Reduced Intensity Conditioning Transplantation in Acute Leukemia: The Effect of Source of Unrelated Donor Stem Cells on Outcomes Investigators report the relative efficacy of co-infusing two umbilical cord blood units compared to peripheral blood progenitor cells from 8/8 or 7/8 HLA matched unrelated donors. [Blood] Abstract TET2 Is Essential for Survival and Hematopoietic Stem Cell Homeostasis Researchers’ data indicates that ten-eleven-translocation 2 (TET2) plays a critical role in survival and hematopoietic stem cell homeostasis. [Leukemia] Abstract Human Insulin Secreted from Insulinogenic Xenograft Restores Normoglycemia in Type I Diabetic Mice without Immunosuppression Researchers examined therapeutic potential of human amnion-derived insulin-secreting cells for type 1 diabetes. Human amniotic mesenchymal stem cells were isolated from amnion, and cultivated to differentiate into insulin-secreting cells in vitro. [Cell Transplant] Abstract RNA Sensors Enable Human Mast Cell Anti-Viral Chemokine Production and Interferon-Mediated Protection in Response to Antibody-Enhanced Dengue Virus Infection In order to obtain a global view of dengue virus-induced gene regulation in mast cells, primary human cord blood-derived mast cells and the KU812 and HMC-1 mast cell lines were infected with dengue virus in the presence of dengue-immune sera and their responses were evaluated at the mRNA and protein levels. [PLoS One] Abstract Twice Daily i.v. Bolus Tacrolimus Infusion for GvHD Prophylaxis in Children Undergoing Stem Cell Transplantation Researchers investigated the safety and efficacy of twice daily bolus infusions of i.v. tacrolimus in 33 children undergoing hematopoietic stem cell transplantation. [Bone Marrow Transplant] Abstract Human Monocyte Responsiveness to the Commensal Bacterium Staphylococcus epidermidis Develops Late in Gestation Cord and peripheral blood mononuclear cells were stimulated with Staphylococcus epidermidis and a range of innate immune responses assessed, including phagocytosis, intracellular killing, Toll-like receptor (TLR) pathway transcriptional activation, cytokine production, TLR2 and TLR4 expression and cell signaling. [Pediatr Res] Abstract Comparison of Immunomodulatory Effects of Placenta Mesenchymal Stem Cells with Bone Marrow and Adipose Mesenchymal Stem Cells Researchers examined and compared immunomodulatory function of chorionic plate-derived mesenchymal stem cells (MSCs) with that of bone marrow-derived MSCs and adipose-derived MSCs using co-culture system with activated T-cells derived from human umbilical cord blood exposed to anti-CD3 and anti-CD28 which are T-cell activating monoclonal antibodies. [Int Immunopharmacol] Abstract Cord Blood Interleukin-6 Predicts Neonatal Morbidities In Pcr Positive Ureaplasma urealyticum Preterm Infants Researchers’ objectives were to evaluate the clinical significance of Ureaplasma urealyticum recovery from umbilical cord blood, using PCR, and its association to umbilical cord interleukin-6 levels and neonatal morbidity in preterm infants. [J Matern Fetal Neonatal Med] Abstract |