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Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologics™ (PR NewsWire, Inc.)] Essent Biologics™ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

[npj Breast Cancer] Researchers identified 1127 lncRNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.


The Role and Mechanism of Engineered Nanovesicles Derived from Hair Follicle Mesenchymal Stem Cells in the Treatment of UVB-Induced Skin Photoaging

[Journal of Cosmetic Dermatology] Ultraviolet radiation B (UVB)-induced photoaging nude mice and human dermal fibroblasts were used as experimental models to investigate the therapeutic effects of cell-derived nanovesicles from hair follicle mesenchymal stem cells in photoaging models.

Transcription Factor Activating Enhancer-Binding Protein 2ε (AP2ε) Modulates Phenotypic Plasticity and Progression of Malignant Melanoma

[Cell Death & Disease] Using a transgenic melanoma mouse model with a specific loss of AP2ε expression, researchers confirmed the impact of AP2ε to modulate the dynamic switch from a migratory to a proliferative phenotype.

Anti-EGFR Antibody-Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth

[Clinical Cancer Research] Expression of G1/S-phase cell cycle regulators were evaluated alongside EGFR in breast cancer. The authors conjugated cetuximab with CDK inhibitor SNS-032, for specific delivery to EGFR-expressing cells and assessed antibody drug conjugate internalization, and its anti-tumor functions in vitro and in orthotopically-grown basal-like/TNBC xenografts.