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Large-Scale Analysis of MicroRNA Expression in Motor Neuron-Like Cells Derived from Human Umbilical Cord Blood Mesenchymal Stem Cells

[Scientific Reports] Human CB-MSCs were isolated and characterized using flow cytometry. Cell differentiation has been induced by combining retinoic acid and sonic hedgehog in a two-step protocol for 14 days.

Human Placental Development and Function

[Seminars in Cell & Developmental Biology] Scientists examine current knowledge of early human placental development, discuss the critical role of the maternal endometrium and of the fetal-maternal dialogue in pregnancy success, and they explore the latest models of trophoblast and endometrial stem cells.

Essent Biologics Launches Human Mesenchymal Stem Cells for Regenerative Medicine, Biopharmaceutical and Cell Therapy Research

[Essent Biologics™ (PR NewsWire, Inc.)] Essent Biologics™ announced the launch of its human mesenchymal stem cells for regenerative medicine, biopharmaceutical and cell therapy research.

H3K27me3 Conditions Chemotolerance in Triple-Negative Breast Cancer

[Nature Genetics] By monitoring epigenomes, transcriptomes and lineages with single-cell resolution, scientists showed that the repressive histone mark trimethylation of histone H3 at lysine 27 (H3K27me3) regulated cell fate at the onset of chemotherapy.

Progesterone Activates GPR126 to Promote Breast Cancer Development via the Gi Pathway

[Proceedings of the National Academy of Sciences of the United States of America] Scientists identified a membrane receptor for progesterone/17-hydroxyprogesterone and delineated the mechanisms by which GPR126 participated in potential tumor progression in TNBC.

LINC00355 Regulates p27KIP Expression by Binding to MENIN to Induce Proliferation in Late-Stage Relapse Breast Cancer

[npj Breast Cancer] Researchers identified 1127 lncRNAs differentially expressed in late-stage relapse (LSR) breast cancer (BC) via transcriptome sequencing and analysis of 72 early-stage and 24 LSR BC patient tumors.


An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness

[Small] Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.

Distinctive Mesenchymal-Like Neurofibroma Stem Cells Shape NF1 Clinical Phenotypes Controlled by BDNF Microenvironment

[Translational Oncology] Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cell from NF1 were isolated and cultured using fluorescence activated cell sorting and colony formation experiments.

METTL3 Facilitates Stemness Properties and Tumorigenicity of Cancer Stem Cells in Hepatocellular Carcinoma through the SOCS3/JAK2/STAT3 Signaling Pathway

[Cancer Gene Therapy] Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.