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TOP STORY |
Reduced-Intensity Conditioning and HLA-Matched Hemopoietic Stem-Cell Transplantation in Patients with Chronic Granulomatous Disease: A Prospective Multicenter Study In chronic granulomatous disease allogeneic hemopoietic stem-cell transplantation in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease, and transplant-related mortality. Researchers examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients. [Lancet] Abstract | Press Release |
PUBLICATIONS (Ranked by impact factor of the journal) |
Human Induced Pluripotent Stem Cell-Derived Cortical Neurons Integrate in Stroke-Injured Cortex and Improve Functional Recovery At two months after transplantation into a stroke-damaged rat cortex, cortically fated cells showed less proliferation and more efficient conversion to mature neurons with morphological and immunohistochemical characteristics of a cortical phenotype and higher axonal projection density as compared with non-fated cells. [Brain] Abstract | Press Release Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony Forming Cells TRIM5α Variations Influence Transduction Efficiency with Lentiviral Vectors in Both Human and Rhesus CD34+ Cells In Vitro and In Vivo Stem Cells Derived from Tooth Periodontal Ligament Enhance Functional Angiogenesis by Endothelial Cells Transplantation of Insulin-Secreting Cells Differentiated from Human Adipose Tissue-Derived Stem Cells into Type 2 Diabetes Mice Mesenchymal Stem Cells and Endothelial Progenitor Cells Stimulate Bone Regeneration and Mineral Density Improved Preparation of Acellular Nerve Scaffold and Application of PKH26 Fluorescent Labeling Combined with In Vivo Fluorescent Imaging System in Nerve Tissue Engineering mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo |
REVIEWS |
Mesenchymal Stem Cells Improve Locomotor Recovery in Traumatic Spinal Cord Injury: Systematic Review with Meta-Analyses of Rat Models Investigators performed a systematic review with quantitative syntheses to assess the evidence of mesenchymal stem or stromal cells versus controls for locomotor recovery in rat models of traumatic spinal cord injury, and identified 83 eligible controlled studies comprising a total of 1,568 rats. [Neurobiol Dis] Abstract Key Action Items for the Stem Cell Field: Looking Ahead to 2014 Concise Review: Stem Cell Therapy for Muscular Dystrophies Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field. |
SCIENCE NEWS |
Sangamo BioSciences Presents Clinical Data from HIV Study Demonstrating Sustained Control of Viremia Sangamo BioSciences, Inc. announced the presentation of new data demonstrating sustained control of HIV viral load at or below the limit of detection for 14 weeks (at last measurement) in an SB-728-T- treated HIV-infected subject who was not on antiretroviral therapy (ART). [Press release from Sangamo BioSciences, Inc. discussing research presented at the Annual Meeting of the European Society of Gene and Cell Therapy (ESGCT), Madrid] Press Release Juventas Therapeutics Completes Enrollment of Phase II STOP-HF Study of JVS-100 in Patients with Symptomatic Heart Failure |
POLICY |
NIH Reverses Course, Will Move Up Peer-Review Meetings Responding to an outcry from researchers, the National Institutes of Health (NIH) has revised its plan to delay more than 200 grant application review meetings canceled by the 1 to 16 October government shutdown. [ScienceInsider] Editorial India’s Supreme Court Mandates Videotaped Consent in Clinical Trials U.N. Names New Science Advisory Board |
BUSINESS |
STEMSOFT Licenses StemLab Software to TUMCells STEMSOFTâ„¢ Software Inc. (STEMSOFT) announced the licensing of StemLabâ„¢, the leading cell therapy transplant laboratory software, to TUMCells Interdisziplinäres Zentrum für zelluläre Therapien Technische Universität München (TUMCells) at the University Hospital Klinikum rechts der Isar in Germany. [STEMSOFT Software Inc.] Press Release PharmaCell Announces Agreement to Be – The European Contract Manufacturing Organization for Dendreon Bioheart Announces Agreement with Anosis to Distribute Products in the Middle East Medical Research Council Award Puts Bristol on the Map for Regenerative Medicine Imaging The Leukemia & Lymphoma Society Announces Recipients of the New Idea Award Grant Program BioTime Reports Interim Results on Reneviaâ„¢ Clinical Safety Trial Mesoblast Updates Market on Registration Plans for GvHD Cell Product in Japan UW Expands Stem Cell Research to Waisman Center |
NIH |
Center for Scientific Review; Amended Notice of Meeting (FR Doc No: 2013-25034) |
CBER |
Draft Guidance for Industry: Use of Nucleic Acid Tests to Reduce the Risk of Transmission of West Nile Virus from Donors of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) |
REGULATORY |
Food and Drug Administration (United States) Clinical Investigator Training Course (FR Doc No: 2013-25127) European Medicines Agency (European Union) Meeting Highlights from the Committee for Medicinal Products for Human Use (CHMP) 21-24 October 2013 |
EVENTS |
NEW Simplify Your Cellular Therapy Lab Processes October 31, 2013 11:00 AM (CST) Webinar NEW The Activated Egg 2013 NEW Cell Therapies for Parkinson’s Disease Webinar Visit our events page to see a complete list of events in the cell, gene and immunotherapy community. |
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