Endothelial Cell News 1.34 November 28, 2016 | |
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TOP STORYMicroRNA Regulation of Endothelial TREX1 Reprograms the Tumor Microenvironment Researchers report a unique mechanism by which ectopic microRNA-103 can manipulate tumor-associated endothelial cells to enhance tumor cell death. Using gain-and-loss of function approaches, they show that microRNA-103 exacerbates DNA damage and inhibits angiogenesis in vitro and in vivo. [Nat Commun] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)The Robo4 Cytoplasmic Domain Is Dispensable for Vascular Permeability and Neovascularization Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4−/− mice that develop hyperpermeability, but how Robo4 signals remained unclear. Scientists showed that Robo4 deletion enhances permeability and revascularization in oxygen-induced retinopathy and accelerates cutaneous wound healing. [Nat Commun] Full Article Researchers identified lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) as a marker of yolk sac endothelium and definitive hematopoietic stem and progenitor cells. [Cell Rep] Full Article | Graphical Abstract The authors showed that the artery-derived ligand semaphorin 3G and the endothelial cell receptor PlexinD1 play a role in lymphatic vascular patterning. [Cell Rep] Full Article | Graphical Abstract Scientists provided a thorough, unbiased analysis of the two groups of endothelial cell colony-forming units (EC-CFUs) from patients with malignant breast disease and healthy controls. This was achieved using transcriptomic analysis and validated in vitro to distinguish the detailed molecular fingerprints of the two EC-CFUs. [Sci Rep] Full Article Investigators observed that the natural product 2,4,5-trihydroxybenzaldehyde (TDB) could effectively inhibit vascular cell apoptosis following oxygen-glucose deprivation/reperfusion by maintaining mitochondrial membrane potential and suppressing activation of the mitochondria-dependent caspase-9/3 apoptosis pathway. [Sci Rep] Full Article Researchers investigated the effects of the JAK2/STAT3/SOSC1 signaling pathway on the secretion function of vascular endothelial cells in a rat model of pregnancy-induced hypertension. [Cell Physiol Biochem] Full Article Hypertension is one of the most important cardiovascular risk factors and results in macrophage infiltration of blood vessels. However, how macrophages coordinate inflammatory responses with endothelial cells (ECs) remains unclear. In this study, the authors investigated whether exosomes upregulate the expression of inflammatory factors in ECs under hypertensive conditions. [Hypertens Res] Abstract Researchers investigated the therapeutic effects of iptakalim and natakalim against isoproterenol-induced chronic heart failure in rats, and demonstrated a new therapeutic approach to the treatment of chronic heart failure through activation of the SUR2B/Kir6.1 channel in endothelial cells. [Acta Pharmacol Sin] Abstract Investigators demonstrated the effects and possible mechanisms of B-myb involved in the context of cellular senescence. The results indicate that B-myb expression is decreased not only in the aortas of aged mice but also in replicative senescent endothelial cells, even in stress-senescent endothelial cells induced by bleomycin. [Cell Prolif] Abstract | |
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REVIEWSThe Role of GATA2 in Lethal Prostate Cancer Aggressiveness Scientists provide insight into the key function that endothelial transcription factor GATA-2 (GATA2), a transcription factor classically linked with hematopoiesis, exerts as a mediator of prostate cancer progression in both an androgen receptor (AR)-dependent and AR-independent manner and through the early to late stages of the disease. [Nat Rev Urol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSMorgridge–UW Project Investigates Tissue-Engineered Arteries for Transplant The prospect of creating artery “banks” available for cardiovascular surgery, bypassing the need to harvest vessels from the patient, could transform treatment of many common heart and vascular ailments. But it’s a big leap from concept to reality. The Morgridge Institute for Research and the University of Wisconsin–Madison will address both the engineering and biomedical hurdles in this process through a five year, $8 million project funded by the National Heart, Lung, and Blood Institute. [University of Wisconsin-Madison] Press Release OrbusNeich Introduces a New Generation COMBO plus Dual Therapy Stent for Active Healing OrbusNeich has announced the launch of its latest generation Dual Therapy Stent, the COMBO Plus. The COMBO Plus has a unique anti-CD34 antibody biological coating that offers an advanced approach to active vessel healing combined with improved deliverability for patients with complex coronary artery disease. Following implantation, the biological coating on the outer surface of the COMBO Plus immediately captures endothelial progenitor cells and initiates the formation of an endothelial layer. [OrbusNeich] Press Release | |
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POLICY NEWSCongress Poised to Pass Sweeping Biomedical Innovation Bill Congress is poised to approve a massive piece of legislation that would provide the National Institutes of Health with $4.8 billion over the next decade for a set of research initiatives, including brain and cancer research and efforts to develop so-called precision medicine treatments that are tailored to an individual’s genetic makeup. [ScienceInsider] Editorial Spanish Military Flies Lab Animals to Canary Islands after Airlines Refuse to Take Them on Board Twenty-nine transgenic mice that two Spanish airlines had refused to transport hitched a ride to the Canary Islands on a military plane Friday and are now at their final destination, the University of La Laguna on Tenerife in Spain. The mice, bred in the United States, had been stranded in Madrid for two months because Iberia and Air Europa have stopped shipping laboratory animals. [ScienceInsider] Editorial
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EVENTSNEW American Association for Cancer Research (AACR) Annual Meeting 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Endothelial Interactions in Vascular Disease (University of Pittsburgh) NEW Postdoctoral Position – Intersectional Genetics (VIB) Postdoctoral Associate – Neuroscience (University of Pittsburgh) Postdoctoral Fellow – Vascular Cell Signaling (Louisiana State University Health Sciences Center) Postdoctoral Position – Endothelial Heterogeneity (KULeuven) Postdoctoral Fellow – Molecular Cardiology (Cleveland Clinic) Senior Scientific Researcher – Molecular Oncology (Genentech) Cell Biologist – Pulmonary Vascular Signaling and Endothelial Cell Biology (University of Maryland) Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Endothelial Cell News Volume 1.34 | Nov 28 2016