[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.
[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.
[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.
[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.
[Placenta] Utilizing human models including in vitro and ex vivo scientists demonstrated robust nanoparticle uptake, transgene expression, nutrient transporter regulation without transfer to the fetus.
[Molecular Therapy] Researchers review the latest advancements in improving the delivery of different therapeutic agents to the central nervous system and comment upon outstanding questions in the field of neurological lysosomal storage diseases.
[Nature Genetics] Investigators performed an integrated analysis of 116 tumors, including single-cell transcriptome and chromatin accessibility, 3D chromatin architecture, and epigenomic profiles, and showed that K27M-mutant gliomas faithfully maintain chromatin configuration at developmental genes consistent with anatomically distinct oligodendrocyte precursor cells.
[Nature Communications] Researchers showed that the RNA-binding protein, Musashi-1 is an essential mediator of G3 medulloblastoma in both MYC-overexpressing mouse models and patient-derived xenografts.