Cord Blood News 10.08 March 1, 2018 | |
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TOP STORYInvestigators compared the therapeutic potential of pluripotent stem cell-derived MSCs (ES-MSCs from embryonic stem cells) to fetal MSCs (AF-MSCs from the amniotic fluid), demonstrating that ES-MSCs have a superior neuroprotective potential over AF-MSCs in the mouse brain following hypoxia-ischemia. [Stem Cells Transl Med] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists showed that the inclusion of cellular components within the 3D-extracellular-matrix (ECM) scaffolds was necessary for maintenance of hematopoietic stem/progenitor cell (HSPC) viability in culture, and that irrespective of the microenvironment used, the 3D-ECM structures led to the maintenance of a more primitive subpopulation of HSPC, as determined by flow cytometry and colony forming assays. [Stem Cells Transl Med] Full Article A Comparison of Bone Marrow and Cord Blood Mesenchymal Stem Cells for Cartilage Self-Assembly While both bone marrow-derived MSCs and cord blood (CB) MSCs were able to form neocartilage, CB-MSCs resulted in tissue more closely resembling native equine articular cartilage as determined by a quantitative functionality index. [Tissue Eng Part A] Abstract | Full Article Investigators compared the ability of congenic and allogeneic mouse amniotic fluid stem cells (AFSC) to engraft the hematopoietic system of time-mated C57BL/6J mice. In utero (IUT) transplantation with congenic cells resulted in 100% of donor animals having chimerism of around 8% and successful hematopoietic long-term engraftment in immune-competent mice when compared to IUT with allogeneic cells. [Stem Cells Dev] Abstract | Full Article Human umbilical cord mesenchymal stem cells (HUMSCs) were isolated, differentiated and characterized in vitro. Both HUMSCs and smooth muscle cells differentiated from HUMSCs were used to fabricate tissue-engineered fascia equivalents. [Cell Tissue Res] Full Article Human Umbilical Cord Mesenchymal Stem Cells Inhibit Proliferation of Hepatic Stellate Cells In Vitro Scientists explored the mechanism of action of human umbilical cord mesenchymal stem cells (HUMSCs) on the proliferation of hepatic stellate cells (HSCs) in vitro. The upper and lower double-cell co-culture system was established between hUC‑MSCs and HSCs in the experimental group. HSCs were cultured alone as a negative control group. [Int J Mol Med] Full Article | |
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REVIEWSEnhancer DNA Methylation in Acute Myeloid Leukemia and Myelodysplastic Syndromes The authors assembled recent data regarding DNA methylation and enhancers’ activity in normal and mainly myeloid malignancies. [Cell Mol Life Sci] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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SCIENCE NEWSMagenta Therapeutics announced the presentation of pre-clinical and clinical data from its expansion, conditioning and mobilization programs. [Press release from Magenta Therapeutics discussing research presented at the American Society of Bone Marrow Transplant (ASBMT) Annual Bone Marrow Transplant Tandem Meeting, Salt Lake City] Press Release | |
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INDUSTRY NEWSWideCells Group PLC has taken a “significant step” towards becoming an end-to-end stem cell service company, according to chief executive João Andrade. The official approval allows the group, under its brand name BabyCells, to offer umbilical cord blood and tissue storage services to clients in the UK and Europe. [WideCells Group PLC (Proactive Investors)] Press Release Jazz Pharmaceuticals plc announced that the first patient has been enrolled in a Phase II clinical trial evaluating the efficacy and safety of defibrotide for the prevention of acute graft-versus-host-disease in adult and pediatric patients after allogeneic hematopoietic stem cell transplant. [Jazz Pharmaceuticals plc] Press Release | |
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POLICY NEWSEU Research Chief’s Next Act: Changing the Future of Academic Publishing Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business] Editorial Canadian Science Wins Billions in New Budget Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News] Editorial Merkel Makes a Surprise Pick for German Research Minister German Chancellor Angela Merkel isn’t known for her political surprises. But she managed a big one when she tapped Anja Karliczek, a 46-year-old lawmaker little known outside of party circles, as Germany’s next minister for education and research. [ScienceInsider] Editorial
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EVENTSNEW LabRoots: 2nd Annual Cell Biology Virtual Event Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow & Scientist – Acute Myeloid Leukemia (Institute of Hematology) Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital) Postdoctoral Fellowship – Leukemia (Lund University) Postdoctoral Research Associate – Hematopoiesis (University of North Dakota) Postdoctoral Scholar – Leukemia (University of Southern California) Postdoctoral Research Fellow – Fanconi Anemia (Cincinnati Children’s Hospital Medical Center) Scientific Manager – Cell Engineering Lab (Genentech, Inc.) Research Fellow – Pediatric Cancer and Zebrafish Models (Massachusetts General Hospital) Postdoctoral Scientists and Research Technologists – Hematopoiesis and Leukemogenesis (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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