Effects of a Ceramic Biomaterial on Immune Modulatory Properties and Differentiation Potential of Human Mesenchymal Stromal Cells of Different Origin Researchers assessed the immune modulatory properties of human mesenchymal stromal cells (MSCs) obtained from bone marrow, fat and cord blood in presence of a hydroxyapatite and tricalcium-phosphate biomaterial as a scaffold for MSC delivery. [Tissue Eng Part A] Abstract Heterogeneous Functions of Perinatal Mesenchymal Stromal Cells Require a Preselection before Their Banking for Clinical Use Scientists aimed to compare adult bone marrow-mesenchymal stromal cells (MSCs) with MSCs from perinatal tissues (cord blood, umbilical cord, amnion, and chorion) on their in vitro immunological and stromacytic efficiencies under different priming conditions. [Stem Cells Dev] Abstract Transcriptomic Portrait of Human Mesenchymal Stromal/Stem Cells Isolated from Bone Marrow and Placenta Mesenchymal stromal/stem cell (MSC) primary cultures from human bone marrow and placenta were derived and verified by their immunophenotype standard pattern and trilineage differentiation potential. Then, a broad characterization of the transcriptome of these MSCs was performed using RNA deep sequencing. [BMC Genomics] Full Article Effect of Umbilical Cord Blood Prefreeze Variables on Postthaw Viability Researchers investigated factors measured before freezing of the umbilical cord blood that could affect overall postthaw viability of the stem cell unit from 257 collected cord blood samples. The analysis included hematologic variables, cord blood collection characteristics, and stem cell separation and preservation factors. [Transfusion] Abstract Umbilical Cord Wharton’s Jelly Repeated Culture System: A New Device and Method for Obtaining Abundant Mesenchymal Stem Cells for Bone Tissue Engineering Scientists designed and evaluated an umbilical cord Wharton’s jelly repeated culture device. Using this device, mesenchymal stem cells derived from human umbilical cord Wharton’s jelly were obtained from the repeated cultures and their quantities and biological characteristics were compared. [PLoS One] Full Article An Increase in CD3+CD4+CD25+ Regulatory T Cells after Administration of Umbilical Cord-Derived Mesenchymal Stem Cells during Sepsis With a cecal ligation and puncture (CLP) model, the mechanisms of mesenchymal stem cell (MSC)-mediated immunoregulation during sepsis were studied by determining the changes of circulating inflammation-associated cytokine profiles and peripheral blood mononuclear cells 18 hours after CLP-induced sepsis. In vitro, bone marrow-derived MSCs and umbilical cord-derived MSCs showed a similar morphology and surface marker expression. [PLoS One] Full Article Impact of Rabbit ATG-Containing Myeloablative Conditioning Regimens on the Outcome of Patients Undergoing Unrelated Single-Unit Cord Blood Transplantation for Hematological Malignancies Researchers assessed the impact of antithymocyte globulin (ATG) on patient outcome in a retrospective series of 91 patients who underwent unrelated single-unit cord blood transplantation following a myeloablative conditioning regimen. [Bone Marrow Transplant] Abstract Therapeutic Effects of Amniotic Fluid-Derived Mesenchymal Stromal Cells on Lung Injury in Rats with Emphysema Researchers analyzed the phenotypic characteristics, differentiation potential, and karyotype of rat amniotic fluid-derived mesenchymal stromal cells, which were isolated from pregnant Sprague-Dawley rats. [Respir Res] Full Article Umbilical Cord Blood CD34+ Stem Cells and Other Mononuclear Cell Subtypes Processed up to 96 Hours from Collection and Stored at Room Temperature Maintain a Satisfactory Functionality for Cell Therapy The authors recently demonstrated that cord blood mononuclear cell subtypes were viable and functional until 96 hours after collection, even stored at room temperature. In the present study they analyzed the viability and functionality of the cells before and after cryopreservation. [Vox Sang] Abstract |