Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy]
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Fan, X., He, S., Song, H., Yin, W., Zhang, J., Peng, Z., Yang, K., Zhai, X., Zhao, L., Gong, H., Ping, Y., Jiao, X., Zhang, S., Yan, C., Wang, H., Li, R.-K., & Xie, J. (2021). Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Research & Therapy, 12(1), 344. https://doi.org/10.1186/s13287-021-02423-5 Cite
Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
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Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
Scientists utilized a β3-endonexin mutant carrying a defective nuclear localization sequence to disrupt its nuclear localization and evaluated its ability to promote HUVEC proliferation and formation of tube-like vascular structures.
[Biochemical and Biophysical Research Communications]
Researchers used targeted next-generation sequencing or digital droplet polymerase chain reaction to screen for somatic PIK3CA mutations on DNA extracted from resected lesional tissue or lymphatic endothelial cells isolated from lesions.
[Orphanet Journal of Rare Disease]
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Brouillard, P., Schlögel, M. J., Homayun Sepehr, N., Helaers, R., Queisser, A., Fastré, E., Boutry, S., Schmitz, S., Clapuyt, P., Hammer, F., Dompmartin, A., Weitz-Tuoretmaa, A., Laranne, J., Pasquesoone, L., Vilain, C., Boon, L. M., & Vikkula, M. (2021). Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations. Orphanet Journal of Rare Diseases, 16(1), 267. https://doi.org/10.1186/s13023-021-01898-y Cite
The authors showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.
[European Respiratory Journal]
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Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard (2D) cell culture dishes or encapsulated in other hydrogels.
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The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology]
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Scientists developed F4L5.13, a tetravalent antibody designed to induce FZD4 and LRP5 proximity in such a way as to trigger βcatenin signaling. Treatment of cultured endothelial cells with F4L5.13 rescued permeability induced by VEGF in part by promoting surface expression of junction proteins.
[EMBO Molecular Medicine]
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Chidiac, R., Abedin, Md., Macleod, G., Yang, A., Thibeault, P. E., Blazer, L. L., Adams, J. J., Zhang, L., Roehrich, H., Jo, H.-N., Seshagiri, S., Sidhu, S. S., Junge, H. J., & Angers, S. (2021). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Molecular Medicine, n/a(n/a), e13977. https://doi.org/10.15252/emmm.202113977 Cite
The authors explored the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in Osteoarthritis.
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Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.
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Reserachers investigated the effects of hyperbaric oxygen treatment (HBOT) on solid tumors, such as lung cancer. Non-small cell human lung carcinoma A549-cell-transferred severe combined immunodeficiency mice were selected as an in vivo model to detect the potential mechanism of HBOT in lung tumors.
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Chen, S.-Y., Tsuneyama, K., Yen, M.-H., Lee, J.-T., Chen, J.-L., & Huang, S.-M. (2021). Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer. Scientific Reports, 11(1), 12033. https://doi.org/10.1038/s41598-021-91454-2 Cite