Upfront Allogeneic Blood Stem Cell Transplantation for Patients with High Risk Myelodysplastic Syndrome or Secondary Acute Myeloid Leukemia Using a FLAMSA-Based High-Dose Sequential Conditioning Regimen The purpose of the prospective single center study was to examine the safety and efficacy of an allogeneic hematopoietic stem cell transplantation following a sequential conditioning regimen as first line therapy for previously untreated patients with high risk myelodysplastic syndrome (MDS) or AML secondary to MDS. [Blood] Abstract Haplo-Identical/Mismatched Hematopoietic Stem Cell Transplantation Without In Vitro T-Cell Depletion for T-Cell Acute Lymphocytic Leukemia The study confirmed that haplo-identical/mismatched hematopoietic stem cell transplantation could be an alternative treatment choice for T-cell acute lymphoblastic leukemia. [Blood] Abstract The Effect of Folinic Acid on Methylenetetrahydrofolate Reductase Polymorphisms in Methotrexate Treated Allogeneic Haematopoietic Stem Cell Transplants The study examined the contribution single nucleotide polymorphisms of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene have on clinical outcomes in hematopoietic stem cell transplant patients treated with the anti-proliferative drug methotrexate. [Blood] Abstract DEK Regulates Hematopoietic Stem Engraftment and Progenitor Cell Proliferation Researchers hypothesized that DEK may modulate functions of hematopoietic stem and progenitor cells. [Stem Cells Dev] Abstract Compartmental Hollow Fiber Capillary Membrane Based Bioreactor Technology for In Vitro Studies on Red Blood Cell Lineage Direction of Hematopoietic Stem Cells The down-scaled culture technology allows for expansion of CD34+ cells and stimulating these progenitors towards red blood cell lineage, expressing approximately 40% CD235+ and enucleation. [Tissue Eng Part C Methods] Abstract Role of HLA-G and NCR in Protection of Umbilical Cord Blood Haematopoietic Stem Cells from NK Cell Mediated Cytotoxicity The studies aimed at investigating potential mechanisms of allogeneic umbilical cord blood haematopoietic stem cells escape from the cytolysis of natural killer (NK) cells. [J Cell Mol Med] Abstract Factors Predicting Single-Unit Predominance After Double Umbilical Cord Blood Transplantation The study examined the risk factor associated with unit predominance in 262 patients with hematologic malignancies who underwent double umbilical cord blood transplantation with subsequent hematopoietic recovery and complete chimerism between 2001 and 2009. [Bone Marrow Transplant] Abstract Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood The aim of the study was to characterize the CD25-expressing subset of B cells in human cord blood. [Clin Dev Immunol] Abstract A New Methodological Sequence to Expand and Transdifferentiate Human Umbilical Cord Blood Derived CD133+ Cells into a Cardiomyocyte-Like Phenotype In this study researchers investigated optimising a protocol for the expansion and subsequent differentiation of human umbilical cord blood derived CD133+ stem cells into a cardiomyocyte-like lineage. [Stem Cell Rev Rep] Abstract Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells After Intrathecal Administration by Lumbar Puncture in a Rat Model of Cerebral Ischemia To determine the therapeutic potential of intrathecal administration of mesenchymal stem cells (MSCs) by lumbar puncture, investigators administrated human umbilical cord blood-derived MSCs (hUCB-MSCs) intrathecally into the lumbar spinal cord or intravenously into the tail vein in a rat model of stroke, and then investigated whether hUCB-MSCs could enter the brain, survive, and improve poststroke neurological functional recovery. [Stem Cell Res Ther] Abstract |