Inhibition of T Cell Protein Tyrosine Phosphatase (TC-PTP) Enhances IL-18-Dependent Hematopoietic Stem Cell Expansion Researchers reported that inhibition of TC-PTP, an enzyme involved in the regulation of cytokine signaling, through gene knockout results in a 9-fold increase in the number of hematopoietic progenitors in murine bone marrow (BM). This effect could be reproduced using a short treatment with a pharmacological inhibitor of TC-PTP in murine BM, as well as in human BM, peripheral blood and cord blood. [Stem Cells] Abstract | Full Article Proteasome Inhibition Upregulates Bim and Induces Caspase-3-Dependent Apoptosis in Human Mast Cells Expressing the Kit D816V Mutation The authors investigated here whether prevention of Bim degradation by a proteasomal inhibitor, MG132, would induce apoptosis in mast cells with the D816V mutation. Human umbilical cord blood-derived mast cells with wild-type Kit and two different subclones of the human mast cell line-1 were used for the study. [Cell Death Dis] Full Article Rapid T-Cell Chimerism Switch and Memory T-Cell Expansion Are Associated with Pre-Engraftment Immune Reaction Early after Cord Blood Transplantation Scientists reported the engraftment kinetics of donor-derived T cells using a multicolor flow cytometry-based method and also described the results of naïve/memory T-cell phenotype analyses early after cord blood transplantation. [Br J Haematol] Full Article Characterization of a Distinct Population of Circulating Human Non-Adherent Endothelial Forming Cells and Their Recruitment via Intercellular Adhesion Molecule-3 Investigators isolated, enriched for and then characterized a human umbilical cord blood derived CD133+ population of non-adherent endothelial forming cells which expressed the hematopoietic progenitor cell markers together with mature endothelial cell markers. [PLoS One] Full Article Pdx1 and Controlled Culture Conditions Induced Differentiation of Human Amniotic Fluid-Derived Stem Cells to Insulin-Producing Clusters Scientists investigated the differentiation of human amniotic fluid-derived stem cells into insulin-producing clusters in vitro. [J Tissue Eng Regen Med] Abstract Use of Poly(DL-Lactide-ε-Caprolactone) Membranes and Mesenchymal Stem Cells from the Wharton’s Jelly of the Umbilical Cord for Promoting Nerve Regeneration in Axonotmesis: In Vitro and In Vivo Analysis Researchers evaluated the therapeutic value of human umbilical cord matrix mesenchymal stem cells on rat sciatic nerve after axonotmesis injury associated to Vivosorb® membrane. [Differentiation] Abstract Generation of Induced Pluripotent Stem Cells from Human Amniotic Fluid Cells by Reprogramming with Two Factors in Feeder-Free Conditions Investigators showed that induced pluripotent stem cells can be generated from human amniotic fluid cells with two transcription factors: OCT4 and KLF4. [J Reprod Dev] Abstract MicroRNAs as Markers for Neurally Committed CD133+/CD34+ Stem Cells Derived from Human Umbilical Cord Blood Neural differentiation of the CD133+/CD34+ subpopulation of human umbilical cord blood stem cells was investigated, and neuro-microRNA expression was examined. [Biochem Genet] Abstract | Full Article |