Fibroblast CEBPD/SDF4 Axis in Response to Chemotherapy-Induced Angiogenesis through CXCR4

The authors found that cisplatin and 5-fluorouracil could induce fibroblast differentiation toward myofibroblasts via CCAAT/enhancer-binding protein delta and consequently promote proliferation, migration, and in vitro tube formation of vascular endothelial cells and angiogenesis in vivo.
[Cell Death & Discovery]
Chi, J.-Y., Hsiao, Y.-W., Liu, H.-L., Fan, X.-J., Wan, X.-B., Liu, T.-L., Hung, S.-J., Chen, Y.-T., Liang, H.-Y., & Wang, J.-M. (2021). Fibroblast CEBPD/SDF4 axis in response to chemotherapy-induced angiogenesis through CXCR4. Cell Death Discovery, 7(1), 1–16. https://doi.org/10.1038/s41420-021-00478-0 Cite
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Endothelial Angiogenic Activity and Adipose Angiogenesis Is Controlled by Extracellular Matrix Protein TGFBI

Researchers demonstrated that transforming growth factor-beta induced suppressed angiogenesis stimulated by adipocyte-conditioned medium, both in vitro and in vivo.
[Scientific Reports]
Lee, S. G., Kim, J. S., Kim, H.-J., Schlaepfer, D. D., Kim, I.-S., & Nam, J.-O. (2021). Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI. Scientific Reports, 11(1), 9644. https://doi.org/10.1038/s41598-021-88959-1 Cite
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MiR-206 Promotes Extracellular Matrix Accumulation and Relieves Infantile Hemangioma through Targeted Inhibition of DNMT3A

Researchers found that miR-206 could promote ECM accumulation through targeted inhibition of DNA Methyltransferase 3A (DNMT3A), inhibiting the malignant development of hemangioma endothelial cells and relieving infantile hemangioma.
[Cell Cycle]
MiR-206 promotes extracellular matrix accumulation and relieves infantile hemangioma through targeted inhibition of DNMT3A: Cell Cycle: Vol 0, No 0. (n.d.). Retrieved May 6, 2021, from https://www.tandfonline.com/doi/abs/10.1080/15384101.2021.1919820?journalCode=kccy20 Cite
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A Novel Strategy for Isolation of Mice Bone Marrow Endothelial Cells (BMECs)

Researchers outline a simple new technique of isolating mouse BMEC primary culture and a suitable method to evaluate the function and dysregulation of BMEC in in vitro studies using mouse models.
[Stem Cell Research & Therapy]
Smith, A. O., Adzraku, S. Y., Ju, W., Qiao, J., Xu, K., & Zeng, L. (2021). A novel strategy for isolation of mice bone marrow endothelial cells (BMECs). Stem Cell Research & Therapy, 12(1), 267. https://doi.org/10.1186/s13287-021-02352-3 Cite
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iPSC–Endothelial Cell Phenotypic Drug Screening and In Silico Analyses Identify Tyrphostin-AG1296 for Pulmonary Arterial Hypertension

Induced pluripotent stem cell-derived endothelial cells generated from six patients with pulmonary arterial hypertension were exposed to 4500 compounds and assayed for improved cell survival after serum withdrawal using a chemiluminescent caspase assay.
[Science Translational Medicine]
Gu, M., Donato, M., Guo, M., Wary, N., Miao, Y., Mao, S., Saito, T., Otsuki, S., Wang, L., Harper, R. L., Sa, S., Khatri, P., & Rabinovitch, M. (2021). iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension. Science Translational Medicine, 13(592). https://doi.org/10.1126/scitranslmed.aba6480 Cite
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Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
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A 3D iPSC-Differentiation Model Identifies Interleukin-3 as a Regulator of Early Human Hematopoietic Specification

Researchers used induced pluripotent stem cell technology and established a 3D, organoid-like differentiation system maintaining the structural cellular integrity to evaluate the effect of cytokines on embryonic hematopoietic development.
[Haematologica]
Ackermann, M., Haake, K., Kempf, H., Kaschutnig, P., Weiss, A.-C., Nguyen, A. H. H., Abeln, M., Merkert, S., Kühnel, M. P., Hartmann, D., Jonigk, D., Thum, T., Kispert, A., Milsom, M. D., & Lachmann, N. (2021). A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification. Haematologica, 106(5), 1354–1367. https://doi.org/10.3324/haematol.2019.228064 Cite
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Human Acellular Amniotic Membrane Incorporating Exosomes from Adipose-Derived Mesenchymal Stem Cells Promotes Diabetic Wound Healing

ADSC-derived exosomes enhanced the proliferation and migration of human dermal fibroblasts and promoted proliferation and tube formation of human umbilical vein endothelial cells in vitro.
[Stem Cell Research & Therapy]
Xiao, S., Xiao, C., Miao, Y., Wang, J., Chen, R., Fan, Z., & Hu, Z. (2021). Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing. Stem Cell Research & Therapy, 12(1), 255. https://doi.org/10.1186/s13287-021-02333-6 Cite
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Baicalein Alleviates Osteoarthritis by Protecting Subchondral Bone, Inhibiting Angiogenesis and Synovial Proliferation

Scientists found that intra‐articular injection of baicalein ameliorated subchondral bone remodelling. Baicalein impaired angiogenesis of endothelial cells and inhibited proliferation of synovial cells.
[Journal of Cellular and Molecular Medicine]
Li, B., Chen, K., Qian, N., Huang, P., Hu, F., Ding, T., Xu, X., Zhou, Q., Chen, B., Deng, L., Ye, T., & Guo, L. (n.d.). Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16538 Cite
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Transcription Factor FOXP2 Is a Flow-Induced Regulator of Collecting Lymphatic Vessels

Through transcriptional analysis of murine dermal lymphatic endothelial cells, scientists identified Foxp2, a member of the FOXP family of transcription factors implicated in speech development, as a collecting vessel signature gene.
[EMBO Journal]
Hernández Vásquez, M. N., Ulvmar, M. H., González-Loyola, A., Kritikos, I., Sun, Y., He, L., Halin, C., Petrova, T. V., & Mäkinen, T. (2021). Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels. The EMBO Journal, n/a(n/a), e107192. https://doi.org/10.15252/embj.2020107192 Cite
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Endothelial IGF-1 Receptor Mediates Crosstalk with the Gut Wall to Regulate Microbiota in Obesity

Scientists used gene‐modified mice with endothelial cell‐specific overexpression of human IGF‐1R and their wild‐type littermates.
[EMBO Reports]
Haywood, N. J., Luk, C., Bridge, K. I., Drozd, M., Makava, N., Skromna, A., Maccannell, A., Ozber, C. H., Warmke, N., Wilkinson, C. G., Watt, N. T., Koch-Paszkowski, J., Teh, I., Boyle, J. H., Smart, S., Schneider, J. E., Yuldasheva, N. Y., Roberts, L. D., Beech, D. J., … Kearney, M. T. (2021). Endothelial IGF-1 receptor mediates crosstalk with the gut wall to regulate microbiota in obesity. EMBO Reports, n/a(n/a), e50767. https://doi.org/10.15252/embr.202050767 Cite
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