Justin.choi

[Hereditary Cancer in Clinical Practice] Scientists provide a review of the emerging preclinical and epidemiologic evidence implicating the dysregulation of progesterone-mediated receptor activator of nuclear factor κB signaling in the pathogenesis of BRCA1-associated breast cancer.

[Clinical and Translational Medicine] Investigators explored the impacts of prostate cancer-associated ncRNA transcripts 1 (PCAT1) on tumorigenesis and radioimmune responses and the underlying molecular mechanisms in NSCLC.

[Cell Reports] The authors transplanted organoid cells derived from alveolar type II cells enriched by SCA1-negative status or multipotent SCA1-positive progenitor cells into injured mouse lungs.

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

[Clinical Cancer Research] A retrospective database query identified patients with KRAS-mutant NSCLC to understand their propensity to develop brain metastases.

[Journal For Immunotherapy of Cancer] Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8+CD103+ TRM cells for more efficient anticancer treatments.