Endothelial Cell News 2.08 March 13, 2017 | |
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TOP STORYMechanisms Regulating Angiogenesis Underlie Seasonal Control of Pituitary Function The authors showed that melatonin time-dependently acts on its receptors in the pars tuberalis (PT) to alter splicing of vascular endothelial growth factor (VEGF). Outside the breeding season, angiogenic VEGF-A stimulates vessel growth in the infundibulum, aiding vascular communication among the PT, pars distalis, and brain. [Proc Natl Acad Sci USA] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the spatio-temporal dynamics of cardiovascular progenitor populations. They showed that expression of the cardiac transcription factor Nkx2.5 marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. [Elife] Abstract | Full Article (Download) Researchers modified small-caliber electrospun poly(ε-caprolactone) (PCL) vascular grafts with a fusion protein vascular endothelial growth factor (VEGF)-class I hydrophobin (HGFI) which consists of the class I hydrophobin and VEGF, via hydrophobic interactions. Blood compatibility tests demonstrated lower level of fibrinogen absorption, platelet activation and aggregation on the VEGF-HGFI modified PCL mats than that on the bare PCL mats. [ACS Appl Mater Interfaces] Abstract Investigators found that amphoterin-induced gene and open reading frame 2 (amigo2) expression in human cancers was higher in liver metastatic lesions than in primary lesions. Amigo2 regulated tumor cell adhesion to liver endothelial cells and formation of liver metastases. [Sci Rep] Full Article Human Corneal Endothelial Cell Cultivation from Old Donor Corneas with Forced Attachment Researchers used hyaluronic acid (HA) in combination with Rho-kinase inhibitor (ROCK) Y-27632 for the cultivation of human corneal endothelial cells (HCEnCs) from older donor corneas. Four conditions including and excluding HA + ROCK and its effect on early attachment rates and proliferation was studied on forty-eight corneas. They observed that HCEnCs reach confluence within 10–15 days when cultured with HA + ROCK. [Sci Rep] Full Article Scientists found that long non-coding RNAs X-inactive-specific transcript (XIST) was upregulated in endothelial cells that were obtained in a blood–tumor barrier (BTB) model in vitro. XIST knockdown increased BTB permeability and inhibited glioma angiogenesis. [Oncogenesis] Full Article The authors investigated whether Qiliqiangxin (QL) could protect cardiac microvascular endothelial cells (CMECs) against anoxic injury and explored related signaling mechanisms. [J Cell Mol Med] Full Article Investigators showed that regulator of calcineurin 1 (RCAN1.4) has a role in the regulation of agonist-stimulated VEGFR-2 internalization and establishment of endothelial cell polarity. siRNA-mediated gene silencing revealed that RCAN1 played a vital role in regulating VEGF-mediated cytoskeletal reorganization and directed cell migration and sprouting angiogenesis. [Angiogenesis] Full Article Scientists showed that melatonin, 3-indolacetic acid, 5-hydroxytryptophol, and serotonin are proved to significantly inhibit vascular endothelial growth factor (VEGF)-induced VEGFR-2 activation in human umbilical vein endothelial cells and subsequent angiogenesis. 3-Indolacetic acid showed the highest inhibitory effect, followed by 5-hydroxytryptophol, melatonin, and serotonin. [Nutrients] Full Article GFAT1 Phosphorylation by AMPK Promotes VEGF-Induced Angiogenesis Researchers tested the hypothesis that AMP-activated protein kinase (AMPK) controls O-linked β-N-acetylglucosamine (O-GlcNAc) levels and function of endothelial cells via glutamine:fructose-6-phosphate amidotransferase 1 (GFAT1) phosphorylation using biochemical, pharmacological, genetic and in vitro angiogenesis approaches. Activation of AMPK in primary human endothelial cells by 5-aminoimidazole-4-carboxamide riboside or by vascular endothelial growth factor (VEGF) led to GFAT1 phosphorylation at serine 243. [Biochem J] Abstract | |
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REVIEWSThe Role of Notch Signaling in Ovarian Angiogenesis The authors review the literature on the expression pattern of Notch pathway components in the ovary and on the role of Notch signaling pathway on ovarian angiogenesis. [J Ovarian Res] Full Article Researchers discuss the influence of angiogenesis and inflammation pathways on vascular permeability in vestibular schwannomas and subependymal giant cell tumors at the phenotypic level as well as their possible genetic and molecular determinants. [Neurosurg Rev] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSChi-Med Presented Sulfatinib Neuroendocrine Tumors Phase Ib/II Results Hutchison China MediTech Limited (Chi-Med) presented data from the ongoing Phase Ib/II clinical trial of sulfatinib in patients with advanced neuroendocrine tumors. [Press release from Hutchison China MediTech Limited discussing research presented at the 14th Annual Conference of the European Neuroendocrine Tumor Society, Barcelona] Press Release | |
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INDUSTRY NEWSTyrogenex announced the completion of patient enrollment in the APEX study – a Phase II trial of X-82 for the oral treatment of wet age-related macular degeneration (AMD). The APEX study is a randomized, double-masked, placebo-controlled, dose-finding, non-inferiority study of X-82 plus as-needed intravitreal anti-VEGF compared to as-needed intravitreal anti-VEGF alone in patients with neovascular AMD. [Tyrogenex] Press Release Adrenomed AG announced the successful completion of a first-in-human study that demonstrated excellent safety and tolerability of Adrecizumab in healthy volunteers. The monoclonal Adrenomedullin-specific antibody Adrecizumab was developed to selectively support the beneficial effects of Adrenomedullin, an endogenous hormone that maintains endothelial integrity and prevents vascular leakage. The efficacy of Adrecizumab will be assessed in a first clinical proof-of-concept study (Phase-II) in patients with early septic shock. [Adrenomed AG] Press Release | |
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POLICY NEWSCanada’s New Genetic Privacy Law Is Causing Huge Headaches for Justin Trudeau A vote in Canada’s Parliament to approve a genetic privacy bill is creating a self-inflicted political headache for Prime Minister Justin Trudeau’s Liberal government—and could result in a relatively rare and unusual court case. [ScienceInsider] Editorial Physician with Drug-Industry Ties Is Trump’s FDA Pick President Donald Trump has nominated Scott Gottlieb — a conservative pundit, physician and venture capitalist — to head the US Food and Drug Administration (FDA). [Nature News] Editorial
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EVENTSNEW 6th China-Europe Symposium on Biomaterials in Regenerative Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Position – Retinal Cell Biology (University of California, Davis) NEW PhD Student – Cardiovascular Diseases (Maastricht University) Postdoctoral Fellowship – In Vitro Neural Systems (Karolinska Institute) Postdoctoral Research Positions – Tissue Microenvironment in Chronic Kidney Disease (Inserm) Postdoctoral Fellow – Stem Cell Biology (Northwestern University) PhD Position – Molecular Biology (Institute of Molecular Biology) Postdoctoral Fellow – Cardiopulmonary Molecular Biology (Hannover Medical School) Postdoctoral Fellowship – RNA Biology (Goethe University Frankfurt) Assistant/Associate Professor – Angiogenesis in Urology (Northwestern University) PhD Position – Genome Engineering (KU Leuven, Stem Cell Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Endothelial Cell News Volume 2.08 | Mar 13 2017