Cholesterol Synthases Suppress Metastasis and Stemness through PDIA4/ACLY or SYVN1/SCD1 Axis in Advanced Colorectal Cancer

Scientists demonstrated that suppress of cholesterol synthases FDFT1 or SQLE enhances colorectal cancer metastasis and stemness through impairing ER stress and degrading PDIA4 or SYVN1 individually.