Filamentous and picoplanktonic cyanobacteria extracts were analyzed for their pigment profile, phenolic content, antioxidant potential, cytotoxicity against keratinocytes, fibroblasts, endothelial cells and capacity to inhibit hyaluronidase.
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Morone, J., Lopes, G., Preto, M., Vasconcelos, V., & Martins, R. (2020). Exploitation of Filamentous and Picoplanktonic Cyanobacteria for Cosmetic Applications: Potential to Improve Skin Structure and Preserve Dermal Matrix Components. Marine Drugs, 18(9), 486. https://doi.org/10.3390/md18090486 Cite
Tuning the traction and intercellular forces using different topographic geometries of symmetric and asymmetric ring-shape patterns regulated the vascular asymmetric morphogenesis in vitro.
Investigators showed that a subpopulation of angiogenic endothelial cells is induced in the brain in patients with Alzheimer’s disease. These angiogenic endothelial cells exhibited increased expression of angiogenic growth factors and their receptors and antigen-presentation machinery.
[Proceedings of the National Academy of Sciences of the United States of America]
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Investigators demonstrated that immunoglobulin and proline-rich receptor-1 (IGPR-1) was activated by autophagy-inducing stimuli, such as amino acid starvation, nutrient deprivation, rapamycin and lipopolysaccharide.
[Journal of Biological Chemistry]
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Researchers demonstrated that shear stress‐induced sensitization is brief and can be impaired when exposing aortic endothelial cells to low and proatherogenic levels of shear stress.
[Journal of Cellular Physiology]
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Blood outgrowth endothelial cells from idiopathic pulmonary artery hypertension patients were used to determine the impact of HIF2α-inhibition on endothelial function.
[European Respiratory Journal]
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Macias, D., Moore, S., Crosby, A., Southwood, M., Du, X., Tan, H., Xie, S., Vassallo, A., Wood, A. J., Wallace, E. M., & Cowburn, A. S. (2020). Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for Pulmonary Arterial Hypertension. European Respiratory Journal. https://doi.org/10.1183/13993003.02061-2019 Cite
The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
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Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., Erdal, S., Teo, H. M., Khalilnezhad, A., Chakarov, S., Lim, T. K. H., Fui, A. C. Y., Chieh, A. K. W., Chung, C. P., Bonney, G. K., … DasGupta, R. (2020). Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.08.040 Cite
Endothelial calmodulin, a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration.
[Journal of Experimental Medicine]
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Dalal, P. J., Sullivan, D. P., Weber, E. W., Sacks, D. B., Gunzer, M., Grumbach, I. M., Heller Brown, J., & Muller, W. A. (2021). Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Journal of Experimental Medicine, 218(1). https://doi.org/10.1084/jem.20192378 Cite
Ready-made microvessels promoted a sixfold increase in human induced pluripotent stem cell–derived cardiomyocyte (hiPSC-CM) survival and superior functional recovery when compared to hiPSC-CMs transplanted alone or cotransplanted with a suspension of dissociated endothelial cells in infarcted rat hearts.
[Science Translational Medicine]
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Sun, X., Wu, J., Qiang, B., Romagnuolo, R., Gagliardi, M., Keller, G., Laflamme, M. A., Li, R., & Nunes, S. S. (2020). Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats. Science Translational Medicine, 12(562). https://doi.org/10.1126/scitranslmed.aax2992 Cite
Researchers found that the nitric oxide synthase (NOS)-like nanoplatform (NanoNOS) greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease]