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Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Interventions for Placental Insufficiency and Fetal Growth Restriction

[Placenta] Utilizing human models including in vitro and ex vivo scientists demonstrated robust nanoparticle uptake, transgene expression, nutrient transporter regulation without transfer to the fetus.

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologics™ (PR NewsWire, Inc.)] Essent Biologics™ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.


TMEM16E Regulates Endothelial Cell Procoagulant Activity and Thrombosis

[Journal Of Clinical Investigation] Researchers employed a focused genetic screen to evaluate the contribution of transmembrane phospholipid transport on endothelial cell (EC) procoagulant activity. They identified two TMEM16 family members, TMEM16F and TMEM16E, which were both required to support coagulation on ECs via phosphatidylserine externalization.

Fabrication of CO-releasing Surface to Enhance the Blood Compatibility and Endothelialization of TiO2 Nanotubes on Titanium Surface

[Biomaterials Advances] The regular titanium dioxide (TiO2) nanotube arrays were firstly prepared in situ on the titanium surface by anodic oxidation, followed by the immobilization of the complex of sodium alginate/carboxymethyl chitosan on the self-assembled modified nanotube surface.

Breast Tumors Interfere with Endothelial TRAIL at the Premetastatic Niche to Promote Cancer Cell Seeding

[Science Advances] Investigators found that endothelial cells at the premetastatic niche coexpress tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5.