Senescence Associated MCP-1 Secretion Is Dependent on a Decline in BMI1 in Human Mesenchymal Stromal Cells The authors showed that positive feedback between senescence-associated secretory phenotype and inherent senescence processes plays a crucial role in the senescence of umbilical cord blood-derived mesenchymal stromal cells. [Antioxid Redox Signal] Abstract Injection of Human Cord Blood Cells with Hyaluronan Improves Postinfarction Cardiac Repair in Pigs Researchers tested whether injection of human cord blood mononuclear cells combined with hyaluronan hydrogel improves cell therapy efficacy in a pig myocardial infarction model. [Stem Cells Transl Med] Abstract Role of Keratinocyte Growth Factor in the Differentiation of Sweat Gland-Like Cells From Human Umbilical Cord-Derived Mesenchymal Stem Cells Investigators demonstrated that keratinocyte growth factor is a critical growth factor for sweat gland-like cells (SGC) differentiation from human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and the differentiated SGC from hUC-MSCs may have a potential therapeutic application for regeneration of destroyed sweat-glands and injured skin. [Stem Cells Transl Med] Abstract The Efficacy of Extraembryonic Stem Cells in Improving Blood Flow within Animal Models of Lower Limb Ischemia Scientists investigated the efficacy of extraembryonic tissue-derived stem cell in improving blood flow within animal models of hindlimb ischemia. [Heart] Abstract Myeloablative, but Not Reduced-Intensity, Conditioning Overcomes the Negative Effect of Flow-Cytometric Evidence of Leukemia in AML Scientists evaluated the effect of flow cytometry status on outcomes of allogeneic hematopoietic cell transplantation for acute myeloid leukemia (AML) after either myeloablative conditioning myeloablative conditioning or reduced-intensity conditioning regimens. The allografts included 130 umbilical cord blood and 73 sibling donors. [Biol Blood Marrow Transplant] Abstract Immunoregulatory Effects on T lymphocytes by Human Mesenchymal Stromal Cells Isolated from Bone Marrow, Amniotic Fluid and Placenta Mesenchymal stromal cells (MSCs) isolated from amniotic fluid and placenta were compared with bone marrow-MSCs. Their immunomodulant properties were studied on total activated T-cells with phytoemoagglutin. [Exp Hematol] Abstract |