Cord Blood News 8.25 June 30, 2016 | |
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TOP STORYResearchers identified microRNA (miRNA)-3662 as a new functional driver contributing to the associated phenotypes. The genome-wide association studies SNPs are strongly associated with higher miR-3662 expression. [Cancer Discov] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Telomeres, the repetitive DNA-protein structures at chromosome ends, influence cellular replicative capacity in that critically short telomeres can induce cell senescence or apoptosis. The authors’ objective was to evaluate the impact of telomere length on duration of post-therapy neutropenia in a pediatric acute myeloid leukemia cohort. [J Clin Oncol] Abstract Based on analysis of 17 paired lymph node (LN) and peripheral blood (PB) samples from chronic lymphocytic leukemia (CLL) patients, researchers identified a panel of miRNAs that are increased in LN CLL cells correlating with an activation phenotype. When evaluated in CLL cells from 38 patients pre- and post-treatment with ibrutinib, a subset of these miRNAs was significantly decreased in response to ibrutinib. [Leukemia] Abstract The authors showed that human umbilical cord-derived mesenchymal stem cells infected by Ad-hTERTp-IL24 followed by LentiR.E1A infection could specifically migrate to HepG2 tumor cells and support adenoviral replication in vitro and in vivo 36 hours after LentiR.E1A infection. [Oncotarget] Full Article Investigators showed that pigs with umbilical cord-derived mesenchymal stromal cells (UC-MSCs) transplantation exhibited significantly greater left ventricular ejection fraction compared with control animals. The systolic thickening fraction in the infarcted left ventricular wall was also improved. Additionally, the administration of UC-MSCs promoted collateral development and myocardial perfusion. [Stem Cells Transl Med] Abstract Extracellular DNA Traps Released by Acute Promyelocytic Leukemia Cells through Autophagy Investigators provide the first evidence that a small percentage of acute promyelocytic leukemia (APL) cells undergo a novel cell death pathway by releasing extracellular DNA traps in untreated patients. Both APL and NB4 cells stimulated with APL serum had nuclear budding of vesicles filled with chromatin that leaked to the extracellular space when nuclear and cell membranes ruptured. [Cell Death Dis] Full Article The present work performed a comparative proteomic-based analysis through mass spectrometry on the secretome of human mesenchymal stem cells derived from bone marrow, adipose tissue, and human umbilical cord perivascular cells. [Stem Cells Dev] Abstract Scientists aimed to determine the effect of mesenchymal stromal cells (MSC) isolated from Wharton’s jelly of umbilical cord on lung cancer stem cells (LCSC) derived from human lung tumors: two adenocarcinomas and two squamous cell carcinomas (SCC). LCSC derived from SCC and adenocarcinomas expressed, to varying extents, the more relevant stem cell markers. [Exp Cell Res] Abstract Cord Blood Chimerism and Relapse after Haplo-Cord Transplantation The contribution of the umbilical cord blood graft to long-term transplant outcome remains unclear. Scientists analyzed 39 recipients of haplo-cord transplants with acute myeloid leukemia and myelodysplastic syndrome, engrafted and in remission at two months. [Leuk Lymphoma] Abstract | |
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REVIEWSAn Overview of Infectious Complications after Allogeneic Hematopoietic Stem Cell Transplantation Infections are the most common and significant cause of mortality and morbidity after allogeneic hematopoietic stem cell transplantation. The presence of neutropenia and mucosal damage are the leading risk factors in the early pre-engraftment phase. [J Infect Chemother] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field.
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INDUSTRY NEWSKiadis Pharma N.V. announces that its lead product, ATIR101â„¢, has been granted an expansion to its existing Orphan Drug Designation by the European Medicines Agency to include treatment in a hematopoietic stem cell transplantation. [Kiadis Pharma N.V.] Press Release GlycoMimetics, Inc. announced dosing of the first patient with newly diagnosed acute myeloid leukemia in the Phase II portion of its ongoing Phase I/II study evaluating its novel E-selectin antagonist, GMI-1271, combined with chemotherapy. [GlycoMimetics, Inc.] Press Release The New York City Chapter of The Leukemia & Lymphoma Society has announced John P. Leonard, MD, of Weill Cornell Medicine and NewYork-Presbyterian as its 2016 Manhattan Light The Night® corporate chair. Light The Night is LLS’s largest annual fundraising event held each fall to find cures and provide access to treatments for blood cancer patients. [The Leukemia & Lymphoma Society] Press Release | |
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POLICY NEWSResearchers Reeling as UK Votes to Leave EU The United Kingdom’s vote to leave the European Union has plunged it into political and economic uncertainty — and left researchers worried over the future of their funding and collaborations, the UK’s participation in major European research programs, and the freedom of movement and employment status of thousands of scientists. [Nature News] Editorial
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EVENTSNEW Danish Stem Cell Society 2016 Visit our events page to see a complete list of events in the cord blood community.
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JOB OPPORTUNITIESNEW PhD Studentship – Various Projects (Vienna Biocenter) NEW Copy Editor – Nature Reviews Molecular Biology (Springer Nature) Technical Sales Representative (STEMCELL Technologies Inc.) Postdoctoral Fellow – Characterizing and Targeting Cancer Stem Cells (City of Hope) Postdoctoral Fellow – Tumor Microenvironment and Cancer Stem Cells (Duke University) Research Assistants and Associates – Leukemia and Stem Cell Biology (King’s College London) Postdoctoral Research Associate – Myeloid Leukemia (Upstate Medical University) Postdoctoral Research Associate – TAM-Family Kinases in Leukemogenesis (Emory University) Postdoctoral Fellow – Hematology/Oncology (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Cord Blood News Volume 8.25 | Jun 30 2016