Hematopoietic Colony Formation from Human Growth Factor-Dependent TF1 Cells and Human Cord Blood Myeloid Progenitor Cells Depends on Shp2 Phosphatase Function To verify the role of Shp2 phosphatase function in human hematopoietic cell development, human cord blood CD34+ cells were transduced with a leukemia-associated phosphatase gain-of-function Shp2 mutant or with a phosphatase dead Shp2 mutant, which indicated that increased phosphatase function enhanced, while decreased Shp2 phosphatase function reduced, human cord blood-derived colonies. [Stem Cells Dev] Abstract Factors with an Impact on Chimerism Development and Long-Term Survival after Umbilical Cord Blood Transplantation Researchers performed a retrospective single-center analysis of 50 umbilical cord blood transplantations performed from 2001 to 2010, including 37 single and 13 double umbilical cord blood transplantations. [Transplantation] Abstract Hematopoietic Cell Transplantation with Cord Blood for Cure of HIV Infections Researchers hypothesized that cure of HIV infections by hematopoietic cell transplantation can be accomplished using umbilical cord blood stem cells obtained from a modestly sized inventory of cryopreserved CCR5-Δ32/Δ32 cord blood units. [Biol Blood Marrow Transplant] Abstract Immune Reconstitution Kinetics as an Early Predictor for Mortality Using Various Hematopoietic Stem Cell Sources in Children Scientists investigated differences in immune reconstitution with different cell sources and the association between the kinetics of immune reconstitution and mortality. Lymphocyte reconstitution in the first three months after hematopoietic stem cell transplantation (HSCT) was studied in relation to mortality in three HSCT-groups: matched sibling bone marrow, unrelated bone marrow, and unrelated cord blood. [Biol Blood Marrow Transplant] Abstract MiR-16 Inhibits the Proliferation and Angiogenesis-Regulating Potential of Mesenchymal Stem Cells in Severe Pre-Eclampsia MicroRNA(miR)-16-over-expressed decidua-derived mesenchymal stem cells reduced the ability of human umbilical vein endothelial cells to form blood vessels and the migration of the trophoblast cells. [FEBS J] Abstract Immune Reconstitution after Combined Haploidentical and Umbilical Cord Blood Transplantation Overall, immune reconstitution after haplo-cord transplantation was similar to that seen after cord blood transplantation, despite infusion of much lower cord blood cell dose. [Leuk Lymphoma] Abstract Repair and Regeneration of Skin Injury by Transplanting Microparticles Mixed with Wharton’s Jelly and MSCs from the Human Umbilical Cord Researchers explored a new strategy for treating skin wounds. A mixture of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells, Wharton’s jelly, and skin microparticles were transplanted to 10-mm diameter, full-thickness, middorsal, excisional skin wounds of mice. [Int J Low Extrem Wounds] Abstract |