Cord Blood News Volume 2.12 | Apr 1 2010

May 12, 2022

Cord Blood News 2.12, April 1, 2010.

In this issue: Science News | Current Publications | Industry News | Policy News | Events

Bone Progenitor Dysfunction Induces Myelodysplasia and Secondary Leukemia
By examining how mesenchymal osteolineage cells modulate hematopoiesis, researchers show that deletion of Dicer1 specifically in mouse osteoprogenitors, but not in mature osteoblasts, disrupts the integrity of hematopoiesis. [Nature]

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SCIENCE NEWS

Targeting Cell Pathway May Prevent Relapse of Leukemia
Researchers show that leukemia stem cells cannot thrive without a particular cell pathway, known as the Wnt/beta-catenin pathway, suggesting that targeting this pathway may prevent the growth and development of acute myelogenous leukemia. [Press release from PR Newswire discussing online prepublication in Science]

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CURRENT PUBLICATIONS

The Wnt/Beta-Catenin Pathway is Required for the Development of Leukemia Stem Cells in Acute Myelogenous Leukemia
Because the Wnt/beta-catenin pathway is normally active in hematopoietic stem cells but not in granulocyte-macrophage progenitors, these results suggest that reactivation of beta-catenin signaling is required for the transformation of progenitor cells by certain oncogenes. [Science]

Long-Term Study of Indolent Adult T-Cell Leukemia-Lymphoma
The prognosis of indolent adult T-cell leukemia-lymphoma (ATL) in this study was poorer than expected. These findings suggest that even “indolent” ATL patients should be carefully observed in clinical practice. [Blood]

Cytotherapy with Naive Rat Umbilical Cord Matrix Stem Cells Significantly Attenuates Growth of Murine Pancreatic Cancer Cells and Increases Survival in Syngeneic Mice
Results indicate that naive rat umbilical cord matrix-derived stem cells alone remarkably attenuate the growth of pancreatic carcinoma cells in vitro and in a mouse peritoneal model. [Cytotherapy]

Hypoxia Responsive Mesenchymal Stem Cells Derived from Human Umbilical Cord Blood are Effective for Bone Repair
Researchers report that mesenchymal stem cells can be separated into two subpopulations based on aldehyde dehydrogenase activity. [Stem Cells Dev]

Isolation and Differentiation of Mesenchymal Stem Cells from Bovine Umbilical Cord Blood
In this study, the cells with spindle morphology from seven of nine bovine umbilical cord blood samples were isolated and cultured. These mesenchymal stromal cells were successfully differentiated to osteocytes, chondrocytes and adipocytes. [Reprod Domest Anim]

In Vitro Culture of Keratinocytes from Human Umbilical Cord Blood Mesenchymal Stem Cells: The Saigonese Culture
This study was designed to investigate whether keratinocytes could be obtained directly from human umbilical cord blood mesenchymal stem cells in vitro. [Cell Tissue Bank]

INDUSTRY NEWS

Cerus Signs Agreement with Swiss Red Cross for Deployment of the INTERCEPT Blood System for Platelets
Cerus Corporation announced that it has signed a three-year purchase agreement with the Swiss Red Cross Blood Service, with terms that anticipate deployment of the INTERCEPT Blood System for platelets in eleven of its thirteen blood centers. [Cerus Corporation Press Release]

Boehringer Ingelheim Launches Global Venture Fund to Foster Innovation in Life Sciences
Boehringer Ingelheim announced the launch of its corporate venture capital fund, the Boehringer Ingelheim Venture Fund. [Boehringer Ingelheim Press Release]

Cord Blood Bank Opening New Lab in Maitland, Hiring 31
Orlando-based Cord:Use wants to move into a larger building with a new medical laboratory in Maitland by and expand from 20 to 40 local employees during the next three years. [Orlando Business Journal]

BloodCenter to Operate Organ, Tissue Bank
Two groups that procure organs, veins, heart valves and other tissue have been consolidated into the BloodCenter of Wisconsin, making it the only organization in the country that specializes in all types of donation. [Journal Sentinel]

Question Mark Over Utility of Cord Blood Banking
Coming down heavily on the practice of private cord blood banking, Brig Velu Nair, head of the Department of Clinical Hematology, Army Hospital New Delhi and Dean of the Army College of Medical Sciences said there is no scientific justification for the ‘autologous storage of umbilical cord blood.’ [Indian Express]

Experts Cheer Plan for Gilbert Stem Cell Center
The Celebration Stem Cell Centre is preparing to register with the Food and Drug Administration and hopes to begin processing billions of life-saving stem cells by mid-June. [The Arizona Republic]

POLICY NEWS

Government Accountability Office: FDA Needs Better Plans To Protect Public Health
The U.S. Food and Drug Administration (FDA) is facing significant planning and management challenges that could affect its ability to protect the public health, according to a report by the Government Accountability Office. [Food and Drug Administration, United States]

Notice of Termination of Selected Research Training and Research Career Development Award Funding Opportunity Announcements (NOT-OD-10-069) [National Institutes of Health, United States]

Final Ruth L. Kirschstein National Research Service Award (Kirschstein-NRSA) Policy for Tuition, Fees, and Health Insurance on Training Grants and Fellowships (NOT-OD-10-073) [National Institutes of Health, United States]

Waivers for Conflicts of Interest for the April 12, 2010 Blood Products Advisory Committee Meeting [Center for Biologics Evaluation and Research, United States]

Guidance for Industry on the Content and Format of the Dosage and Administration Section of Labeling for Human Prescription Drug and Biological Products; Availability [Docket No. FDA-2007-D-0201] [Food and Drug Administration, United States]

Advisory Committees; Technical Amendment [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practices; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Consultation: Proposed Standards for Hematopoietic Progenitor Cells Intended for Use in Hematopoietic Reconstitution [Therapeutic Goods Administration, Australia]

Infusion and Transfusion, Autologous: Blood Salvage System – Fresenius Kabi Ltd – C.A.T.S. Auto Transfusion System 9005101 [Medicines and Healthcare products Regulatory Agency, United Kingdom]

EVENTS

12th Biennial Canadian Blood and Marrow Transplant Group (CBMTG) Conference
April 7-10, 2010
Vancouver, Canada

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

British Society for Haematology 50th Annual Scientific Meeting
April 19-21, 2010
Edinburgh, Scotland