Endothelial Cell News 1.23 August 29, 2016 | |
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TOP STORYAntiangiogenic and Tumor Inhibitory Effects of Downregulating Tumor Endothelial FABP4 The authors investigated the role of fatty acid binding protein 4 (FABP4) in endothelial fatty acid metabolism and tumor angiogenesis. They analyzed the effect of transient FABP4 knockdown in human umbilical vein endothelial cells on fatty acid metabolism, viability and angiogenesis. [Oncogene] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Inhibition of MicroRNA-495 Enhances Therapeutic Angiogenesis of Human Induced Pluripotent Stem Cells Researchers developed an endothelial cell generation approach by inhibiting microRNA-495 in human induced pluripotent stem cells and assessed the angiogenic potential for myocardial infarction treatment. [Stem Cells] Abstract Factors Regulating Capillary Remodeling in a Reversible Model of Inflammatory Corneal Angiogenesis Researchers used a novel reversible model of inflammatory angiogenesis in the rat cornea to investigate endogenous factors rapidly invoked to remodel, normalize and regress microcapillaries as part of the natural response to regain corneal avascularity. [Sci Rep] Full Article Investigators used synthetic Toll-like receptor (TLR)9 agonists, cytosine-phosphate-guanosine oligodeoxynucleotides (CpG-ODN), to investigate the role of TLR9 in vascular pathophysiology and identify potential therapeutic translation. They demonstrated that CpG-ODN stimulates inflammation yet inhibits angiogenesis. [Sci Rep] Full Article The authors focused on microRNA (miR)-23a and miR-23b, and investigated the functional effects of these miRs on junctions. While miR-23a and 23b only differ by 1 nucleotide outside the seed region and thus are predicted to have the same targets, they function differently with miR-23a inhibiting permeability and miR-23b inhibiting angiogenesis. [Mol Ther Nucleic Acids] Full Article CD151 Mediates Netrin-1-Induced Angiogenesis through the Src-FAK-Paxillin Pathway Scientists examined the role of netrin-1 in angiogenesis and explored the underlying mechanisms. The effect of netrin-1 on brain tissues and endothelial cells was examined by immunohistochemistry and western blotting in a middle cerebral artery occlusion model and in human umbilical vein endothelial cells. [J Cell Mol Med] Full Article The authors aimed to determine if cardioprotective effect of metformin is mediated by increasing circulating endothelial progenitor cells, pro-angiogenic cells and decreasing circulating endothelial cells count whilst maintaining unchanged glycemic control. [Cardiovasc Diabetol] Full Article Panaxnotoginseng (PNS) promotes lymphangiogenesis of thoracic duct in zebrafish with or without vascular endothelial growth factors receptor 3 Kinase inhibitor pre-impairment. PNS promotes proliferation, migration and tube formation of lymphatic endothelial cells. [J Ethnopharmacol] Abstract Researchers showed efficient differentiation of murine induced pluripotent stem (iPS) cells into endothelial cells (ECs) with stable CD34+/Tie-2+/Sca-1+/CD45− phenotype and proven functionality. iPS-derived ECs were positive for phospho-eNOS and von Willebrand factor, and responded to shear stress with up-regulation of KLF-2, KDR, HO-1, and increased nitric oxide and VEGF production. [Vascul Pharmacol] Abstract Scientists investigated the role of ADAM9 in hematogenous and lymphatic tumor cell dissemination assisting the development of new therapeutic tools. The role of ADAM9 in the interaction of breast tumor cells and endothelial cells was studied through RNA silencing. [Biochimie] Abstract | |
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REVIEWSAutophagy in Vascular Endothelial Cells The author provides a summary of the current knowledge on the regulatory factors, signaling mechanisms, and functional outcomes of autophagy in endothelial cells. [Clin Exp Pharmacol Physiol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSBiothera Pharmaceuticals, Inc. announced a collaboration with Merck to expand the companies’ ongoing clinical program evaluating KEYTRUDA®, Merck’s anti-PD-1 inhibitor, in combination with Biothera’s Imprime PGG, a Pathogen Associated Molecular Patterning molecule, or PAMP. [Biothera Pharmaceuticals, Inc.] Press Release Xenetic Biosciences, Inc. announced that an Investigational New Drug application for the company’s product candidate, Virexxa®, has been allowed to proceed by the U.S. Food and Drug Administration (FDA). [Xenetic Biosciences, Inc.] Press Release | |
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POLICY NEWSSouth African Academics Warn of Universities on the Brink More than 1,200 South African academics are warning that the country’s university system is at a tipping point as a result of chronic underfunding. [Nature] Editorial Special: Obama’s Science Legacy The United States will elect a new president in November 2016. Nature is tracking the battle between Republican Donald Trump and Democrat Hillary Clinton — and analyzing how the election outcome could affect science. [Nature] Editorial New Leader of NIH’s Research Watchdog Faces Staff Revolt The Office of Research Integrity (ORI) in Rockville, Maryland, which guards against misconduct in biomedical research, usually attracts attention with its findings, not its internal workings. But two years ago, its director, David Wright, quit in a public huff, complaining that ORI was hobbled by a dysfunctional federal bureaucracy. Now, his successor is encountering her own rough waters, Science has learned. [ScienceInsider] Editorial
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EVENTSNEW 2016 National Cancer Research Institute (NCRI) Cancer Conference Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Associate – Innate Immunity and Inflammation (University of Illinois) Postdoctoral Research Assistant – Bone and Vascular Biology (University of Oxford) PhD Thesis – In Vitro Models of the Blood-Saliva Barrier (Austrian Institute of Technology GmbH) Postdoctoral Position – Vascular Inflammation Contributes and Atherosclerosis (University of Hawaii) Postdoctoral Position – Molecular and Cell Biology (University Hospital of Munster) Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School) Postdoctoral Position – Vascular Biology (Boston Children’s Hospital) Postdoctoral Position – Endothelial Cells (KULeuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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