Justin.choi

Endothelial Cell News

Adverum Biotechnologies Doses First Patient in Cohort 4 of OPTIC Phase I Clinical Trial of ADVM-022 Intravitreal Gene Therapy for Wet AMD

[Adverum Biotechnologies, Inc.] Adverum Biotechnologies, Inc. announced that the first patient was dosed in Cohort 4 of the ongoing OPTIC Phase I clinical trial for ADVM-022 for the treatment of wet age-related macular degeneration (AMD).

Open Science Takes On the Coronavirus Pandemic

[Nature Technology Feature] When reports emerged in late 2019 of an outbreak of a new coronavirus centred in Wuhan, China, researchers at the virological-analysis website Nextstrain were ready. The open-source project tracks the spread of viruses through genetic variations in the sequences that scientists find.

Director of US Agency Key to Vaccine Development Leaves Role Suddenly Amid Coronavirus Pandemic

[STAT News] Rick Bright, one of the nation’s leading vaccine development experts and the director of the Biomedical Advanced Research and Development Authority, is no longer leading the organization.

Convergent Evolution of Monocyte Differentiation in Adult Skin Instructs Langerhans Cell Identity

[Science Immunology] Using ablation of embryo-derived Langerhans cells in the murine adult skin and tracking differentiation of incoming monocyte-derived replacements, researchers found intrinsic intraepidermal heterogeneity.

TCF-1 and TOX Regulate the Memory Formation of Intestinal Group 2 Innate Lymphoid Cells in Asthma

[Nature Communications] Based on house dust mite-induced mice asthma models and human samples, the authors applied flow cytometry, parabiosis, in vivo imaging, and adoptive transplantation to confirm the persistence, migration, and function of CD45+lineage–CD90.2+NK1.1–NKp46–ST2–KLRG1+IL-17RB+ memory-like ILC2s.

Tissue-Specific Inducible IL-33 Expression Elicits Features of Eosinophilic Esophagitis

[Journal of Allergy and Clinical Immunology] Scientists utilized a tetracycline-inducible system to express IL-33 in the esophagus by generating two transgenic mice.

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Justin.choi

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