Cord Blood News Volume 4.37 | Sep 20 2012

Human Interferon-Alpha Increases the Cytotoxic Effect of CD56⁺ Cord Blood-Derived Cytokine-Induced Killer Cells on Human B-Acute Lymphoblastic Leukemia Cell Lines
Researchers investigated the possibility of combining adoptive immunotherapy with cytokine-induced killer (CIK) cells and human interferon-alpha (hIFN-a) in order to potentiate the cytotoxicity of CIK cells against B-lineage acute lymphoblastic leukemia (B-ALL). Cord blood- derived CIK cells were differentiated, stimulated with phosphate-buffered saline or hIFN-a, and tested for cytotoxic activity. [Cytotherapy] Abstract

Correlation of Infused CD3+CD8+ Cells on Single-Donor Dominance after Double Unit Cord Blood Transplantation
Data indicated that a greater total CD3⁺/kg cell dose and in particular naïve CD3⁺CD8⁺ T-cells, may play an important role in determining single donor dominance after double cord blood transplantation. [Biol Blood Marrow Transplant] Abstract

Development of a New Humanized Mouse Model to Study Acute Inflammatory Arthritis
One to two-day old irradiated NOD-scid IL2rgammanull (NSG) mice were reconstituted with human CD34+ cord blood stem cells. Arthritis was induced by injecting complete Freund’s adjuvant into knee or ankle joints. [J Transl Med] Abstract

Notch Signals Contribute to Preserve the Multipotentiality of Human CD34+CD38-CD45RA-CD90+ Hematopoietic Progenitors by Maintaining T Cell Lineage Differentiation Potential
Researchers identified cord blood CD34+CD38-CD45RA-CD90+ cells as one of the earliest targets of Notch in human hematopoiesis. Upon Notch activation CD34+CD38- cells are blocked in their differentiation at the CD34+CD38-CD45RA-CD90+ stage. Notch signaling is required before lymphoid commitment to preserve T-cell potential of CD34+CD38-CD45RA-CD90+ cells. [Exp Hematol] Abstract

Co-Culture with Sertoli Cells Promotes Proliferation and Migration of Umbilical Cord Mesenchymal Stem Cells
Scientists isolated human umbilical cord mesenchymal stem cells (hUCMSCs) from human cords and Sertoli cells from mouse testes, and co-cultured them using a Transwell system. Findings indicated that Sertoli cells boost UCMSC proliferation and migration potential. [Biochem Biophys Res Commun] Abstract

Maintenance and Characterization of Multipotent Mesenchymal Stem Cells Isolated from Canine Umbilical Cord Matrix by Collagenase Digestion
Mesenchymal stem cells (MSCs) were successfully isolated from canine umbilical cord matrix by collagenase digestion and further characterized for multipotent properties associated with MSCs. [Res Vet Sci] Abstract

Expression of P16 Cell Cycle Inhibitor in Human Cord Blood CD34+ Expanded Cells following Co-Culture with Bone Marrow-Derived Mesenchymal Stem Cells
mRNA expression and promoter methylation status of p16 were evaluated during cord blood hematopoietic stem cell ex vivo expansion using cytokines and a co-culture system with mesenchymal stem cells feeder layer. [Hematology] Abstract

Unrelated Cord Blood Transplantation for Patients with Adult T-Cell Leukemia/Lymphoma: Experience at a Single Institute
Researchers report the results of unrelated cord blood transplantation for patients with adult T-cell leukemia/lymphoma conducted in a single institute. [Int J Hematol] Abstract

ThermoGenesis Announces New Cord Blood Products Distribution Agreements
ThermoGenesis Corp. announced that it has signed two additional new channel partner agreements as part of its continuing program to enhance its distribution, technical service and clinical support initiatives of its cord blood products. [ThermoGenesis Corp.] Press Release

China Cord Blood Corporation and Golden Meditech Holdings Limited Enter into Convertible Note Financing to Further Expand Cord Blood Banking Services
China Cord Blood Corporation (CBCC) and Golden Meditech Holdings Limited announced that they entered into agreements under which Golden Meditech, is expected to invest $50 million into CCBC to support its further business expansion and to capitalize on China’s fast-growing healthcare services industry. [China Cord Blood Corporation] Press Release

America Stem Cell, Inc. Awarded a Phase I STTR to Explore the Therapeutic Potential of Its Platform Technology (ASC-101) with Amniotic Fluid-Derived Stem Cells
America Stem Cell, Inc. (ASC) announced that it has been awarded an Advanced Technology Small Business Technology Transfer Research (STTR) grant from the National Heart Lung and Blood Institute at the National Institutes of Health. They will examine the effect of ASC-101-treated amniotic fluid-derived stem cells in an experimental model of compartment syndrome. [Business Wire] Press Release

Upstate Breaks Ground for Umbilical Cord Blood Bank
Upstate Medical University will begin construction on a $15 million Upstate Cord Blood Bank that will collect, process and store umbilical cord blood donated by families throughout Central and northern New York to be used by those in need of life-saving medical treatments and for medical research. [SUNY Upstate Medical University] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

Clinical Lab Scientist – Cord Blood (Cardinal Glennon Children’s Medical Center)

Research Associate – Quality Assurance (University of California)

Postdoctoral Position in Mouse Stem Cell Biology (University of Alabama at Birmingham)

Postdoctoral Fellow in Stem Cells and Cancer (Tsinghua University)


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