Endothelial Cell News 1.19 July 25, 2016 | |
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TOP STORYUsing endothelium-specific Jagged1 knockdown mice, researchers found that blocking Jagged1 prevented diabetes-induced microvasculopathy (DMV) even under diabetic conditions. Furthermore, in the inducible endothelium-specific Jagged1 knockdown mice, blocking Jagged1 even at four weeks after the establishment of DMV could reverse it, leading to normalization of retinal vasculature. [Circulation] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Glycolytic Regulation of Cell Rearrangement in Angiogenesis Scientists report that computational simulations, validated by experimentation, predict that glycolytic production of ATP drives endothelial cell rearrangement by promoting filopodia formation and reducing intercellular adhesion. [Nat Commun] Full Article Investigators produced genome-edited mesenchymal stem cells (MSCs) that secreted hepatocyte growth factor (HGF) upon drug-specific induction. The inducible HGF expression cassette was integrated into a safe harbor site in an MSC chromosome using the TALEN system, resulting in the production of TetOn-HGF/human umbilical cord blood-derived-MSCs. [Mol Ther] Abstract Endothelial von Willebrand Factor knockdown prevented angiotensin II-induced endothelin-1 upregulation through attenuation of nicotinamide adenine dinucleotide phosphate oxidase-mediated superoxide anion production. [Sci Rep] Full Article Conditioned media from endothelial cells (EC-CM) subjected to simulated microgravity increased osteoblast proliferation and decreased their differentiation compared to unit gravity EC-CM. [Sci Rep] Full Article Researchers demonstrated that stimulation of D1 dopamine receptors present in dermal fibroblasts restores vascular endothelial growth factor A production by these cells, resulting in adequate angiogenesis and subsequent healing of cutaneous wounds in both type 1 and type 2 diabetic mice. [Am J Pathol] Abstract 3-Methylcholanthrene/Aryl-Hydrocarbon Receptor–Mediated Hypertension through eNOS Inactivation The authors indicated that 3-methylcholanthrene (3-MC) modified heat shock protein 90, caveolin-1, dynein, and endothelial nitric oxide synthase (eNOS) mRNA and protein expression through the aryl hydrocarbon receptor (AhR)/RhoA-dependent mechanism in mouse cerebral vascular endothelial cells and that 3-MC reduced eNOS phosphorylation through the AhR/RhoA-mediated inactivation of Akt1. [J Cell Physiol] Abstract From Glioblastoma to Endothelial Cells through Extracellular Vesicles: Messages for Angiogenesis The authors assessed in detail the extracellular vesicles phenomenon in the human glioblastoma cell line U251 and evaluated extracellular vesicles ability to promote the processes required to achieve the formation of new blood vessels in human brain microvascular endothelial cells, highlighting that they stimulate proliferation, motility, and tube formation in a dose-response manner. [Tumor Biol] Abstract Toll-Like Receptor 4 Promotes Angiogenesis in Pancreatic Cancer via PI3K/AKT Signaling Scientists aimed to investigate the role of Toll-like receptor 4 in the angiogenesis of pancreatic cancer and the underlying molecular mechanisms. [Exp Cell Res] Abstract Researchers evaluated the effects of testosterone and voluntary exercise on vascular endothelial growth factor-A (VEGF-A), stromal cell-derived factor 1a (SDF-1a) and myocardial capillary density in heart of rats with diabetes. [Can J Diabetes] Abstract | |
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REVIEWSLiver Sinusoidal Endothelial Cells: Physiology and Role in Liver Diseases The authors present a detailed analysis of the technical aspects relevant for liver sinusoidal endothelial cell (LSEC) analysis including the markers these cells express, the available cell lines and the transgenic mouse models. Finally, this review provides an overview of the strategies available for a specific targeting of LSECs. [J Hepatol] Abstract KSHV-Mediated Angiogenesis in Tumor Progression The authors summarize the current knowledge on regulating Kaposi’s sarcoma-associated herpesvirus (KSHV)-mediated angiogenesis by integrating the findings reported thus far on the roles of host and viral genes in oncogenesis, recent developments in cell-culture/animal-model systems, and various anti-angiogenic therapies for treating KSHV-related lymphoproliferative disorders. [Viruses] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSExelixis, Inc. and Ipsen announced that the Committee for Medicinal Products for Human Use (CHMP), the scientific committee of the European Medicines Agency, provided a positive opinion for Cabometyx™ 20, 40, 60mg for the treatment of advanced renal cell carcinoma (RCC) in adults following prior vascular endothelial growth factor (VEGF)-targeted therapy and recommended it for marketing authorization. [Exelixis, Inc.] Press Release ViaCyte Awarded New CIRM Grant to Develop PEC-Direct for High-Risk Type 1 Diabetes ViaCyte, Inc. announced that the California Institute for Regenerative Medicine (CIRM) approved a grant of $3.9 million to support pre-clinical development of ViaCyte’s PEC-Direct cell therapy product candidate which is being developed for a subset of type 1 diabetes patients. [ViaCyte, Inc.] Press Release | |
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POLICY NEWSScientific Literature: Information Overload Recent bibliometrics show that the number of published scientific papers has climbed by 8–9% each year over the past several decades. In the biomedical field alone, more than 1 million papers pour into the PubMed database each year — about two papers per minute. For researchers who are already overwhelmed by bench and field work, grant-writing, publishing and other time-eaters, trying to navigate the growing deluge of data has become a second job. [Nature Careers] Editorial Exactly 1 month after Britain’s momentous decision to leave the European Union, around 4500 scientists and friends of science will assemble in Manchester, UK, for the opening of the EuroScience Open Forum, Europe’s largest interdisciplinary research conference. [Science] Editorial
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EVENTSNEW 7th International Conference on Stem Cells and Cancer (ICSCC-2016): Proliferation, Differentiation and Apoptosis Visit our events page to see a complete list of events in the endothelial cell community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Molecular and Cell Biology (University Hospital of Munster) Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School) Postdoctoral Position – Vascular Biology (Boston Children’s Hospital) Postdoctoral Fellow – Vascular Cell Signaling (LSU Health Science Center) Postdoctoral Positions – Endothelial Cells (Instituto de Medicina Molecular) Faculty Position – Liver Regeneration (University of Poitiers) Postdoctoral Fellow – Immunometabolism (Dalhousie University) Postdoctoral Position – Endothelial Cells (KULeuven) PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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