[Cell Death & Disease] Investigators identified significant alterations in protein phosphorylation associated with CRC through tandem mass tag label-based phosphoproteomic analysis.

[MRM Health] MRM Health NV announced that the US FDA has granted clearance of its Investigational New Drug (IND) application for its lead program MH002. This enables the initiation of the STARFISH-ulcerative colitis Phase IIb clinical trial in patients with mild-to-moderate ulcerative colitis

[Alessa Therapeutics] Alessa Therapeutics announced that the US FDA has granted Fast Track designation for Enolen®, the Company’s lead product candidate for the treatment of low to intermediate risk, localized prostate cancer.

[Butterfly Medical (BioSpace)] Butterfly Medical, developer of a non-surgical solution for benign prostatic hyperplasia (BPH), announced the successful completion of the final 12-month follow-up for all patients in its international pivotal clinical study. The landmark study was designed to evaluate the safety and efficacy of the Butterfly Prostatic Retraction Device, a first-line interventional therapy for BPH.

[JAMA Oncology] In this cohort study with a target trial emulation design, sodium-glucose cotransporter 2 (SGLT2) inhibitor use was associated with delayed hormone therapy failure in patients with prostate cancer, suggesting a potential oncologic benefit beyond glucose lowering.

[Nature Microbiology] Researchers developed a 2D mouse stem cell-derived prostate epithelial organoid model. In the organoid model, 5α-dihydrotestosterone promoted differentiation of basal into luminal cells, while transcriptomic analyses validated the model in comparison to 3D models and mouse prostate tissue.

[Proceedings of the National Academy of Sciences of the United States of America] Overexpression of TMEM267, which encodes a transmembrane protein overexpressed in 22% of TP53 missense mutant breast cancer cases, in cells with mutant TP53 caused a significant increase in the filled duct, DCIS-like phenotype.

[Cell Death & Differentiation] Functional assays demonstrated that tRNA methyltransferase activator subunit 11-2 (TRMT112) knockdown in TNBC cells significantly reduces proliferation, migration, invasion, and metastatic potential, whereas its overexpression enhanced these tumorigenic properties.

[JCI Insight] Researchers found that 14-3-3ε facilitates NLRP3 inflammasome activation by enhancing NLRP3 K63 deubiquitination and promoting its translocation to the mitochondria-associated ER membranes for full activation.

[JCI Insight] Researchers examined acute phase immune and virological dynamics in cohorts of SIV-infected rhesus macaques that were naturally seropositive or -negative for rhesus CMV (RhCMV).

[Nature Communications] The authors identified buytyrophilin 2A2 (BTN2A2) as a modulator of CD45RO signaling in T cells, providing insight into how BTN2A2 regulates T cell-dependent immune responses including those mediating autoimmunity and transplant rejection.

[Cell Death & Disease] Researchers investigated the specific mechanism by which Piezo1 mediates autophagy to regulate the immune-inflammatory response in ankylosing spondylitis.