Cord Blood News 10.12 March 29, 2018 | |
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TOP STORYA Humanized Mouse Model Generated Using Surplus Neonatal Tissue Researchers describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells. [Stem Cell Reports] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists investigated the role of exosomes derived from maternal (ME) and umbilical (UE) cord blood in the regulation of angiogenesis. They report that both MEs and UEs significantly enhance HUVEC proliferation, migration, and tube formation. [FASEB J] Abstract | Full Article CRISPR/Cas9-Based Cellular Engineering for Targeted Gene Overexpression Investigators employed the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system to insert powerful regulatory elements upstream of an endogenous gene. They achieved robust activation of the COL7A1 gene in primary human umbilical cord blood CD34+ hematopoietic stem cells and peripheral blood T-cells. [Int J Mol Sci] Full Article Researchers investigated the role of Wharton’s jelly mesenchymal stromal cells (WJ-MSCs) in supporting ex vivo umbilical cord blood-hematopoietic stem/progenitor cells (UCB-HSPCs) expansion either when cultured in direct contact with WJ-MSCs or separated by a transwell system or in the presence of WJ-MSC-conditioned medium. [Cell Transplant] Abstract Investigators found that human cord blood serum significantly promotes soluble amyloid procurer protein (APP) production compared with adult blood serum and aged blood serum in Chinese hamster ovary cells stably expressing wild-type human APP. [Cell Transplant] Abstract Scientists compared the biological characteristic of stem cells isolated from different human tissues (adipose tissue and amniotic fluid) with respect to myogenic capacity and skeletal and smooth muscle differentiation under the same conditions. [Med Sci Monit] Abstract | |
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REVIEWSCurrent Approaches in Biomaterial-Based Hematopoietic Stem Cell Niches While there is a growing demand for autologous and allogeneic hematopoietic stem cell (HSC) transplantation owing to the increasing incidence of hereditary and hematologic diseases, the low population of HSCs in cord-blood and bone marrow hinders their medical applicability. Several cytokine and growth factor-based methods have been developed to expand the HSCs in vitro; however, the expansion rate is low, or the expanded cells fail to survive upon engraftment. [Acta Biomater] Abstract Visit our reviews page to see a complete list of reviews in the cord blood research field. | |
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INDUSTRY NEWSMultiple Myeloma Research Foundation announced that, as part of its $15M Immunotherapy Initiative, it has awarded $7M in funding to three ground-breaking research programs led by renowned myeloma researchers. [Multiple Myeloma Research Foundation] Press Release FDA Grants Orphan Drug Designation to Cynata’s Lead Cymerus™ MSC Product, CYP-001 Cynata Therapeutics Limited announced that the FDA has granted Cynata Orphan Drug Designation for CYP-001 for the treatment of acute graft versus host disease. [GlobeNewswire] Press Release | |
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POLICY NEWSIndia Taps Biologist as New Science Adviser India has a new science adviser. Prime Minister Narendra Modi’s government tapped Krishnaswamy VijayRaghavan, a molecular biologist and head of India’s Department of Biotechnology, to fill the post. [ScienceInsider] Editorial Cambridge Analytica Controversy Must Spur Researchers to Update Data Ethics Revelations keep emerging in the Cambridge Analytica personal-data scandal, which has captured global public attention. But when the dust settles, researchers harvesting data online will face greater scrutiny. And so they should. [Nature News] Editorial Duke’s Mishandling of Misconduct Prompts New U.S. Government Grant Oversight The U.S. National Institutes of Health imposed unusual new requirements on researchers based at Duke University in Durham, North Carolina, who receive federal funds. The changes are a response to concerns over how the institution handled recent cases involving research misconduct and grant management. [ScienceInsider] Editorial Massive Cyberhack by Iran Allegedly Stole Research from 320 Universities, Governments, and Companies Nine Iranians working on behalf of the Islamic Revolutionary Guard Corps hacked the computers of 7998 professors at 320 universities around the world over the past five years, an indictment filed by a federal grand jury alleges. [ScienceInsider] Editorial
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EVENTSNEW Cord Blood Connect Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technician – Acute Myeloid Leukemia (European Molecular Biology Laboratory) NEW Pathology Faculty Tenure Track – Leukemia and Hematopoiesis (University of Virginia) Postdoctoral Scholar – Hematology (Huntsman Cancer Institute) Postdoctoral Scholar – Clonal Hematopoiesis (Stanford University) Postdoctoral Fellow – Leukemia (Washington University) Postdoctoral Fellowship – Cell and Molecular Biology (Canadian Nuclear Laboratories) Postdoctoral Positions – Molecular Biology (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow & Scientist – Acute Myeloid Leukemia (Institute of Hematology) Postdoctoral Fellowship – Functional Genomics of Human Hematopoiesis (Boston Children’s Hospital) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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