Researchers Find Pancreatic Cancer Stem Cells
Researchers have discovered a small population of stem cells in pancreatic cancer that appear to drive tumor growth, opening the door for a potential new approach for treating this particularly deadly disease.
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Critical Stem Cell Survival Factors Found
As researchers attempt to take advantage of the potential of adult stem cells in regenerative medicine, understanding the mechanisms that delimit lifespan and longevity of stem cells will be critically important. Researchers have now identified a family of proteins that contributes to the survival and regenerative potential of blood-forming stem cells.
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Master at Regeneration: Learning Why the Liver Thrives
Researchers have now found one clue that may tell them why the liver is a master of regeneration.
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Study Finds Genes that Predict Transplant Rejection
Canadian researchers believe they have come up with a way to predict whether transplants from specific bone marrow donors are likely to trigger rejection – an advance that could help doctors weed out so-called "dangerous donors” and cut back on immune suppressant drugs for some transplant recipients.
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Pluristem Announces Evidence That PLX-I Cells Are Immune Privileged
Being immune privileged, the PLX-1 cells carry significant positive implications in the development of Company products for a variety of degenerative, malignant and immune diseases.
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Gene Therapy Tackles Severe Burns
Severe burns are not only painful, they also put patients at risk of serious infection. Now researchers are using gene therapy to rev up the wound healing process in skin cells, hoping to fight potentially lethal infections.
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Gene Therapy for AIDS
Specialists of the V.A. Engelgardt Institute of Molecular Biology, Russian Academy of Sciences, and the "Vector" Main Research Center of Virology and Biotechnology created and tested three genetic structures capable of suppressing reproduction of human immunodeficiency virus (HIV-1) in human cells.
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Scientists Develop Gene-Activating Technique
U.S. scientists have developed a new laboratory technique that uses ribonucleic acid (RNA), a tiny chemical cousin of DNA, to switch on genes. This approach may help in the development of treatments for diseases in which prompting genes into activity could benefit patients.
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B-Cell Chronic Lymphocytic Leukemia Clinical Trial Initiated with Argos Therapeutics’ AGS-005 Personalized Immunotherapy
Argos Therapeutics today announced that dosing has been initiated in a Phase 1/2 clinical trial to test the activity and safety of AGS-005 in B-cell chronic lymphocytic leukemia (CLL).
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MultiGene Vascular Systems Begins Clinical Trials of Blood Vessel Therapy
MultiGene Vascular Systems Ltd. has begun Phase I human clinical trials of its MultiGeneGraf cell therapy for growing blood vessels.
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Introgen’s INGN 225 Molecular Cancer Vaccine Demonstrates Promising Results in Phase 2 Trial
Approximately half of patients with advanced small cell lung cancer responded to Introgen Therapeutics, Inc.’s INGN 225 molecular cancer vaccine in combination with subsequent chemotherapy.
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Opexa Achieves Midpoint in Patient Admissions in Phase IIb Trial of Tovaxin(TM) for Multiple Sclerosis
Opexa Therapeutics, Inc.has announced that it has admitted the first 75 patients in its 150-patient Phase IIb clinical trial of Tovaxinâ„¢ in multiple sclerosis. Enrollment is expected to be completed by mid-2007. There are currently 34 trial sites in the U.S., all of which are actively recruiting patients.
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Aastrom Receives Orphan Drug Designation from FDA for Dilated Cardiomyopathy
Aastrom Biosciences, Inc., a company focused on the use of autologous cells for regenerative medicine, has announced that the Company’s proprietary Tissue Repair Cells (TRCs) received an Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) for use in the treatment of dilated cardiomyopathy (DCM), a severe chronic disease of the heart.
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Stem Cells The Key Element For Future Transplantology
To achieve successful results of transplantation and treatment of such significant diseases as Parkinson’s disease, Alzheimer’s disease, leukemia, diabetes, stroke, muscular dystrophy, hepatic and renal failure etc., optimum methods have to be developed to obtain stem cells and their cultivation. Such a problem is successfully solved by scientists from Kazakhstan.
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Stem Cell Refugees
In the U.S., doctors have only injected small groups of people with stem cells from fetuses or cord blood as part of clinical trials. Chinese doctors insist the concerns are overblown.
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ABSTRACT, REVIEWS AND SPECIAL REPORTS
Identification of Pancreatic Cancer Stem Cells
Using a xenograft model in which primary human pancreatic adenocarcinomas were grown in immunocompromised mice, the researchers identified a highly tumorigenic subpopulation of pancreatic cancer cells expressing the cell surface markers CD44, CD24, and epithelial-specific antigen (ESA).
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