Justin.choi

Pulmonary Cell News

EGFR Exon 20 Insertion Mutations in Advanced Non-Small-Cell Lung Cancer: Current Status and Perspectives

[Biomarker Research] The authors systematically review the recent clinical research of and treatments used for epidermal growth factor receptor ex20ins mutations, summarize the latest data on emerging therapies, and discuss future prospects and treatments.

Pulmonary Cell News

Incidental Discovery of Interstitial Lung Disease: Diagnostic Approach, Surveillance and Perspectives

[European Respiratory Review] Scientists focus on some of the limits of the current approach, underlying the potential for progression to full-blown interstitial lung disease of some patients with interstitial lung abnormalities (ILA) and the numerous links between subpleural fibrotic ILA and idiopathic pulmonary fibrosis.

Pulmonary Cell News

Coherus and Junshi Biosciences Announce PD-1 Inhibitor Toripalimab Granted Orphan Drug Designation for Small Cell Lung Cancer in the United States

[Coherus BioSciences, Inc.] Coherus BioSciences, Inc. announced that the FDA has granted Orphan Drug Designation for toripalimab, a PD-1 inhibitor, for the treatment of small cell lung cancer.

Neural Cell News

SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection

[Frontiers in Molecular Neuroscience] Investigators tested the hypothesis that ZIKV-associated degeneration of neuronal processes was dependent on activation of Sterile alpha and armadillo motif-containing protein 1 (SARM1), an NADase that acted as a central executioner in a conserved axon degeneration pathway.

Organoid News

Human Pluripotent Stem Cell-Derived Kidney Organoids for Personalized Congenital and Idiopathic Nephrotic Syndrome Modeling

[Development] Next-generation podocytes in kidney organoids enabled personalized idiopathic nephrotic syndrome modeling as shown by activated slit diaphragm signaling and podocyte injury following protamine sulfate, puromycin aminonucleoside treatment and exposure to nephrotic syndrome plasma containing pathogenic permeability factors.

Organoid News

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.

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Asahi Kasei Announces Initiation of Phase I Clinical Trial for Novel Peptide Candidate Targeting Autoimmune Diseases

[Asahi Kasei] Asahi Kasei announced the initiation of a Phase I clinical trial for AK1940, a novel peptide-based investigational compound developed to address significant unmet medical needs in patients with autoimmune diseases.

FDA Accepts Application for Genentech’s Gazyva for the Treatment of the Most Common Form of Lupus

[Genentech] Genentech announced that the US FDA has accepted the company’s supplemental Biologics License Application for Gazyva® for the treatment of systemic lupus erythematosus.

Low Dose IL-2 Therapy Restores Regulatory T Cells in Patients with Systemic Lupus Erythematosus in a Dose-Dependent Manner: A Phase IIb Trial

[Nature Communications] In this multicenter, double-blind, Phase IIb trial, 152 patients with active systemic lupus erythematosus were randomized to receive subcutaneous interleukin 2 or placebo every other day for 12 weeks, then weekly for another 12 weeks. Low-dose-IL2 drove the expansion of Tregs and altered Treg/effector T cell ratios.

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Justin.choi

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