Endothelial Cell News 2.33 October 2, 2017 | |
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TOP STORYThe authors report a pro-survival approach based on VEGF-immobilized microparticles (MPs). VEGF-MPs prolonged VEGFR-2 and Akt phosphorylation in cord blood-derived late outgrowth endothelial progenitor cells. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Transcriptional Regulation of Endothelial Cell Behavior during Sprouting Angiogenesis Scientists characterized dynamic gene expression changes during postnatal development and identified critical angiogenic factors in mouse retinal endothelial cells. [Nat Commun] Full Article Systems Biology Analysis of Longitudinal Functional Response of Endothelial Cells to Shear Stress Investigators carried out a longitudinal time-series study to measure the transcriptome after the application of pulsatile shear and oscillatory shear. They performed systems analyses of transcriptional data of cultured human vascular endothelial cells to elucidate the dynamics of endothelial responses in several functional pathways such as cell cycle, oxidative stress, and inflammation. [Proc Natl Acad Sci USA] Abstract Atheroprotective high shear stress (SS) stimulated endothelial autophagic flux in human and murine arteries. Endothelial cells exposed to atheroprone low SS were characterized by inefficient autophagy as a result of mammalian target of rapamycin activation, AMPKα inhibition, and blockade of the autophagic flux. [Proc Natl Acad Sci USA] Abstract The complexity of 3D endothelial cell networks formed from human umbilical vein endothelial cells and normal human lung fibroblasts as a function of hydrogel properties and vascular endothelial growth factor presentation is presented. [Adv Healthc Mater] Abstract Scientists investigated how transthyretin affects the progression of neovascularization in diabetic retinopathy (DR). Natural and simulated DR media were used to culture human retinal microvascular endothelial cells. [Cell Physiol Biochem] Full Article Using transcriptome and proteome analysis, researchers identified distinctive late endothelial progenitor cell (LEPC) profiles and found that HIP was strongly expressed in LEPCs. [Sci Rep] Full Article Insulin-like growth factor-1 (IGF-1) treatment promoted the formation of vessel-like structures and the recruitment of adipose-derived stem cells in a three-dimensional collagen gel. [Cell Prolif] Abstract The authors showed that under hypoxia, the expression of bone morphogenetic protein 7 (BMP-7) was decreased both in vivo and in vitro. They also found that under normoxia, BMP-7 deficiency induced spontaneous endothelial-to-mesenchymal transition and cell migration. [J Cell Physiol] Abstract Investigators studied the effects of piperine on the uptake of plasma bound 3H-propranolol and 14C-warfarin by cultured bovine brain microvascular endothelial cells. Piperine increased the free fraction of both albumin and alpha-acid glycoprotein bound drugs in a concentration-dependent manner. [Phytother Res] Abstract | |
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REVIEWSVascular Stem/Progenitor Cells: Functions and Signaling Pathways Owing to the essential roles of blood vessels in human tissues and organs, understanding the functional properties and the underlying molecular basis of vascular stem/progenitor cells is of critical importance for both basic and translational research. [Cell Mol Life Sci] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSSYNERGYS Announces Phase I SBIR Grant Award from National Institutes of Health Synergys Biotherapeutics announced the receipt of a Phase I grant from the National Cancer Institute under auspices of the Small Business Innovation Research (SBIR) program of the National Institutes of Health. [Synergys Biotherapeutics (Business Wire, Inc.)] Press Release Eisai Inc. announced the FDA accepted for review a supplemental New Drug Application for lenvatinib for the potential use in the first-line treatment of patients with hepatocellular carcinoma. [Eisai Inc. (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSAfter Upheaval, Russian Academy of Sciences Gets New Leader After months of uncertainty, the Russian Academy of Sciences finally has a new leader. Russian President Vladimir Putin approved physicist Alexander Sergeyev as the academy’s president for the next five years. Sergeyev has vowed to secure more money for Russian science and create a fund, through a new tax on fossil fuel company profits, for upgrading the country’s antiquated research infrastructure. [ScienceInsider] Editorial Researchers Caught in Growing Rift over Catalan Independence Scientists in Catalonia are feeling the ripples of a severe crisis as the region’s bid for independence from Spain comes to a head. [ScienceInsider] Editorial French Government Proposes Big Science-Spending Boost French research funding is set for a heartening increase in the country’s first budget under President Emmanuel Macron, if draft 2018 plans are voted into law. [Nature News] Editorial
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EVENTSNEW International Vascular Biology Meeting (IVBM) 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postgraduate Position – Mechanobiology of Cell Fate in 3D, Multicellular Environment (KU Leuven) NEW Postdoctoral Position – Tumor Immunology and Cancer Immunotherapy (VIB) Postdoctoral Research Fellow – Cerebral Small Vessel Disease (University of Edinburgh) Postdoctoral Fellow – Tumor and Vascular Biology (Karolinska Institutet) Postdoctoral Fellow – Inflammation and Endothelial Cell Biology (University of Gothenburg) Postdoctoral Fellow – Vascular Cell Signaling (Louisiana State University Health Sciences Center) Postdoctoral Position – Biology of Blood Platelets (INSERM) Assistant Professor – Stem Cell and Regenerative Medicine (Harvard University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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