Risk Factors Associated with Increased Non-Relapse Mortality and with Poor Overall Survival in Children with Chronic Graft-Versus-Host Disease Researchers performed multivariate analyses to identify risk factors for non-relapse mortality and survival in 1117 pediatric subjects with leukemia or myelodysplastic syndrome, transplanted from related donors, unrelated donors or unrelated cord blood between 1995-2004. [Blood] Abstract Ontogeny Stage-Independent and High-Level Clonal Expansion In Vitro of Mouse Hematopoietic Stem Cells Stimulated by an Engineered NUP98-HOX Fusion Transcription Factor The findings point to the effects of NUP98-HOXA10hd on hematopoietic stem cells in vitro being mediated by promoting self-renewal and set the stage for further dissection of this process. [Blood] Abstract Core–Shell Cell Bodies Composed of Human cbMSCs and HUVECs for Functional Vasculogenesis In the study, researchers used a thermo-responsive hydrogel system to fabricate core–shell cell bodies composed of cord-blood mesenchymal stem cells (cbMSCs) and human umbilical vascular endothelial cells (HUVECs) for functional vasculogenesis. [Biomaterials] Abstract Very Small Embryonic-Like Stem Cells with Maximum Regenerative Potential Get Discarded During Cord Blood Banking and Bone Marrow Processing for Autologous Stem Cell Therapy Very small embryonic-like stem cells are possibly lost during cord blood banking and bone marrow (BM) processing for autologus stem cell therapy mainly because of their small size. The present study was conducted on human umbilical cord blood and discarded red blood cells fraction obtained after separation of mononuclear cells from human BM, to test this hypothesis. [Stem Cells Dev] Abstract MicroRNA and Messenger RNA Analyses of Mesenchymal Stem Cells Derived from Teeth and the Wharton Jelly of Umbilical Cord This study has integrated the use of microRNA and messenger RNA expression profiles to analyze human mesenchymal stem cells derived from Wharton’s jelly of the umbilical cord, milk teeth, and adult wisdom teeth. [Stem Cells Dev] Abstract Immune Reconstitution After Double Umbilical Cord Blood Stem Cell Transplantation: Comparison with Unrelated Peripheral Blood Stem Cell Transplantation To define the differences in immune reconstitution between double umbilical cord blood (DUCB) transplantation and human leukocyte antigen-matched unrelated donor transplantation, researchers performed a detailed, prospective analysis of immune reconstitution in 42 DUCB recipients and 102 filgrastim-mobilized unrelated peripheral blood stem cell recipients. [Biol Blood Marrow Transplant] Abstract The Saudi Experience in Fludarabine-Based Conditioning Regimens for Fanconi Anemia Patients Undergoing Stem Cell Transplantation: Excellent Outcome in Recipients of Matched Related Stem Cells but Not in Recipients of Unrelated Cord Blood Stem Cells Scientists conclude that the combination of cyclophosphamide, fludarabine, and antithymocyte globulin in the doses used in this study is well tolerated, and that the proclaimed positive effect of adding flu to the conditioning regimens of Fanconi anemia patients is most pronounced in recipients of HLA-matched related stem cell transplantation. [Biol Blood Marrow Transplant] Abstract Cell Recovery Comparison Between Plasma Depletion/Reduction- and Red Cell Reduction-Processing of Umbilical Cord Blood The data indicates that plasma depletion/reduction processing of cord blood provides a significantly more efficient usage of this valuable and scarce resource. [Cytotherapy] Abstract A Cross-Sectional Study of Umbilical Cord Blood Donor Profiles and Their Influence on Umbilical Cord Blood Collection in a Brazilian Hospital The aim was to describe the donor population and assess the best cord blood collection technique at Hospital Israelita Albert Einstein’s cord blood bank (São Paulo, Brazil). [Cytotherapy] Abstract Differential Macrophage Polarization Promotes Tissue Remodeling and Repair in a Model of Ischemic Retinopathy In this study researchers show that umbilical cord blood-derived CD14+ progenitor cells provide rescue effects in a mouse model of ischemic retinopathy by promoting physiological angiogenesis and reducing associated inflammation. [Sci Rep] Abstract |