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Britya Ghosh
Cancer Stem Cell News
Disruption of β-Catenin-Mediated Negative Feedback Reinforces cAMP-Induced Neuronal Differentiation in Glioma Stem Cells
[Cell Death & Disease] Scientists demonstrated that cAMP triggered neuronal differentiation and compromised the self-renewal capacity in glioma stem cells.
Cancer Stem Cell News
GSK3β Palmitoylation Mediated by ZDHHC4 Promotes Tumorigenicity of Glioblastoma Stem Cells in Temozolomide-Resistant Glioblastoma through the EZH2–STAT3 Axis
[Oncogenesis] Researchers found that GSK3β was noted as a substrate for ZDHHC4-mediated palmitoylation at the Cys14 residue, which enhanced glioblastoma temozolomide resistance and glioblastoma stem cell self-renewal.
Cancer Stem Cell News
ΔNp63α Mediates Sulforaphane Suppressed Colorectal Cancer Stem Cell Properties through Transcriptional Regulation of Nanog/Oct4/Sox2
[Journal of Nutritional Biochemistry] Scientists showed that ΔNp63α expression was enhanced in sphere-forming colorectal cancer cells.
Cancer Stem Cell News
Identification of Two Cancer Stem Cell-Like Populations in Triple-Negative Breast Cancer Xenografts
[Disease Models & Mechanisms] The multiple-microtissue transcriptome analysis revealed three cancer cell-type clusters in the primary tumor and axillary lymph node metastasis, two of which were CSC-like clusters.
Cancer Stem Cell News
GM-CSF-miRNA-Jak2/Stat3 Signaling Mediates Chemotherapy-Induced Cancer Cell Stemness in Gastric Cancer
[Frontiers in Pharmacology] Researchers treated two human gastric cancer cell lines SGC7901 and BGC823 with 5-Fluorouracil or Cisplatin in vitro.
Cancer Stem Cell News
Recombinant Expression a Novel Fibronectin—Collage Fusion Peptide Modulating Stem Cell Stemness via Integrin β3
[Applied Microbiology and Biotechnology] A novel recombinant protein fibronectin-collagen peptide was designed to modulate the function of extracellular matrix expressed by Picha. pastoris strain X33.
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PARP11 Inhibition Inactivates Tumor-Infiltrating Regulatory T Cells and Improves the Efficacy of Immunotherapies
[Cell Reports Medicine] Scientists demonstrated that poly-(ADP-ribose)-polymerase-11 (PARP11) is an essential regulator of immunosuppressive activities of tumor-infiltrating regulatory T cells.
PD-1/LAG-3 Co-Signaling Profiling Uncovers CBL Ubiquitin Ligases as Key Immunotherapy Targets
[EMBO Molecular Medicine] To identify shared features associated to PD-1/LAG-3 dysfunctionality in human cancers and T cells, multiomic expression profiles were obtained for all TCGA cancers immune infiltrates.
Mucosal Signatures of Pathogenic T Cells in HLA-B*27+ Anterior Uveitis and Axial Spondyloarthritis
[JCI Insight] Investigators identified a bacterial peptide that could be presented by HLA-B*27 to expanded public T cell receptors in the joint in axSpA and the eye in B27AAU.