| TOP STORY | Stem Cells Regenerate Human Lens after Cataract Surgery, Restoring Vision Researchers have developed a new, regenerative medicine approach to remove congenital cataracts in infants, permitting remaining stem cells to regrow functional lenses. The treatment, which has been tested in animals and in a small, human clinical trial, produced much fewer surgical complications than the current standard-of-care and resulted in regenerated lenses with superior visual function in all 12 of the pediatric cataract patients who received the new surgery. [Press release from the University of California, San Diego discussing online prepublication in Nature] Press Release | Abstract | |
| REVIEWS | Cell Therapy in Chronic Liver Disease Mesenchymal stem cells are promising candidates for cell transplantation, as they have been shown to reduce liver fibrosis and support endogenous regeneration. Adipose tissue-derived stem cells are also being tested in this setting, because of their ready availability. [Curr Opin Gastroenterol] Abstract Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research fields. |
| SCIENCE NEWS | Benitec’s Hepatitis B Therapy Reduces HBV DNA by 98.5% In Vivo Benitec Biopharma Limited announced that BB-HB-331, a DNA-directed RNA interference therapy targeting the hepatitis B virus (HBV), demonstrates robust and durable suppression of HBV in vivo following a single administration. [Press release from the Benitec Biopharma Limited discussing research to be presented at the HEP DART 2015, Wailea] Press Release TiGenix Announces Positive 52-Week Phase III Results of Cx601 in Complex Perianal Fistulas in Crohn’s Disease Patients TiGenix NV announced that a single injection of Cx601 was statistically superior to placebo in achieving combined remission at week 52 in the Phase III ADMIRE-CD trial in Crohn’s disease patients with complex perianal fistulas with inadequate response to previous therapies, including anti-TNFs. [TiGenix NV (GlobeNewswire, Inc.)] Press Release Atreca Announces Presentation of Preclinical Data for Cancer Immunotherapy Program Atreca, Inc. announced positive preclinical findings generated using the company’s Immune Repertoire Capture™ technology. Immune Repertoire Capture™ technology generated the sequences of native antibodies from the active immune response of an individual with Stage 4 lung adenocarcinoma who had experienced long-term non-progression of disease. [Press release from the Atreca, Inc. discussing research to be presented at the Keystone Symposia Conference “Antibodies as Drugs”, Whistler] Press Release Combination of Lapatinib and Trastuzumab Shrinks HER2 Positive Breast Cancer Significantly in 11 Days after Diagnosis Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs lapatinib and trastuzumab before surgery and chemotherapy, saw their tumors shrink significantly or even disappear, according to results from a clinical trial. [Press release from The University of Manchester discussing research presented at 10th European Breast Cancer Conference (EBCC-10), Amsterdam] Press Release Biothera Pharmaceuticals to Present Its Phase II Cancer Immunotherapy Data Biothera Pharmaceuticals Inc. presented data on its Phase II cancer immunotherapy Imprime PGG, the company’s first-in-class, systemically administered beta glucan pathogen associated molecular patterning molecule. [Press release from Biothera Pharmaceuticals Inc. discussing research presented at the Molecular Medicine Tri-Conference 2016, San Francisco] Press Release From our sponsor: Culturing hematopoietic stem and progenitor cells? Download the technical bulletin. |
| POLICY | Accusations of Errors and Deception Fly in CRISPR Patent Fight Adversaries in the legal battle over the rights to the CRISPR gene-editing technology are preparing to fire their initial shots. In two documents filed with the U.S. Patent Trial and Appeal Board, lawyers for the Regents of the University of California and the Broad Institute, offered hints at how they will lay claim to the breakthrough technology and its financial spoils. [ScienceInsider] Editorial Statisticians Issue Warning over Misuse of P Values Misuse of the P value is contributing to the number of research findings that cannot be reproduced, the American Statistical Association warns in a statement. The group has taken the unusual step of issuing principles to guide use of the P value, which it says cannot determine whether a hypothesis is true or whether results are important. [Nature News] Editorial |
| BUSINESS | Baylor College of Medicine, Baylor Scott & White Health Announce Collaboration on Biomedical Research Baylor College of Medicine and Baylor Scott & White Health have entered into an agreement to expand biomedical research in North and Central Texas. [Baylor Scott & White Health] Press Release Temple University Hospital Offering New Trial Using Donor Stem Cells to Treat Heart Failure Temple University Hospital is participating in a nationwide, Phase III clinical trial investigating stem cells as a treatment for patients with chronic heart failure due to left ventricular systolic dysfunction. The trial, dubbed DREAM-HF, is a double-blind, randomized, placebo controlled trial investigating whether donor stem cells which are injected into the damaged portion of the heart can restore heart muscle function. [Temple University] Press Release Data Safety and Monitoring Board Recommends Celldex’s Phase III Study of RINTEGA® (Rindopepimut) in Newly Diagnosed Glioblastoma Be Discontinued as It Is Unlikely to Meet Primary Overall Survival Endpoint in Patients with Minimal Residual Disease Celldex Therapeutics, Inc. announced that the independent Data Safety and Monitoring Board has determined, based on a preplanned interim analysis, that continuation of the Phase III ACT IV study of RINTEGA® in patients with newly diagnosed EGFRvIII-positive glioblastoma will not reach statistical significance for overall survival in patients with minimal residual disease, the primary endpoint of the study, as both the RINTEGA arm and the control arm are performing on par with each other. [Celldex Therapeutics, Inc.] Press Release Vericel Announces Positive Top-Line Results from Phase IIb ixCELL-DCM Clinical Trial of Ixmyelocel-T in Patients with Heart Failure Due to Ischemic Dilated Cardiomyopathy Vericel Corporation announced top-line results from the company’s Phase IIb ixCELL-DCM clinical trial of ixmyelocel-T in patients with advanced heart failure due to ischemic dilated cardiomyopathy (DCM). [Vericel Corporation] Press Release Data and Safety Monitoring Board Recommends Advance of Current DC Vaccine Clinical Trial in AML into Phase II Medigene AG announced the successful recruitment of the planned patients for Phase I of its current clinical trial of dendritic cell (DC) vaccines in acute myeloid leukemia (AML). [Medigene AG] Press Release Alliance for Cancer Gene Therapy Announces Three New Grant Awardees for Cancer Research Alliance for Cancer Gene Therapy (ACGT) announced the recipients of its 2016 ACGT Young Investigator Grants. These grants are awarded to help the researchers build upon earlier research and take them to the next level in cancer treatment, setting the stage for possible clinical trials. [Alliance for Cancer Gene Therapy (EurekAlert)] Press Release Spark Therapeutics Announces Acquisition of Genable Technologies Spark Therapeutics announced that it has acquired Genable Technologies, a private gene therapy innovator with which Spark has collaborated since 2014 in the development of Genable’s therapeutic program targeting one of the most prevalent forms of inherited retinal disease. [Spark Therapeutics, Inc.] Press Release Peregrine Pharmaceuticals Announces Formal Commissioning of New, State-of-the-Art Commercial Manufacturing Facility Peregrine Pharmaceuticals, Inc. announced that its new state-of-the-art commercial biomanufacturing suite in Tustin, California, has been formally commissioned. As part of the commissioning process, all relevant regulatory agencies have been notified and cGMP production is currently underway. [Peregrine Pharmaceuticals, Inc.] Press Release Celsion Corporation Announces Launch of the OPTIMA Study in China Celsion Corporation announced the launch of the OPTIMA Study in China. The OPTIMA Study is the company’s global pivotal, double-blind, placebo-controlled trial, evaluating ThermoDox®, Celsion’s proprietary heat-activated liposomal encapsulation of doxorubicin, in combination with radiofrequency ablation standardized to 45 minutes (sRFA) versus sRFA alone to treat newly diagnosed patients with hepatocellular carcinoma. [Celsion Corporation] Press Release |
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