Justin.choi

Mammary Cell News

Diosgenin Derivatives Developed from Pd(ii) Catalysed Dehydrogenative Coupling Exert an Effect on Breast Cancer Cells by Abrogating Their Growth and Facilitating Apoptosis via Regulating...

[Dalton Transactions] Based on the pharmacological importance of diosgenin, the obtained derivatives were exposed to study their effect on breast cancer cells where they significantly reduced the growth of cancer cells and left non-malignant breast epithelial cells unaffected.

Mammary Cell News

Clinically Relevant CHK1 Inhibitors Abrogate Wild-Type and Y537S Mutant ERα Expression and Proliferation in Luminal Primary and Metastatic Breast Cancer Cells

[Journal of Experimental & Clinical Cancer Research] The authors evaluated if kinases could be new targets for the treatment of luminal primary and metastatic breast cancers.

Mammary Cell News

Nrf2 and NF-κB/NLRP3 Inflammasome Pathways Are Involved in Prototheca bovis Infections of Mouse Mammary Gland Tissue and Mammary Epithelial Cells

[Free Radical Biology and Medicine] Investigators characterized how Prototheca bovis induced inflammatory responses in mouse mammary gland tissue and mammary epithelial cells.

Mammary Cell News

Modified Bovine Milk Exosomes for Doxorubicin Delivery to Triple-Negative Breast Cancer Cells

[ACS Applied Bio Materials] Scientists described the use of two chemical modifications, incorporating a neuropilin receptor agonist peptide and a hypoxia-responsive lipid for targeting and release of an encapsulated drug from bovine milk exosomes toTNBC cells.

Mammary Cell News

Dinaciclib Inhibits the Stemness of Two Subtypes of Human Breast Cancer Cells by Targeting the FoxM1 and Hedgehog Signaling Pathway

[Oncology Reports] Investigators aimed to examine the stemness‑inhibitory effects of dinaciclib in MCF‑7 and HCC‑1806 breast cancer cells.

Mammary Cell News

Breast Cancer in the Era of Integrating “Omics” Approaches

[Oncogenesis] The authors investigated the correlation between different “omics” datasets and to define the new important key pathway and upstream regulators in breast cancer.

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Asahi Kasei Announces Initiation of Phase I Clinical Trial for Novel Peptide Candidate Targeting Autoimmune Diseases

[Asahi Kasei] Asahi Kasei announced the initiation of a Phase I clinical trial for AK1940, a novel peptide-based investigational compound developed to address significant unmet medical needs in patients with autoimmune diseases.

FDA Accepts Application for Genentech’s Gazyva for the Treatment of the Most Common Form of Lupus

[Genentech] Genentech announced that the US FDA has accepted the company’s supplemental Biologics License Application for Gazyva® for the treatment of systemic lupus erythematosus.

Low Dose IL-2 Therapy Restores Regulatory T Cells in Patients with Systemic Lupus Erythematosus in a Dose-Dependent Manner: A Phase IIb Trial

[Nature Communications] In this multicenter, double-blind, Phase IIb trial, 152 patients with active systemic lupus erythematosus were randomized to receive subcutaneous interleukin 2 or placebo every other day for 12 weeks, then weekly for another 12 weeks. Low-dose-IL2 drove the expansion of Tregs and altered Treg/effector T cell ratios.

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Justin.choi

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