Vascular Permeability in Retinopathy Is Regulated by VEGFR2 Y949 Signaling to VE-Cadherin

By challenging mouse models representing different steps in VEGFA/VEGF receptor 2 (VEGFR2)-induced vascular permeability, researchers showed that targeting signaling downstream of VEGFR2 pY949 limited vascular permeability in retinopathy induced by high oxygen or by laser-wounding.