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Britya Ghosh

Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells

[Cell Death & Disease] Scientists demonstrated that cAMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.

GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis

[Oncogenesis] Researchers found that GSK3β was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.

ΔNp63α Mediates Sulforaphane Suppressed Colorectal Cancer Stem Cell Properties through Transcriptional Regulation of Nanog/Oct4/Sox2

[Journal of Nutritional Biochemistry] Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.

Identification of Two Cancer Stem Cell-Like Populations in Triple-Negative Breast Cancer Xenografts

[Disease Models & Mechanisms] The multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis, two of which were CSC-like clusters.

GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer

[Frontiers in Pharmacology] Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.

Recombinant Expression a Novel Fibronectin—Collage Fusion Peptide Modulating Stem Cell Stemness via Integrin β3

[Applied Microbiology and Biotechnology] A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.

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Clinical Implications of Wnt Pathway Genetic Alterations in Men with Advanced Prostate Cancer

[Prostate Cancer and Prostatic Diseases] Investigators utilized the Prostate Cancer Precision Medicine Multi-Institutional Collaborative Effort clinical-genomic database for this retrospective analysis.

Targeting Valine Catabolism to Inhibit Metabolic Reprogramming in Prostate Cancer

[Cell Death & Disease] Through the suppression of branched-chain amino acid (BCAA) availability, researchers reported significantly reduced lipid content, strongly indicating that BCAAs were important lipogenic fuels in prostate cancer.

Embryonic Microenvironment Suppresses YY1 and YY1-Related Genes in Prostate Cancer Stem Cells

[Pathology - Research and Practice] To investigate the embryonic microenvironment impact on Yin yang 1 (YY1) expression in CSC populations, firstly cancer stem cells (CSCs) were microinjected into the inner cell mass of blastocysts and then prostate CSCs were co-cultured with blastocysts.