Cord Blood News 8.36 September 15, 2016 | |
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TOP STORYRole of IGF1R+ MSCs in Modulating Neuroplasticity via CXCR4 Cross-Interaction An insulin-like growth factor 1 receptor (IGF1R)–expressing sub-population in human dental pulp MSCs (hDSCs), displayed multipotent properties. IGF1R expression could be maintained in hDSCs when they were cultured in 2% human cord blood serum in contrast to that in 10% fetal calf serum. [Sci Rep] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators aimed to assess the safety and efficacy of articular cartilage regeneration by a novel medicinal product composed of allogeneic human umbilical cord blood-derived mesenchymal stem cells. [Stem Cells Transl Med] Abstract To describe the hematopoietic stem cell transplantation activities for children in the Eastern Mediterranean (EM) region, data on transplants performed for children less than 18 years of age between 1984 and 2011 in eight EM countries were collected. A total of 5187 transplants were performed, of which 4513 were allogeneic and 674 were autologous. [Bone Marrow Transplant] Abstract Comparison of Human Neonatal and Adult Blood Leukocyte Subset Composition Phenotypes Researchers confirmed higher frequencies of monocytes and regulatory T cells, similar frequencies of neutrophils, and lower frequencies of CD8 T cells, NKT cells, B1 B cells and gamma-delta T cells in neonatal umbilical cord blood. [PLoS One] Full Article Loss of ASXL1 Triggers an Apoptotic Response in Human Hematopoietic Stem and Progenitor Cells To determine the role of ASXL1 loss in normal hematopoietic stem and progenitor cells, cord blood CD34+ cells were transduced with independent shRNAi lentiviral vectors against ASXL1 and cultured under myeloid and erythroid permissive conditions. [Exp Hematol] Abstract Scientists characterized the early neural markers of human umbilical cord mesenchymal stem cells (hUC-MSCs)-derived cells under different conditions. They found that neither the elimination of signals for alternative fate nor N2 supplement was sufficient to differentiate hUC-MSCs into neural precursor cells, but the GSK3 inhibitor SB216763 could promote an efficient neural commitment of hUC-MSCs. [Hum Cell] Abstract Researchers evaluated and compared the ability to inhibit allo-activated lymphocytes proliferation by mesenchymal stem cells derived from different sources: amniotic membrane, umbilical cord and adipose tissue. [Gynecol Obstet Invest] Abstract The authors identified the potential benefits of decitabine as a prior therapy before salvaged unrelated unrelated cord blood transplantation for refractory or relapsed childhood acute leukemia. [Pediatr Transplant] Abstract | |
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REVIEWSThe authors discuss recent clinical trials for pediatric diseases studying mesenchymal stem cells obtained from bone marrow, umbilical cord and umbilical cord blood, placenta, amniotic fluid, and adipose tissue. [Stem Cells Transl Med] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSFDA Approves the Cleveland Cord Blood Center’s CLEVECORD™ for Stem Cell Transplants The U.S. Food and Drug Administration (FDA) has issued a biologics license to the Cleveland Cord Blood Center for CLEVECORD™, a stem cell product derived from umbilical cord blood. [Cleveland Cord Blood Center] Press Release Gamida Cell announced the appointment of Julian Adams, Ph.D., and Kenneth I. Moch to its Board of Directors. [Gamida Cell] Press Release | |
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POLICY NEWSEurope Proposes Copyright Reform to Help Scientists Mine Research Papers The European Commission has announced long-awaited plans to make it easier for researchers to harvest facts and data from research papers — by freeing the computer-aided activity from the shackles of copyright law. [Nature News] Editorial Illusory Fears Must Not Stifle Chimera Research After more than a decade of controversy, the United States is nudging towards approving research on human–animal embryos. The National Institutes of Health closed a month-long public consultation on ‘chimera research’, and is widely expected to lift a moratorium that forbids federal funding for such work. [Nature News] Editorial Report Urges Trump, Clinton to Make Room for Science in the White House A new report on how the next U.S. president should manage the nation’s science portfolio comes with an invisible sticker on its cover: Open and read immediately if Donald Trump is elected. [Science Insider] Editorial
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EVENTSNEW Stem Cells in Drug Discovery NEW Cord Blood World Europe 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate Position – Blood Cancer and Epigenetic Research (University of Miami) Chair – Medical Biology (Masaryk University) PhD Position – Tumor Microenvironment in Leukemia (Georg-Speyer-Haus) Senior Research Scientist – Cancer Research (Anthony Nolan Trust) Research Fellow – Cancer Biology (University of Michigan) Postdoctoral Position – Tumor Immunology (Roswell Park Cancer Institute) Postdoctoral Fellow – Hematopoietic Stem Cells (University of Pennsylvania) Assistant Member Faculty – PlatinumImmunotherapy (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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