Fev Regulates Hematopoietic Stem Cell Development via ERK Signaling The authors showed that Fev, an ETS transcription factor, is a pivotal regulator of hematopoietic stem cell (HSC) development in vertebrates. Experiments performed with purified cord blood showed that fev is expressed and functions in primitive HSCs in humans, indicating its conserved role in higher vertebrates. [Blood] Abstract Human Placenta-Derived Mesenchymal Stem Cells Promote Hepatic Regeneration in CCl4-Injured Rat Liver Model via Increased Autophagic Mechanism Scientists investigated autophagy’s activation in carbon tetrachloride (CCl4)-injured rat liver following transplantation with chorionic plate-derived mesenchymal stem cells isolated from placenta. [Stem Cells] Abstract Shear Stress Activates Extracellular Signal-Regulated Kinase 1/2 via the Angiotensin II Type 1 Receptor Whether the angiotensin II AT1 receptor transduces shear stress in endothelial cells is unknown. Researchers exposed human umbilical cord endothelial cells to a shear stress of 0 (control) or 15 dyn/cm2 for 5 or 10 min. [FASEB J] Abstract Microvesicles Derived from Human Umbilical Cord Wharton’s Jelly Mesenchymal Stem Cells Attenuate Bladder Tumor Cell Growth In Vitro and In Vivo Researchers evaluated whether microvesicles derived from human umbilical cord Wharton’s jelly mesenchymal stem cells may inhibit bladder tumor T24 cells growth using cell culture and the BALB/c nu/nu mice xenograft model. [PLoS One] Full Article Characteristics of Chronic GvHD after Cord Blood Transplantation Investigators used traditional criteria and National Institutes of Health criteria prospectively to evaluate chronic GvHD in a cohort of 87 adult and pediatric recipients of single or double unrelated cord blood transplantation for treatment of hematologic malignancies. [Bone Marrow Transplant] Abstract Differential MicroRNA Signature of Human Mesenchymal Stem Cells from Different Sources Reveals an “Environmental-Niche Memory” for Bone Marrow Stem Cells To identify microRNAs (miRNAs) that can discriminate among mesenchymal stem cells (MSCs), researchers performed a whole-genome comparative miRNA expression profiling analysis on adipose, bone marrow and cord blood derived MSCs, all three considered among the most promising in the field of regenerative medicine. [Exp Cell Res] Abstract Analysis of Oxygen-Dependent Cytokine Expression in Human Mesenchymal Stem Cells Derived from Umbilical Cord Investigators analyzed the oxygen-dependent cytokine expression of human mesenchymal stem cells derived from umbilical cord and attempted to link the results to the proliferation and differentiation capacities of these cells. [Cell Tissue Res] Abstract Maturation of Toll-Like Receptor 1-4 Responsiveness during Early Life In order to achieve a more complete understanding of the ontogeny of immune system during the first years of life, researchers investigated age-matched toll-like receptor 1-4 responsiveness at several time points up to the age of two years. Mononuclear cells were isolated from cord blood and peripheral blood from infants at 6, 12, and 24 months of age, and from 50 adults. [Early Hum Dev] Abstract |