SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection

Investigators tested the hypothesis that ZIKV-associated degeneration of neuronal processes was dependent on activation of Sterile alpha and armadillo motif-containing protein 1 (SARM1), an NADase that acted as a central executioner in a conserved axon degeneration pathway.