Justin.choi

[Biomarker Research] The authors systematically review the recent clinical research of and treatments used for epidermal growth factor receptor ex20ins mutations, summarize the latest data on emerging therapies, and discuss future prospects and treatments.

[European Respiratory Review] Scientists focus on some of the limits of the current approach, underlying the potential for progression to full-blown interstitial lung disease of some patients with interstitial lung abnormalities (ILA) and the numerous links between subpleural fibrotic ILA and idiopathic pulmonary fibrosis.

[Coherus BioSciences, Inc.] Coherus BioSciences, Inc. announced that the FDA has granted Orphan Drug Designation for toripalimab, a PD-1 inhibitor, for the treatment of small cell lung cancer.

[Frontiers in Molecular Neuroscience] Investigators tested the hypothesis that ZIKV-associated degeneration of neuronal processes was dependent on activation of Sterile alpha and armadillo motif-containing protein 1 (SARM1), an NADase that acted as a central executioner in a conserved axon degeneration pathway.

[Development] Next-generation podocytes in kidney organoids enabled personalized idiopathic nephrotic syndrome modeling as shown by activated slit diaphragm signaling and podocyte injury following protamine sulfate, puromycin aminonucleoside treatment and exposure to nephrotic syndrome plasma containing pathogenic permeability factors.

[Cancer Research] Investigators showed that the mitochondrial calcium uniporter promoted pancreatic ductal adenocarcinoma cell migration, invasion, metastasis, and metabolic stress resistance by activating the Keap1-Nrf2 antioxidant program.