Human Endometrium-Derived Stem Cell Improves Cardiac Function after Myocardial Ischemic Injury by Enhancing Angiogenesis and Myocardial Metabolism

Investigators investigated whether human endometrium-derived stem cells could be used for cardiac repair after ischemic injury and their possible underlying mechanisms.
[Current Stem Cell Research & Therapy]
Fan, X., He, S., Song, H., Yin, W., Zhang, J., Peng, Z., Yang, K., Zhai, X., Zhao, L., Gong, H., Ping, Y., Jiao, X., Zhang, S., Yan, C., Wang, H., Li, R.-K., & Xie, J. (2021). Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism. Stem Cell Research & Therapy, 12(1), 344. https://doi.org/10.1186/s13287-021-02423-5 Cite
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Fungal Brain Infection Modeled in a Human-Neurovascular-Unit-on-a-Chip with a Functional Blood-Brain Barrier

Scientists showed that the neurotropism of Cryptococcus neoformans and its ability to penetrate the blood-brain barrier (BBB) could be modeled by the co-culture of human neural stem cells, brain microvascular endothelial cells and brain vascular pericytes in a human-neurovascular-unit-on-a-chip maintained by a stepwise gravity-driven unidirectional flow and recapitulating the structural and functional features of the BBB.
[Nature Biomedical Engineering]
Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., Bahn, Y.-S., & Cho, S.-W. (2021). Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier. Nature Biomedical Engineering, 1–17. https://doi.org/10.1038/s41551-021-00743-8 Cite
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β3-Endonexin Interacts with Ninein in Vascular Endothelial Cells to Promote Angiogenesis

Scientists utilized a β3-endonexin mutant carrying a defective nuclear localization sequence to disrupt its nuclear localization and evaluated its ability to promote HUVEC proliferation and formation of tube-like vascular structures.
[Biochemical and Biophysical Research Communications]
Cao, Z., Ge, S., Xu, Z., & Ma, Y.-Q. (2021). β3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis. Biochemical and Biophysical Research Communications, 566, 75–79. https://doi.org/10.1016/j.bbrc.2021.06.008 Cite
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Non-Hotspot PIK3CA Mutations Are More Frequent in CLOVES than in Common or Combined Lymphatic Malformations

Researchers used targeted next-generation sequencing or digital droplet polymerase chain reaction to screen for somatic PIK3CA mutations on DNA extracted from resected lesional tissue or lymphatic endothelial cells isolated from lesions.
[Orphanet Journal of Rare Disease]
Brouillard, P., Schlögel, M. J., Homayun Sepehr, N., Helaers, R., Queisser, A., Fastré, E., Boutry, S., Schmitz, S., Clapuyt, P., Hammer, F., Dompmartin, A., Weitz-Tuoretmaa, A., Laranne, J., Pasquesoone, L., Vilain, C., Boon, L. M., & Vikkula, M. (2021). Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations. Orphanet Journal of Rare Diseases, 16(1), 267. https://doi.org/10.1186/s13023-021-01898-y Cite
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Mesenchymal Stromal (Stem) Cell (MSC) Therapy Modulates miR-193b-5p Expression to Attenuate Sepsis-Induced Acute Lung Injury

The authors showed that treatment with MSCs decreased expression of host-derived miR-193b-5p and increased expression of its target gene, the tight junctional protein occludin, in lungs from septic mice.
[European Respiratory Journal]
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Bio-Instructive Hydrogel Expands the Paracrine Potency of Mesenchymal Stem Cells

Scientists introduced a customizable collagen I-hyaluronic acid (COL-HA)-based hydrogel platform for the encapsulation of MSCs. Cells encapsulated within COL-HA showed a significant expansion of their secretory profile compared to MSCs cultured in standard (2D) cell culture dishes or encapsulated in other hydrogels.
[Biofabrication]
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Review: Circadian Clocks and Rhythms in the Vascular Tree

The authors survey recent observations that are shedding more light on the nature of the interaction between circadian rhythms and the vascular system with implications for blood vessel disease.
[Current Opinion in Pharmacology]
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A Norrin/Wnt Surrogate Antibody Stimulates Endothelial Cell Barrier Function and Rescues Retinopathy

Scientists developed F4L5.13, a tetravalent antibody designed to induce FZD4 and LRP5 proximity in such a way as to trigger βcatenin signaling. Treatment of cultured endothelial cells with F4L5.13 rescued permeability induced by VEGF in part by promoting surface expression of junction proteins.
[EMBO Molecular Medicine]
Chidiac, R., Abedin, Md., Macleod, G., Yang, A., Thibeault, P. E., Blazer, L. L., Adams, J. J., Zhang, L., Roehrich, H., Jo, H.-N., Seshagiri, S., Sidhu, S. S., Junge, H. J., & Angers, S. (2021). A Norrin/Wnt surrogate antibody stimulates endothelial cell barrier function and rescues retinopathy. EMBO Molecular Medicine, n/a(n/a), e13977. https://doi.org/10.15252/emmm.202113977 Cite
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Cartilage Tissue miR-214-3p Regulates the TrkB/ShcB Pathway Paracrine VEGF to Promote Endothelial Cell Migration and Angiogenesis

The authors explored the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in Osteoarthritis.
[Bone]
Xiao, P., Zhu, X., Sun, J., Zhang, Y., Qiu, W., Li, J., & Wu, X. (2021). Cartilage tissue miR-214-3p regulates the TrkB/ShcB pathway paracrine VEGF to promote endothelial cell migration and angiogenesis. Bone, 116034. https://doi.org/10.1016/j.bone.2021.116034 Cite
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YAP/TAZ Suppress Drug Penetration into Hepatocellular Carcinoma via Stromal Activation

Multi-cellular hepatocellular carcinoma (HCC) organoid models were established which contained various types of stromal cells, such as hepatic stellate cells, fibroblasts, and endothelial cells together with HCC cells.
[Hepatology]
Cho, K., Ro, S. W., Lee, H. W., Moon, H., Han, S., Kim, H. R., Ahn, S. H., Park, J. Y., & Kim, D. Y. (n.d.). YAP/TAZ suppress drug penetration into hepatocellular carcinoma via stromal activation. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.32000 Cite
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Hyperbaric Oxygen Suppressed Tumor Progression through the Improvement of Tumor Hypoxia and Induction of Tumor Apoptosis in A549-Cell-Transferred Lung Cancer

Reserachers investigated the effects of hyperbaric oxygen treatment (HBOT) on solid tumors, such as lung cancer. Non-small cell human lung carcinoma A549-cell-transferred severe combined immunodeficiency mice were selected as an in vivo model to detect the potential mechanism of HBOT in lung tumors.
[Scientific Reports]
Chen, S.-Y., Tsuneyama, K., Yen, M.-H., Lee, J.-T., Chen, J.-L., & Huang, S.-M. (2021). Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancer. Scientific Reports, 11(1), 12033. https://doi.org/10.1038/s41598-021-91454-2 Cite
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