Single-Unit Umbilical Cord Blood Transplantation from Unrelated Donors in Patients with Hematological Malignancy Using Busulfan, Thiotepa, Fludarabine and ATG as Myeloablative Conditioning Regimen This study shows high rates of engraftment with fast neutrophil recovery in patients undergoing single-unit cord blood transplantation using a BU-based conditioning regimen. [Bone Marrow Transplant] Abstract Comparative Study of Regulatory T Cells Expanded Ex Vivo from Cord Blood and Adult Peripheral Blood In this study, researchers expanded regulatory T cells (Tregs) ex vivo from CD4+CD25+ T cells from cord blood and CD4+CD25+CD127- T cells from adult peripheral blood and compared the suppressive functions of the newly generated Tregs. [Immunology] Abstract Unrelated Donor Cord Blood Transplantation for Children with Severe Sickle Cell Disease: Results of One Cohort from the Phase II Study from the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) The sickle cell unrelated donor transplant trial of the BMT CTN is a phase II study of the toxicity and efficacy of unrelated donor hematopoietic cell transplantation in children with severe sickle cell disease using a reduced intensity conditioning regimen. Here investigators report the results for the cord blood cohort of this trial. [Biol Blood Marrow Transplant] Abstract Human Umbilical Cord Provides a Significant Source of Unexpanded Mesenchymal Stromal Cells This study demonstrates that, using umbilical cord, large numbers of mesenchymal stromal cells (MSC) can be safely obtained using a simple procedure without in vitro expansion, and these non-expanded MSC have the potential to suppress graft-versus-host disease. [Cytotherapy] Abstract Human Umbilical Cord Mesenchymal Stem Cells Improve Liver Function and Ascites in Decompensated Liver Cirrhosis Patients This study examined the safety and efficacy of umbilical cord-derived mesenchymal stem cells in patients with decompensated liver cirrhosis. [J Gastroenterol Hepatol] Abstract Successful Unrelated Umbilical Cord Blood Transplantation in Lesch-Nyhan Syndrome As hematopoietic stem cell transplantation has been shown to be effective in several neurodevelopmental inborn errors, researchers hypothesized that it could be favorable in Lesch-Nyhan syndrome as well. [Metab Brain Dis] Abstract Distribution of CD4+CD25highFoxP3+ Regulatory T-Cells in Umbilical Cord Blood This study aimed to establish reference intervals for lymphocyte subsets including CD4+CD25highFoxP3+ regulatory T-cells in umbilical cord blood. [J Matern Fetal Neonatal Med] Abstract New Approach for Isolation of Mesenchymal Stem Cells (MSCs) from Human Umbilical Cord Blood The aim of this study was to establish a new method for isolating large number of MSCs from the human umbilical cord blood in order to be recognized as a good source of MSCs. [Cell Biol Int] Abstract Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells (hUCB-MSC) Inhibit the Proliferation of K562 (Human Erythromyeloblastoid Leukemic Cell Line) The objectives of this study were to evaluate the effect of hUCB-MSC on the proliferation of K562 and the cytokine secretion pattern of hUCB-MSC. [Cell Biol Int] Abstract |