Cancer Stem Cell News 6.47 November 29, 2017 | |
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TOP STORYInterplay between Notch1 and Notch3 Promotes EMT and Tumor Initiation in Squamous Cell Carcinoma The authors demonstrated that Notch1 activation and epithelial–mesenchymal transition (EMT) are coupled to promote squamous cell carcinoma tumor initiation in concert with transforming growth factor (TGF)-β present in the tumor microenvironment. TGFβ drove Notch1-mediated EMT to generate tumor initiating cells characterized by high CD44 expression. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)YAP1 and COX2 Coordinately Regulate Urothelial Cancer Stem-Like Cells Researchers report that the pro-inflammatory COX2/PGE2 pathway and the YAP1 growth regulatory pathway cooperated to recruit the stem cell factor SOX2 in expanding and sustaining the accumulation of urothelial CSC. [Cancer Res] Abstract Scientists demonstrated that eukaryotic initiation factor 5A2 (EIF5A2) might play a crucial role in CSC regulation and investigated its potential molecular mechanisms. [Stem Cells] Abstract The authors investigated the effect of miR-203 expression and bufalin treatment on glioma cell proliferation and stem cell-like phenotypes. Bufalin treatment inhibited cell proliferation, colony formation, and CSC phenotypes and increased cell apoptosis and expression of miR-203. [Cell Physiol Biochem] Full Article Aspirin attenuated colonosphere formation and decreased the ALDH1 positive cell population of colorectal cancer cells. Aspirin inhibited xenograft tumor growth and reduced tumor cells stemness in nude mice. [Cell Physiol Biochem] Full Article Scientists investigated biological function of SLC34A2 in regulating sphere formation and tumorigenicity of gastric cancer stem cell-like cells and its underlying mechanisms. Their findings testified that CD44+ cells, which were derived from fresh primary gastric cancer samples and cell lines displayed stem cell-like features. [Mol Carcinog] Abstract Notch Pathway Inhibition Targets Chemoresistant Insulinoma Cancer Stem Cells Researchers characterized and targeted insulinoma (INS) CSCs in order to develop novel targeted therapies. Highly invasive and tumorigenic human and canine INS CSC-like cells were successfully isolated. [Endocr Relat Cancer] Abstract Using a transcription factor pull-down assay with PIK3CA promoter, the authors identified NF-κB as a prime regulator, which escalates both TNFα and PIK3CA expression only in CSC enriched side-population, but not in non side-population in platinum resistant ovarian cancer cells upon cisplatin treatment. [J Exp Clin Cancer Res] Full Article A Distinct Endocytic Mechanism of Functionalized-Silica Nanoparticles in Breast Cancer Stem Cells Investigators demonstrated that the uptake of silica nanoparticles (SiNPs), particularly amino-functionalized SiNPs, in MCF-7 cells is strongly affected by the actin depolymerization, whereas breast cancer stem cells more strongly inhibit the amino-functionalized SiNP uptake after the scavenger receptor disruption. [Sci Rep] Full Article Scientists showed that under sphere-forming assay conditions, prostate cancer cells acquired CSC-like properties: promoted mitochondrial respiratory chain activity, expression of characteristic CSC markers and resistance to anticancer agents. [Oncogenesis] Full Article The Effects of PI3K-Mediated Signaling on Glioblastoma Cell Behavior Researchers used two distinct pharmacological inhibitors that block signaling at different points of the cascade, namely, GDC-0941, a direct inhibitor of the near apical PI3K, and Rapamycin, which blocks the side arm of the network that is regulated by mTOR complex 1. [Oncogenesis] Full Article | |
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REVIEWSThe stem cell markers octamer-binding transcription factor 4 (OCT4), sex-determining region Y-box 2 (SOX2), NANOG, Kruppel-like factor 4 (KLF4) and c-MYC are key factors in inducing pluripotency in somatic cells, and they have been used to detect cancer stem cell subpopulations in a range of cancer types. Recent literature has described the subcellular localization of these markers and their potential implications on cellular function. [J Clin Pathol] Abstract Visit our reviews page to see a complete list of reviews in the cancer stem cell research field. | |
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INDUSTRY NEWSRegen BioPharma, Inc. Begins In Vivo Assessment of Small Molecule Agonists to NR2F6 Nuclear Receptor Regen BioPharma Inc. initiated in vivo and ex vivo assessments to determine the effects of some of the company’s NR2F6 small molecule agonists in live rats and in tissues derived from humans and rats. The NR2F6 nuclear receptor has been identified as a potentially very important immune cell inhibitor and cancer stem cell differentiator. [Regen BioPharma Inc. (PR Newswire Association LLC)] Press Release Amphivena Therapeutics Inc. announced that it has received Orphan Drug Designation from the U.S. Food and Drug Administration for its lead compound AMV564 for the treatment of acute myeloid leukemia. [Amphivena Therapeutics Inc. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSChina to Roll Back Regulations for Traditional Medicine Despite Safety Concerns Support for traditional medicine in China goes right to the top. President Xi Jinping has called this type of medicine a “gem” of the country’s scientific heritage and promised to give alternative therapies and Western drugs equal government support. The country is taking dramatic steps to promote these cures even as researchers raise concerns about such treatments. [Nature News] Editorial United States Bans Most Government Scientists from Travel to Cuba To celebrate its 80th anniversary, the Pedro KourĂ Institute of Tropical Medicine (IPK) is throwing a birthday bash: a conference that several U.S. collaborators were planning to attend. All but one has backed out, says IPK virologist MarĂa Guadalupe Guzmán. Some, she says, were unsettled by recent claims that U.S. diplomats in Cuba suffered what the Department of State has described as “health attacks.” [ScienceInsider] Editorial Zimbabwe’s Researchers Hope Political Change Will Revitalize Science Academics are optimistic that the end of Robert Mugabe’s authoritarian rule could boost research and international collaboration. [Nature News] Editorial Gene Therapy Hits a Peculiar Roadblock: A Virus Shortage Eager to speed development of revolutionary treatments, the Food and Drug Administration recently announced that it would expedite approval of experimental gene therapies. But the regulatory process may not be the biggest obstacle. [The New York Times] Editorial
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EVENTSNEW SYStem – Symposium for the Next Generation of Stem Cell Researchers Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Student – Stem Cells in Tumor Initiation (German Cancer Research Center) NEW Postdoctoral Research Fellow – Cancer Stem Cells (Queen Mary University of London) Postdoctoral Fellows – Cancer/Stem Cell Biology (Stanford University) Postdoctoral Fellows – Medulloblastoma and Glioblastoma Multiforme (University of Toronto) Postdoctoral Research Fellow – Cancer Cell Signaling (University of Sussex) Postdoctoral Fellow – Cancer Stem Cell Research (University of Pennsylvania) Scientist – Tumor Microenvironment and Cancer Stem Cells (Evotec Toulouse) Faculty Positions – Cancer and Stem Cell Biology (Sun Yat-Sen University) Postdoctoral Fellows – Cancer Stem Cell Biology (Genome Institute of Singapore) Research Officers – Cancer Stem Cell Biology (Genome Institute of Singapore) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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