Endothelial Cell News Volume 7.15 | May 2 2022

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    2022-05-02 | ENDOCN 7.15


    Endothelial Cell News by STEMCELL Technologies
    Vol. 7.15 – 2 May, 2022
    TOP STORY

    Identification of a Retinoic Acid-Dependent Hemogenic Endothelial Progenitor from Human Pluripotent Stem Cells

    Researchers showed that WNT-dependent mesoderm, before hemogenic endothelium specification, was actually composed of two distinct KDR+ CD34neg populations.
    [Nature Cell Biology]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Endothelial Cells Mediated by UCP2 Control the Neurogenic-to-Astrogenic Neural Stem Cells Fate Switch during Brain Development

    Scientists provided mechanistic insights into how endothelial uncoupling protein 2 regulated the neurogenic-to-gliogenic fate switch in the developing neocortex.
    [Advanced Science]

    Full Article

    Small-World Connectivity Dictates Collective Endothelial Cell Signaling

    The authors revealed that the endothelial network design was effective for local and global efficiency in the interaction of the cells and rapid and robust communication between endothelial cells in order to efficiently control cardiovascular activity.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    JAK Inhibitor Blocks COVID-19-Cytokine-Induced JAK-STAT-APOL1 Signaling in Glomerular Cells and Podocytopathy in Human Kidney Organoids

    Based on nine biopsy-proven COVAN cases, researchers demonstrated for the first time that APOL1 protein was abundantly expressed in podocytes and glomerular endothelial cells of COVAN kidneys but not in controls.
    [JCI Insight]

    Abstract

    HIF1A Promotes miR-210/miR-424 Transcription to Modulate the Angiogenesis in HUVECs and HDMECs via sFLT1 under Hypoxic Stress

    HIF1A is a key regulatory of the recovery of intracellular homeostasis under hypoxia. Scientists investigated the detailed role and mechanism of HIF1A in the angiogenesis under hypoxia
    [Molecular & Cellular Proteomics]

    Abstract

    Quercetin Regulates Vascular Endothelium Function in Chronic Renal Failure via Modulation of Eph/Cav-1 Signaling

    Researchers uncovered the impacts of Quercetin on vascular endothelial cells in a chronic renal failure (CRF) rat model and HUVECs stimulated by lipopolysaccharide and serum from a rat with CRF.
    [Drug Development Research]

    Abstract

    CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells via Activating Akt/eNOS Pathway and Promotes Ischemic Angiogenesis in Diabetic Limb Ischemia

    Scientists investigated whether and how CXCR7 agonist TC14012 promoted the angiogenic function of diabetic endothelial progenitor cells .
    [Cardiovascular Drugs and Therapy]

    Abstract

    AT2R Activation Increases In Vitro Angiogenesis in Pregnant Human Uterine Artery Endothelial Cells

    Researchers examined whether or not angiotensin type 2 receptor (AT2R) activation induced angiogenesis and, if so, what mechanisms were involved.
    [PLoS One]

    Full Article

    Expression of Vimentin, TPI and MAT2A in Human Dermal Microvascular Endothelial Cells during Angiogenesis In Vitro

    The authors analyzed expression profiles of vimentin, triosephosphate isomerase (TPI) and adenosylmethionine synthetase isoform type–2 (MATA2) during the whole angiogenic cascade in vitro.
    [PLoS One]

    Full Article

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    REVIEWS

    Direct and Indirect Regulation of the Tumor Immune Microenvironment by VEGF

    Investigators discuss the direct and indirect effects of VEGF on the immunosuppressive tumor microenvironment with a particular focus on the direct regulation of immune cells through VEGFR2 activity.
    [Journal of Leukocyte Biology]

    Abstract

    INDUSTRY AND POLICY NEWS

    HUTCHMED Receives Complete Response Letter from the US FDA for Surufatinib for the Treatment of Advanced Neuroendocrine Tumors

    HUTCHMED Limited announced that the US FDA has issued a Complete Response Letter regarding the New Drug Application for surufatinib for the treatment of pancreatic and extra-pancreatic neuroendocrine tumors.
    [HUTCHMED Limited]

    Press Release

    FEATURED EVENT

    Keystone Symposia – Tissue Fibrosis and Repair

    June 12 – 16, 2022
    Colorado, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immuno-Oncology/Vascular Biology Research

    Johns Hopkins University School of Medicine – St. Petersburg, Florida, United States

    Postdoctoral Fellowship – Microvasculature of Organs

    University of Lausanne – Lausanne, Switzerland

    Post-Doctoral Fellow – Vascular/Endothelial Cell Biology

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Research Fellowship – Endothelial Basis of Cardiovascular and Metabolic Disease

    University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – In Vitro Vascular Models

    European Molecular Biology Laboratory – Barcelona, Spain

    > See All Jobs

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