Exploitation of Filamentous and Picoplanktonic Cyanobacteria for Cosmetic Applications: Potential to Improve Skin Structure and Preserve Dermal Matrix Components

Filamentous and picoplanktonic cyanobacteria extracts were analyzed for their pigment profile, phenolic content, antioxidant potential, cytotoxicity against keratinocytes, fibroblasts, endothelial cells and capacity to inhibit hyaluronidase.
[Marine Drugs]
Morone, J., Lopes, G., Preto, M., Vasconcelos, V., & Martins, R. (2020). Exploitation of Filamentous and Picoplanktonic Cyanobacteria for Cosmetic Applications: Potential to Improve Skin Structure and Preserve Dermal Matrix Components. Marine Drugs, 18(9), 486. https://doi.org/10.3390/md18090486 Cite
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Mechanical Forces Regulate Asymmetric Vascular Cell Alignment

Tuning the traction and intercellular forces using different topographic geometries of symmetric and asymmetric ring-shape patterns regulated the vascular asymmetric morphogenesis in vitro.
[Biophysical Journal]
Cui, X., Tong, J., Yau, J., Bajpai, A., Yang, J., Peng, Y., Singh, M., Qian, W., Ma, X., & Chen, W. (2020). Mechanical Forces Regulate Asymmetric Vascular Cell Alignment. Biophysical Journal, 0(0). https://doi.org/10.1016/j.bpj.2020.09.020 Cite
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Single-Nucleus Transcriptome Analysis Reveals Dysregulation of Angiogenic Endothelial Cells and Neuroprotective Glia in Alzheimer’s Disease

Investigators showed that a subpopulation of angiogenic endothelial cells is induced in the brain in patients with Alzheimer’s disease. These angiogenic endothelial cells exhibited increased expression of angiogenic growth factors and their receptors and antigen-presentation machinery.
[Proceedings of the National Academy of Sciences of the United States of America]
Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020). Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2008762117 Cite
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Cell Adhesion Molecule IGPR-1 Activates AMPK Connecting Cell Adhesion to Autophagy

Investigators demonstrated that immunoglobulin and proline-rich receptor-1 (IGPR-1) was activated by autophagy-inducing stimuli, such as amino acid starvation, nutrient deprivation, rapamycin and lipopolysaccharide.
[Journal of Biological Chemistry]
Amraei, R., Alwani, T., Ho, R. X.-Y., Aryan, Z., Wang, S., & Rahimi, N. (2020). Cell adhesion molecule IGPR-1 activates AMPK connecting cell adhesion to autophagy. Journal of Biological Chemistry, jbc.RA120.014790. https://doi.org/10.1074/jbc.RA120.014790 Cite
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Analyzing the Shear-Induced Sensitization of Mechanosensitive Ion Channel Piezo-1 in Human Aortic Endothelial Cells

Researchers demonstrated that shear stress‐induced sensitization is brief and can be impaired when exposing aortic endothelial cells to low and proatherogenic levels of shear stress.
[Journal of Cellular Physiology]
Lai, A., Chen, Y. C., Cox, C. D., Jaworowski, A., Peter, K., & Baratchi, S. (n.d.). Analyzing the shear-induced sensitization of mechanosensitive ion channel Piezo-1 in human aortic endothelial cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30056 Cite
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Targeting HIF2α-ARNT Hetero-Dimerisation as a Novel Therapeutic Strategy for Pulmonary Arterial Hypertension

Blood outgrowth endothelial cells from idiopathic pulmonary artery hypertension patients were used to determine the impact of HIF2α-inhibition on endothelial function.
[European Respiratory Journal]
Macias, D., Moore, S., Crosby, A., Southwood, M., Du, X., Tan, H., Xie, S., Vassallo, A., Wood, A. J., Wallace, E. M., & Cowburn, A. S. (2020). Targeting HIF2α-ARNT hetero-dimerisation as a novel therapeutic strategy for Pulmonary Arterial Hypertension. European Respiratory Journal. https://doi.org/10.1183/13993003.02061-2019 Cite
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Onco-Fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

The hepatocellular carcinoma ecosystem displayed features reminiscent of fetal development, including re-emergence of fetal-associated endothelial cells and fetal-like tumor-associated macrophages.
[Cell]
Sharma, A., Seow, J. J. W., Dutertre, C.-A., Pai, R., Blériot, C., Mishra, A., Wong, R. M. M., Singh, G. S. N., Sudhagar, S., Khalilnezhad, S., Erdal, S., Teo, H. M., Khalilnezhad, A., Chakarov, S., Lim, T. K. H., Fui, A. C. Y., Chieh, A. K. W., Chung, C. P., Bonney, G. K., … DasGupta, R. (2020). Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.08.040 Cite
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Spatiotemporal Restriction of Endothelial Cell Calcium Signaling Is Required during Leukocyte Transmigration

Endothelial calmodulin, a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for leukocyte transendothelial migration.
[Journal of Experimental Medicine]
Dalal, P. J., Sullivan, D. P., Weber, E. W., Sacks, D. B., Gunzer, M., Grumbach, I. M., Heller Brown, J., & Muller, W. A. (2021). Spatiotemporal restriction of endothelial cell calcium signaling is required during leukocyte transmigration. Journal of Experimental Medicine, 218(1). https://doi.org/10.1084/jem.20192378 Cite
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Transplanted Microvessels Improve Pluripotent Stem Cell–Derived Cardiomyocyte Engraftment and Cardiac Function after Infarction in Rats

Ready-made microvessels promoted a sixfold increase in human induced pluripotent stem cell–derived cardiomyocyte (hiPSC-CM) survival and superior functional recovery when compared to hiPSC-CMs transplanted alone or cotransplanted with a suspension of dissociated endothelial cells in infarcted rat hearts.
[Science Translational Medicine]
Sun, X., Wu, J., Qiang, B., Romagnuolo, R., Gagliardi, M., Keller, G., Laflamme, M. A., Li, R., & Nunes, S. S. (2020). Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats. Science Translational Medicine, 12(562). https://doi.org/10.1126/scitranslmed.aax2992 Cite
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Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury

Researchers found that the nitric oxide synthase (NOS)-like nanoplatform (NanoNOS) greatly suppressed injury-driven monocyte-endothelial cell adhesion, suggesting NanoNOS treatment could help prevent cardiovascular diseases.
[ACS Nano]
Li, H., Yan, J., Meng, D., Cai, R., Gao, X., Ji, Y., Wang, L., Chen, C., & Wu, X. (2020). Gold Nanorod-Based Nanoplatform Catalyzes Constant NO Generation and Protects from Cardiovascular Injury. ACS Nano. https://doi.org/10.1021/acsnano.0c03629 Cite
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NLRP3 Inflammasome in Endothelial Dysfunction

The authors provide a comprehensive perspective on the pivotal role of NLR-family pyrin domain-containing protein 3 (NLRP3) inflammasome activation in aggravating oxidative stress and endothelial dysfunction and the possible underlying mechanisms.
[Cell Death & Disease]
Bai, B., Yang, Y., Wang, Q., Li, M., Tian, C., Liu, Y., Aung, L. H. H., Li, P., Yu, T., & Chu, X. (2020). NLRP3 inflammasome in endothelial dysfunction. Cell Death & Disease, 11(9), 1–18. https://doi.org/10.1038/s41419-020-02985-x Cite
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