Justin.choi

Umbilical & Placental Cell News

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Umbilical & Placental Cell News

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Umbilical & Placental Cell News

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologics™ (PR NewsWire, Inc.)] Essent Biologics™ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.

Mammary Cell News

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Mammary Cell News

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

Mammary Cell News

LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

[npj Breast Cancer] Researchers identified 1127 lncRNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.

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Type 2 Diabetes Mellitus in Adults: Pathogenesis, Prevention, and Therapy

[Signal Transduction and Targeted Therapy] Scientists summarize the underlying mechanism, screening, diagnosis, prevention, and treatment of type 2 diabetes, especially regarding the personalized selection of hypoglycemic agents and holistic management based on the concept of metabolic syndrome-related target organ damage.

Circular RNA-Encoded Oncogenic PIAS1 Variant Blocks Immunogenic Ferroptosis by Modulating the Balance Between SUMOylation and Phosphorylation of STAT1

[Molecular Cancer] The impact of circPIAS1-108aa on the ferroptosis process of melanoma cells was studied through glutathione, malondialdehyde, and C11-BODIPY staining assays. Proliferation changes in melanoma cells were assessed using cell counting Kit-8, EdU, and colony formation assays.

IRF2 Loss Is Associated with Reduced MHC I Pathway Transcripts in Subsets of Most Human Cancers and Causes Resistance to Checkpoint Immunotherapy in Human...

[Journal of Experimental & Clinical Cancer Research] CRISRPcas9 was used to knock out IRF1 and IRF2 genes in human and mouse melanoma cells and the resulting phenotypes were analyzed in vitro and in vivo.

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