[Cellular & Molecular Immunology] Increasing knowledge on neutrophil behavior in the context of chronic inflammation may offer novel insights into disease pathology and, potentially, the identification of novel therapeutic targets.

[Nature Communications] Scientists showed that combined treatment with a RAS/PI3K/AKT-pathway inhibitor rigosertib, and/or a MEK1/2 inhibitor trametinib, plus aCD40, overcomes the immune checkpoint blockade resistance of BRAFwtNRASwt and BRAFwtNRASmut melanoma tumors growing in C57BL/6 mice.

[Nature Immunology] Investigators found that follicular regulatory T cells undergo progressive differentiation through progenitor, early effector, and late effector stages.

[Nature Communications] Researchers described monovalent and bivalent replicon vaccines against A/Vietnam/1203/2004 H5N1 and A/Anhui/PA-1/2013 H7N9.

[Cellular & Molecular Immunology] Investigators revealed a dynamic regulatory network involving lactylation–delactylation of TANK binding kinase 1 (TBK1), a pivotal kinase of IFN-I signaling, that finely tunes antiviral immune responses.

[Nature Communications] The authors showed that intramuscular prime-boost vaccination with Alum-absorbed OMV46-LcrV is safe but provides limited long-term protection against respiratory Yersinia pestis challenge in mice.

[International Journal of Oral Science] Scientists revealed a distinct NKD1+ subpopulation exhibiting secretory odontoblast characteristics, which was specifically induced in dental pulp stem cells by Wnt3a, but not by Wnt5a or Wnt10a through single-cell transcriptomic profiling.

[Leukemia] Investigators demonstrated that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs).

[Leukemia] The first-in-class, direct, competitive telomerase inhibitor, imetelstat, demonstrated higher rates of red blood cell (RBC) transfusion independence versus placebo in patients with non-del(5q), RBC transfusion-dependent lower-risk myelodysplastic syndromes/neoplasms who were relapsed/refractory to or ineligible for erythropoiesis-stimulating agents in the Phase III IMerge study.

[Scientific Reports] The authors discovered that LINC00324 is involved in regulating autophagy in melanoma and may serve as a suitable new target for inhibiting melanoma progression.

[Nature Communications] Investigators showed that SOX2 overexpression, along with MAPK activation, in progenitors induces a stem-like state and renders this otherwise resistant population permissive to rapid transformation.

[Nature Medicine] Scientists leveraged advances in single-cell transcriptomics to delineate inflammatory processes of circulating immune cells during infection, immune-mediated inflammatory diseases, and cancer.