The ATM–BID Pathway Regulates Quiescence and Survival of Hematopoietic Stem Cells Researchers show that ATM-mediated BID phosphorylation plays an unexpected role in maintaining the quiescence of hematopoietic stem cells. [Nat Cell Biol] Abstract The miR-17-92 Cluster Expands Multipotent Hematopoietic Progenitors While Imbalanced Expression of its Individual Oncogenic miRNAs Promotes Leukemia in Mice The present study demonstrates that retroviral-mediated miR-17-92 overexpression promotes expansion of multipotent hematopoietic progenitors in mice. [Blood] Abstract Intrapancreatic Delivery of Human Umbilical Cord Blood Aldehyde Dehydrogenase-Producing Cells Promotes Islet Regeneration Researchers sought to investigate the stimulation of islet regeneration by transplanted human umbilical cord blood cells purified according to high aldehyde dehydrogenase activity, a conserved characteristic of multiple progenitor lineages. [Diabetologia] Abstract T-Cell Replete Fludarabine/Cyclophosphamide Reduced Intensity Allogeneic Stem Cell Transplantation for Lymphoid Malignancies Investigators report the outcome of 73 patients with lymphoid malignancies who received reduced-intensity allogeneic stem cell transplantation with a fludarabine/cyclophosphosphamide conditioning regimen and a median follow-up of 3 years. [Br J Haematol] Abstract High Efficiency of Reprogramming CD34+ Cells Derived from Human Amniotic Fluid into Induced Pluripotent Stem Cells with Oct4 To generate induced pluripotent stem cells, CD34+ cells, isolated from human amniotic fluid cells by flow cytometry, were infected with retroviruses carrying only one reprogramming factor (Oct4) and cultured on human amniotic epithelial cell feeder layers. [Stem Cells Dev] Abstract Non-Rigid Calcium Phosphate Cement Containing Hydrogel Microbeads and Absorbable Fibers Seeded with Umbilical Cord Stem Cells for Bone Engineering The objectives of this study were to develop a non-rigid calcium phosphate cement (CPC) with microbeads and fiber reinforcement; and investigate human umbilical cord mesenchymal stem cell proliferation, osteodifferentiation and mineralization on non-rigid CPC for the first time. [J Tissue Eng Regen Med] Abstract Safety and Feasibility of Countering Neurological Impairment by Intravenous Administration of Autologous Cord Blood in Cerebral Palsy Scientists conducted a pilot study of the infusion of intravenous autologous cord blood in children with cerebral palsy to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment. [J Transl Med] Abstract Allogeneic Hematopoietic Stem Cell Transplant with Reduced-Intensity Conditioning for Chronic Lymphocytic Leukemia in Sweden: Does Donor T-Cell Engraftment 3 Months After Transplant Predict Survival? Thirty-eight adult patients with chronic lymphocytic leukemia underwent reduced-intensity conditioning allogeneic stem cell transplant in Sweden between 1999 and 2007. [Leuk Lymphoma] Abstract |