Justin.choi

Mammary Cell News

Delineating the Role of Osteoprotegerin as a Marker of Breast Cancer Risk among Women with a BRCA1 Mutation

[Hereditary Cancer in Clinical Practice] Scientists provide a review of the emerging preclinical and epidemiologic evidence implicating the dysregulation of progesterone-mediated receptor activator of nuclear factor κB signaling in the pathogenesis of BRCA1-associated breast cancer.

Pulmonary Cell News

LncRNA PCAT1 Activates SOX2 and Suppresses Radioimmune Responses via Regulating cGAS/STING Signaling in Non-Small Cell Lung Cancer

[Clinical and Translational Medicine] Investigators explored the impacts of prostate cancer-associated ncRNA transcripts 1 (PCAT1) on tumorigenesis and radioimmune responses and the underlying molecular mechanisms in NSCLC.

Pulmonary Cell News

Progenitor Potential of Lung Epithelial Organoid Cells in a Transplantation Model

[Cell Reports] The authors transplanted organoid cells derived from alveolar type II cells enriched by SCA1-negative status or multipotent SCA1-positive progenitor cells into injured mouse lungs.

Pulmonary Cell News

Caspase-9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

[Molecular Cancer Research] A transgenic mouse model expressing human Caspase-9b in the lung pneumocytes developed inflammatory lung lesions, which correlated with enhanced activation of the NF-κB pathway and increased influx of immunosuppressive MDSCs in contrast to wild-type mice.

Pulmonary Cell News

Activity of Adagrasib (MRTX849) in Brain Metastases: Preclinical Models and Clinical Data from Patients with KRASG12C-Mutant Non-small Cell Lung Cancer

[Clinical Cancer Research] A retrospective database query identified patients with KRAS-mutant NSCLC to understand their propensity to develop brain metastases.

Pulmonary Cell News

Cancer Stem-Like Cells Evade CD8+CD103+ Tumor-Resident Memory T (TRM) Lymphocytes by Initiating an Epithelial-to-Mesenchymal Transition Program in a Human Lung Tumor Mode

[Journal For Immunotherapy of Cancer] Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8+CD103+ TRM cells for more efficient anticancer treatments.

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PLD1 and PLD2 Promote an Immunosuppressive Tumor Microenvironment via CCL19-Dependent Macrophage Polarization and PD-L1 Induction

[Experimental & Molecular Medicine] Researchers demonstrated that both genetic ablation and pharmacological inhibition of phospholipase D (PLD) 1 and PLD2 reprogram the tumor microenvironment and enhance antitumor immunity in a syngeneic melanoma model.

Rise Therapeutics Completes Enrollment in Four-Week Dose Expansion Cohort for the R-2487 Rheumatoid Arthritis Clinical Trial

[Rise Therapeutics] Rise Therapeutics announced the completion of full enrollment in the four-week dose expansion cohort of its Phase Ib clinical trial evaluating orally dosed R-2487 in patients with active rheumatoid arthritis. R-2487 is a synthetic biology-based immunotherapy designed to address underlying immune dysfunction in autoimmune diseases.

From Tregs to Tissue Remodelling: FOXP3 and IL-35 in the Inflammatory Landscape of Nasal Polyps

[Inflammation Research] The authors examine how Tregs release the potent immunosuppressive cytokine IL-35, suppressing effector T cell responses and encouraging Treg proliferation. Studies have shown that IL-35 is essential for preserving immunological homeostasis.

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Justin.choi

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