Justin.choi

Umbilical & Placental Cell News

Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Umbilical & Placental Cell News

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Umbilical & Placental Cell News

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologics™ (PR NewsWire, Inc.)] Essent Biologics™ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.

Mammary Cell News

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Mammary Cell News

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

Mammary Cell News

LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

[npj Breast Cancer] Researchers identified 1127 lncRNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.

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NCI Grant-Funded Study at Ohio State to Focus on Resistance to AML Treatment in Older Adults

[OSUCCC] A five-year, $3.46 million grant from the National Cancer Institute was awarded to The Ohio State University Comprehensive Cancer Center (OSUCCC) and the University of California San Francisco (UCSF). The grant will help researchers study why some patients with AML respond to treatment while others don't.

Venetoclax plus Inotuzumab Ozogamicin for Relapsed and Refractory Acute Lymphoblastic Leukemia

[Blood] Based on preclinical evidence of synergy, researchers conducted a Phase I trial of the BCL-2 inhibitor venetoclax plus standard-dose inotuzumab ozogamicin for adults with relapsed or refractory CD22⁺ acute lymphoblastic leukemia/lymphoblastic lymphoma.

Melatonin, Circadian Metabolism, Mitochondrial Remodeling, and Cell Size Dynamics in Primitive Hematopoietic Stem Cells

[Blood] Researchers showed that circadian cues coordinated a program of mitochondrial remodeling, metabolic reprogramming, and structural adaptation in primitive HSCs.

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Justin.choi

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