Cord Blood News 9.44 November 9, 2017 | |
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TOP STORYThe authors describe the in vitro maturation and selection of mouse and human T cells on antigen-expressing feeder cells to develop higher-affinity T cell receptors. The approach takes advantage of natural Tcrb gene rearrangement to generate diversity in the length and composition of CDR3β. [Nat Biotechnol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists used HepG2 cells, a human hepatoma cell line, and a MSC-HepG2 transwell culturing system to investigate the anti-inflammatory mechanism of human umbilical cord-derived MSCs under palmitic acid and lipopolysaccharide-induced insulin resistance in vitro. [Stem Cell Res Ther] Full Article Researchers characterized the differentiation of Wharton’s jelly-MSCs into endometrial epithelial cell-like and endometrial stromal cell-like cells and assessed the effect of 17β-estradiol and 8-Br-cAMP on the differentiation system. [Stem Cell Res Ther] Full Article The authors investigated whether amniotic fluid-derived stem cells equipped with glial-derived neurotrophic factor (GDNF-AFSCs) had capabilities of attenuating mouse renal tubular epithelial cells apoptosis and evaluated its potential mechanisms. They revealed that expression of growth factors was increased and oxidative stress was dramatically counteracted in GDNF-AFSCs-treated group. [Cell Prolif] Abstract Scientists explored the biological properties of nucleus pulposus (NP) stem/progenitor cells isolated from degenerated intervertebral disc regarding immunotype, proliferative capacity, multi-lineage differentiation abilities, and the expression of NP specific cell surface markers compared to human umbilical cord MSCs. [Exp Cell Res] Abstract Since hematopoietic stem cells (HSCs) from fetal liver (FL), cord blood (CB), and bone marrow (BM) are produced at various stages of human development, investigators tested whether mice transplanted with these three HSCs differ in their immune responses. They found that compared with CB HSCs or FL HSCs, adult BM HSCs reconstitute the immune system poorly. [Stem Cells Dev] Abstract Resveratrol Promotes hUC-MSCs Engraftment and Neural Repair in a Mouse Model of Alzheimer’s Disease Researchers explored whether resveratrol regulates the fate of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) and whether hUC-MSCs combined with resveratrol would be efficacious in the treatment of neurodegeneration in a mouse model of Alzheimer’s disease through silent information regulator 2, homolog 1 signaling. [Behav Brain Res] Abstract Investigators compared the treatment effect of human umbilical cord blood-derived mesenchymal stromal cells (hUCB-MSCs) with that of fibroblasts on the diabetic wound healing in vitro. The hUCB-MSC-treated group showed higher cell proliferation, collagen synthesis and glycosaminoglycan level than a fibroblast-treated group. [Int Wound J] Abstract Researchers demonstrated that the transcription profile of naive CD4+ T cells from cord blood and that of lymphocytes reconstituting after cord blood transplantation is similar to the transcription profile of fetal CD4+ T cells. This profile was distinct to that of naive CD4+ T cells from peripheral blood and that of lymphocytes reconstituting after T-replete bone marrow transplantation. [Blood Adv] Full Article | Graphical Abstract | |
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REVIEWSAnticancer Cellular Immunotherapies Derived from Umbilical Cord Blood The authors summarize data on the transfer of naturally occurring or genetically modified umbilical cord blood cells to treat cancer. The focus within is on the phenotypic and functional differences compared to other sources, the alloreactive and anticancer properties, and manufacturing of these products. [Expert Opin Biol Ther] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWS$6 Million Supports Leukemia Research John F. DiPersio, MD, PhD, of Washington University School of Medicine in St. Louis, has received a $6 million outstanding investigator award from the National Cancer Institute of the National Institutes of Health to support research aimed at improving therapies for leukemia. [Washington University School of Medicine in St. Louis] Press Release Jazz Pharmaceuticals plc announced the submission of a Marketing Authorization Application to the European Medicines Agency’s Committee for Medicinal Products for Human Use for Vyxeos™ powder for concentrate for infusion to treat adults with high-risk acute myeloid leukemia (AML) defined as therapy-related AML or AML with myelodysplasia-related changes. [Jazz Pharmaceuticals plc] Press Release | |
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POLICY NEWSUK Government Appoints Next Chief Scientific Adviser Patrick Vallance, president of research and development at the pharmaceutical giant GlaxoSmithKline, has been appointed as chief scientific adviser, the UK government announced. [Nature News] Editorial Indian Scientists Urged to Speak Out about Pseudoscience A leading Indian science-advocacy group is urging the country’s researchers to speak out against pseudoscience, which it fears has gained a foothold in the past few years, partly through support from some agencies of the Indian government. [Nature News] Editorial Court Demands that Search Engines and Internet Service Providers Block Sci-Hub The American Chemical Society (ACS) has won a lawsuit against Sci-Hub, a website providing illicit free access to millions of paywalled scientific papers. ACS had alleged copyright infringement, trademark counterfeiting and trademark infringement; a district court in Virginia ruled that Sci-Hub should pay the ACS $4.8 million in damages after Sci-Hub representatives failed to attend court. [ScienceInsider] Editorial
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EVENTSNEW 4th Annual Perinatal Stem Cell Society Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Scientist – Hematopoietic Stem Cells (Karlsruhe Institute of Technology) Faculty Positions – Hematological Malignancies (University of Alabama at Birmingham) Postdoctoral Fellow – Hematology (University of Tennessee Health Science Center) Postdoctoral Position – Mesenchymal Stem Cells (University of Southern California) Postdoctoral Fellowship – Development & Epigenetics (Centre National de la Recherche Scientifique) Postdoctoral Fellow – Hematopoietic Stem Cells (Memorial Sloan Kettering Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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