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[Nature Biomedical Engineering] Scientists developed a programmable RNA engineering platform, termed the 3′UTR CRISPR/dCas13 Engineering System, to precisely manipulate mRNA alternative polyadenylation in vivo.

[UCLA Health] Researchers from the UCLA Health Jonsson Comprehensive Cancer Center have received a $1.7 million grant from the US Department of Defense’s Congressionally Directed Medical Research Programs to develop new strategies to improve CAR T-cell therapies for metastatic CRPC.

[Communications Biology] Scientists provide distinct insight into how FOXA1 forkhead DNA-binding domain (FKHD) mutations drive prostate cancer progression and highlight potential therapeutic targets in tumors.

[Molecular Aspects of Medicine] The authors summarize the key molecular drivers of prostate cancer resistance and evaluates emerging invasive biomarkers with potential clinical utility.

[Oncogene] Scientists discuss the role of glycans in fundamental mechanisms controlling prostate cancer growth, metastasis, and immune evasion.

[Austrian Academy of Siences] The European Research Council (ERC) has awarded its most prestigious grants to Christoph Bock, Irene Forstner-Müller, and Jürgen Knoblich - a triple success for the Austrian Academy of Sciences (OeAW).

[Nature Microbiology] Investigators developed a human cerebral organoid model to investigate the host and viral determinants of Ebola virus central nervous system persistence.

[Developmental Cell] Scientists reported a multilevel branching lung organoid model generated from primary tip epithelial cells using a robust, chemically defined protocol.

[BMC Medicine] The authors established a standardized allogeneic 3D co-culture platform integrating patient-derived peritoneal metastatic gastric cancer organoids with pooled peripheral blood mononuclear cells from healthy donors.

[ACS Applied Materials & Interfaces] Researchers develop a tumor microenvironment-responsive nanoplatform that selectively disrupts colorectal cancer organoids through synergistic membrane damage, targeted drug release, and reactive oxygen species-mediated cell death.

[Cell Reports Methods] Investigators reported a multilevel branching lung organoid model generated from primary tip epithelial cells using a robust, chemically defined protocol.

[Cell Reports Methods] Scientists show that a simple 3D-printed stirred bioreactor improves retinal organoid yield and quality by maintaining physiological oxygen levels during differentiation.