Upfront Allogeneic-Stem Cell Transplantation for Patients with Non-Localized Untreated Peripheral T-Cell Lymphoma: An Intention-to-Treat Analysis from a Single Center Investigators assessed the feasibility and toxicity of upfront allogeneic stem cell transplantation (allo-SCT). 49 newly diagnosed peripheral T-cell lymphoma patients were scheduled to receive upfront allo-SCT. [Ann Oncol] Abstract Phase I/II Study of Nilotinib Prophylaxis after Allogeneic Stem Cell Transplantation in Patients with Advanced Chronic Myeloid Leukemia or Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Twenty-two patients with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia underwent stem cell transplantation with human leukocyte antigen-matched siblings, unrelated donors, or alternative donors. [Cancer] Abstract The Role of Hematopoietic Stem Cell Transplantation for Relapsed and Refractory Hodgkin Lymphoma Autologous and allogeneic hematopoietic stem cell transplantation (HSCT) were performed in 298 and 122 patients, respectively. For autologous HSCT, overall survival at three years (3yOS) was 70%, and sex, age, disease status, and performance status (PS) at HSCT were prognostic factors. For allogeneic HSCT, 3yOS was 43%, and sex and PS at HSCT were prognostic factors. [Am J Hematol] Abstract Biological Parameters Influencing the Human Umbilical Cord-Derived Mesenchymal Stem Cells’ Response to Retinoic Acid Using MTT assay and EB/AO staining as well as TUNEL assay scientists show that retinoic acid (RA) in a concentration-dependent manner induces apoptosis through upregulating Caspase expression and increasing Bax/Bcl2 ratio. Moreover, different biological parameters such as initial time seeding, cell density, passage number and duration of RA treatment play a major role in human umbilical cord-derived mesenchymal stem cells cytotoxic response to this agent. [Biofactors] Abstract Hematopoietic Stem Cell Transplantation for X-Linked Thrombocytopenia with Mutations in the WAS Gene To answer the question whether hematopoietic stem cell transplantation (HSCT) offers a viable therapeutic option in X-linked thrombocytopenia (XLT), researchers retrospectively investigated the outcome of HSCT in a cohort of 24 XLT patients who received HSCT at 14 transplant centers in the United States, Italy, Germany, Canada, and Japan. [J Clin Immunol] Abstract Successful Treatment of Metastatic Rhabdomyosarcoma with Radiochemotherapy and Allogeneic Hematopoietic Stem Cell Transplantation Researchers report a case of a 21-year-old man with alveolar rhabdomyosarcoma primarily in the right hand with lymph node, lung, bone and bone marrow metastases. Complete remission was achieved after intensive chemotherapy and radiotherapy of the primary and metastatic sites, followed by allogeneic peripheral blood stem cell transplantation with reduced-intensity conditioning from a single HLA-DR locus-mismatched mother. [Jpn J Clin Oncol] Abstract Fetal Heart Extract Facilitates the Differentiation of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells into Heart Muscle Precursor Cells Investigators aimed to improve the efficacy of differentiation of umbilical cord blood-derived mesenchymal stem cells into cardiomyocytes by combining 5-azacytidine with mouse fetal heart extract in the induction medium. [Cytotechnology] Abstract |