Endothelial Cell News 4.09 March 18, 2019 | |
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TOP STORYMechanistic studies demonstrated that Akirin2 induced angiogenesis by increasing the expression of VEGFA by activating the IL-6/STAT3 signaling pathway. Akirin2 promoted cell migratory and invasive potential by affecting the epithelial-mesenchymal transition process. [Cell Death Dis] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Transfection with miR-370 mimic (miR-370m) significantly inhibited the sprouting of human dermal microvascular endothelial cells (HDMECs) and HUVEC spheroids and mouse aortic rings, whereas miR-370 inhibitor promoted sprout formation. Additional in vitro assays demonstrated the pleiotropic inhibitory effects of miR-370m on HDMEC proliferation, migration, and tube formation. [FASEB J] Abstract Pro-Angiogenic Ginsenosides F1 and Rh1 Inhibit Vascular Leakage by Modulating NR4A1 Researchers systemically investigated the effects of ten different ginsenosides on HUVECs and identified that two PPT-type ginsenosides, F1 and Rh1 induced the migration and proliferation of endothelial cells. In addition, F1 and Rh1 significantly inhibited vascular leakage both in vitro and in vivo, which were induced by VEGF. [Sci Rep] Full Article Endothelial colony forming cells extracted from cord blood were used either fresh or frozen, at culture days <30, to investigate the intracellular presence of CD133 by flow cytometry and confocal analysis. Comparison with HUVEC and HAEC mature endothelial cells was carried out. [Stem Cell Rev] Abstract BDNF-Mediated Mitophagy Alleviates High-Glucose-Induced Brain Microvascular Endothelial Cell Injury High-glucose treatment caused cell dysfunction, as evaluated by oxidative stress and cell apoptosis, which could be alleviated by brain-derived neurotrophic factor (BDNF). In addition, BDNF preserved mitochondrial function as assessed by mitochondrial permeability transition pore opening, mitochondrial membrane potential, calcium content, and mitochondrial biogenesis markers. [Apoptosis] Abstract Investigators revealed that cooking oil fumes-derived PM2.5 exposure reduced HUVECs’ viability, increased the intracellular and mitochondrial ROS levels in cells, and up-regulated the levels of proteins and mRNA involved in the NLRP3 inflammasome signaling pathway. [Ecotoxicol Environ Saf] Abstract | Graphical Abstract Functionally, hepatocyte nuclear factor 4α (HNF4α) inhibited VEGF-mediated endothelial proliferation and migration, and blunted VEGF-stimulated in vitro angiogenesis, thus rendering endothelial cells unresponsive to established angiogenic VEGF stimulation. Mechanistically, HNF4α potentiated the endothelial VEGF resistance through the direct transcriptional repression of the FLK1 gene. [J Cell Biochem] Abstract Thrombosis was assessed both in vitro by measuring thrombin generation time (TGT) and tissue factor (TF) expression and in vivo by the measurement of the time to occlusion in carotid and the total thrombosis area in mesenteric arteries. TGT, TF, and VCAM1 expression were evaluated in human aortic endothelial cells. [PLoS One] Full Article Scientists demonstrated that vitamin D improved the viability, migration ability, and tube formation of angiotensin II (AngII)-pretreated endothelial progenitor cells (EPCs) and inhibited the apoptosis of EPCs induced by AngII. Vitamin D also reversed reactive oxygen species production, vascular inflammatory cytokine generation, and nuclear factor kappa-B activation in EPCs induced by AngII. [J Vasc Res] Abstract Evolocumab significantly increased HUVECs viability at 100 μg/mL. Significant enhancement in cell migration, and mean tubules length and size was observed at the concentrations of 10 and 100 μg/mL and also in mean number of junctions at the concentration of 100 μg/mL. Administration of evolocumab at the concentration of 10 μg/mL increased VEGF release into supernatants of HUVECs. [Can J Physiol Pharmacol] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSMechanosensing and Mechanoregulation of Endothelial Cell Functions The authors summarize the current understanding of endothelial cell (EC) mechanosensory mechanisms, modulation of EC responses to humoral factors by surrounding mechanical forces, and discuss recent findings of magnitude-specific regulation of EC functions by transcriptional, posttranscriptional and epigenetic mechanisms using -omics approaches. [Compr Physiol] Abstract Role of Endothelial NAD+ Deficiency in Age-Related Vascular Dysfunction The preventive and therapeutic potential of NAD+ intermediates as effective, clinically relevant interventions in older adults at risk for ischemic heart disease, vascular cognitive impairment and other common geriatric conditions and diseases that involve vascular pathologies is critically discussed. [Am J Physiol Heart Circ Physiol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSThéa and OliX Announce Collaboration to Develop RNAi Therapies for the Treatment of AMD OliX Pharmaceuticals, Inc. announced that it has signed a license and collaboration agreement with Théa Open Innovation, a sister company of Laboratoires Théa S.A.S, to develop and commercialize OLX301A. [OliX Pharmaceuticals, Inc.] Press Release Aerpio Pharmaceuticals Announces Results from TIME-2b Study of AKB-9778 in Diabetic Retinopathy Aerpio Pharmaceuticals, Inc. announced top-line results from the company’s TIME-2b study, a Phase IIb clinical trial designed to assess the efficacy and safety of Aerpio’s lead candidate, AKB-9778, for patients with moderate to severe non-proliferative diabetic retinopathy. [Aerpio Pharmaceuticals, Inc.] Press Release GlycoNet Awards $1.45 Million to Eight Projects Aimed at Improving the Health of Canadians The Canadian Glycomics Network (GlycoNet) awarded $1.45 million in grants to support eight research projects, to be carried out at eight universities or research centers across Canada. Funding was allocated in the last quarter of 2018. [Canadian Glycomics Network] Press Release | |
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POLICY NEWSAppeals Court Dismisses Charges of Institutional Racism at UK-Kenyan Research Partnership An appeals court in Kenya has dismissed charges of institutional racism at a UK-Kenyan research partnership. The Court of Appeal in Nairobi overturned a 2014 verdict by a lower court that found that six Kenyan academics working for the Kenya Medical Research Institute-Wellcome Trust Research Programme, had faced “systemic discrimination” in their careers. [ScienceInsider] Editorial Survey Highlights “Shocking” Gender Bias among PI Pay in UK Organizers of a survey of early-career scientists in the UK say they are shocked by the picture it paints of gender bias in British science. Women principal investigators (PIs) who have started their own lab in recent years are paid thousands of pounds a year less than men at the same stage of their career, the results show. [The Scientist] Editorial Norway Joins List of Countries Canceling Elsevier Contracts Norway has become the latest country to cancel its contracts with Elsevier following a dispute over access to research papers. In a statement published March 12, the Norwegian Directorate for ICT and Joint Services in Higher Education and Research, which represents a consortium of research institutions in the country, rejected Elsevier’s offer to lower some of its costs for Norwegian institutions because it didn’t go far enough to promote free access to published research. [The Scientist] Editorial
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EVENTSNEW World Congress on Cardiology and Cardiovascular Diseases Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Vascular Biology (Albert Einstein College of Medicine) Postdoctoral Research Assistant – Cancer & Vascular Biology (University of Oxford) Faculty Position – Bioengineering (University of Pittsburgh) Postdoctoral Position – Endothelial Cell Protection (University of Bern) Postdoctoral Position – Angiogenesis/Vascular Biology (Johns Hopkins University) Vascular Biologist – RNA Therapeutics (Guide Therapeutics) Postdoctoral Fellow – Vascular Biology (Stanford School of Medicine) Postdoctoral Fellow – Vascular Biology (University of Nevada, Reno) Tier 2 Canada Research Chair – Cardiovascular/Vascular Health (University of Ottawa) Faculty Position – Clinical & Experimental Therapeutics (Augusta University) Postdoctoral Position – Cardiovascular Research (University of Hawaii) Assistant/Associate Adjunct Professor – Cardiovascular Medicine (UC Davis) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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