that loss of the Caenorhabditis elegans lipocalin LPR-1 disrupts the assembly of another lipocalin, LPR-3, within the pre-cuticle apical ECM that protects and shapes the narrow excretory duct and pore tubes.

[Molecular Neurobiology] The authors provide a systematic review of the molecular mechanisms of muscle fibrosis in ALS. This included examining the dysregulation of transforming growth factor-β, connective tissue growth factor, and the Wnt/β-catenin signaling pathways.

[Boehringer Ingelheim] Boehringer Ingelheim announced the start of a Phase IIa clinical trial evaluating BI 765423, a novel monoclonal antibody targeting interleukin-11 (IL-11), in patients with idiopathic pulmonary fibrosis.

[Cell Stem Cell] Using feeder- and serum-free conditions, the authors found that CD4⁺ vs CD8⁺ T cell commitment from PSCs can be controlled by fine-tuning the dynamics of Notch and T cell receptor signaling delivered to CD4⁺CD8⁺ double-positive T cells.

[Cell Reports Methods] The authors described the engineering of T cell progenitors capable of direct and long-term reconstitution of the thymus. In the thymus, hPSC-derived progenitor T cells developed into single-positive human T cells that entered circulation and settled in the spleen.

[Genome Research] Investigators systematically studied microRNA alternative functions in mESCs by genetically deleting Drosha, leading to global loss of microRNAs.

[Stem Cells Translational Medicine] Researchers developed an iPSC-based metabolic dysfunction–associated steatotic liver disease risk predictor using functional lipid accumulation assessments.