Justin.choi

[eLife] By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, researchers showed that targeting signaling downstream of VEGFR2 pY949 limited vascular permeability in retinopathy induced by high oxygen or by laser-wounding.

[Scientific Reports] Gene Ontology (GO) analysis of far infrared radiation (FIR) up-regulated genes indicated that the pathways enriched in FIR-responsive endothelial colony forming cells were involved in cell viability, angiogenesis and transcription.

[Nature Communications] Scientists identified a critical role for NOTCH3 signaling in the differentiation of perivascular and sublining fibroblasts that expressed CD90. Using single-cell RNA sequencing and synovial tissue organoids, they found that NOTCH3 signaling drove both transcriptional and spatial gradients—emanating from vascular endothelial cells outwards—in fibroblasts.

[Cell Death & Disease] Investigators demonstrated that mixed-lineage kinase domain-like protein (MLKL) promoted vascular inflammation by regulating the expression of adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells.

[Cancer Biology & Therapy] Scientists explored the inherent mechanism of lncRNA OIP5-AS1 -AS1 in hepatocellular carcinoma (HCC). In the first place, qRT-PCR found that OIP5-AS1 and VEGFA expressions were significantly increased while miR-3163 was obviously reduced in HCC cells and tissues.

[Nature Communications] Using acute myeloid leukemia (AML) mouse models, scientists showed AML blasts released inflammatory mediators that upregulated endothelial niche E-selectin expression.